Phase
Condition
Osteoarthritis
Treatment
Placebo
Allocetra
Clinical Study ID
Ages 45-80 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Age 45 - 80 years.
Chronic osteoarthritis of index knee with knee-related joint pain
Radiographic evidence of knee osteoarthritis of K-L Grade 2 or 3 in the index knee.
Knee pain assessed daily over a period of 7 days during the screening period andfollowing wash-out of pain medications
Patients with chronic knee pain for at least 3 months who have failed to respondadequately to conventional therapy.
Willing to abstain from other intra-articular treatments and adhere to the protocolrestrictions for concomitant medications and therapies during the study.
Women of childbearing potential and all men must agree to use 2 methods of anadequate contraception prior to study entry and for the duration of studyparticipation through 4 weeks following IP administration.
Exclusion
Exclusion Criteria:
Wheelchair bound.
Immunosuppressive therapy
Any known current or prior tumor of the index knee.
Any known history or current intra-articular or osseous infection of the index knee.
Any evidence of clinically significant active infection
Any known history of inflammatory arthropathy or crystal-deposition arthropathy
Any known severe systemic cartilage and/or bone disorder, such as, but not limitedto, chondrodysplasia, osteogenesis imperfecta.
Body Mass Index (BMI) >40.
Any major surgical cartilage treatment within 6 months
Any ligamentous repair or malalignment correction in the index knee within 6 months
Major injury to the index knee, such as torn ligament or severe sprain within 6months
Clinically relevant knee instability of the index knee
Severe hip osteoarthritis ipsilateral to the index knee.
Clinically significant widespread pain syndromes, e.g., fibromyalgia, long COVIDsyndrome.
Known coagulopathy, or use of anticoagulation medication or antiaggregantmedication;.
certain tumors, severe cardiac, respiratory or hematologic diseases as defined inthe protocol
Study Design
Study Description
Connect with a study center
Sanos Clinic Nordjylland
Gandrup, 9362
DenmarkSite Not Available
Sanos Clinic Herlev
Herlev, 2730
DenmarkActive - Recruiting
Sanos Clinic Syddanmark
Vejle, 7100
DenmarkSite Not Available
Haemek Medical Center
Afula,
IsraelSite Not Available
Barzilai Medical Center
Ashkelon, 7830604
IsraelActive - Recruiting
Rambam Medical Center
Haifa, 7651211
IsraelActive - Recruiting
Beilinson Medical Center
Petach Tikva, 4941492
IsraelSite Not Available
Hasharon Medical Center
Petach Tikva, 4937211
IsraelSite Not Available
Sheba Medical Center
Ramat Gan, 5266202
IsraelActive - Recruiting
Kaplan Medical Center
Reẖovot, 7661041
IsraelActive - Recruiting
Ichilov - Tel Aviv Sourasky Medical Center
Tel Aviv, 6423906
IsraelActive - Recruiting
Not the study for you?
Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.