The Feasibility, Safety and Tolerability of VR-based Audiovisual Stimulation

Inclusion Criteria Mild AD/ MCI due to AD Participants:

• Age between 50 - 90 years old.

• A clinical diagnosis of Mild Cognitive Impairment due to Alzheimer's disease (confirmed by PET scan or CSF biomarkers) or Mild Alzheimer's disease

• MoCA score of 18-25.

• Willingness to sign informed consent document (if deemed to not have the capacity to sign the informed consent, a legally authorized representative will be asked to provide surrogate consent).

• Sufficient visual and hearing ability.

• Formal education of 8 or more years.

• Native English speakers or demonstrated fluency in English (participant; and LAR as needed)

Inclusion Criteria Cognitively Healthy Participants:

• Age between 50 - 90 years old.

• A MoCA score above or equal to 26.

• Willingness to sign informed consent document.

• Sufficient visual and hearing ability.

• Formal education of 8 or more years.

• Native English speakers or demonstrated fluency in English (participant)

Exclusion Criteria Mild AD/ MCI due to AD Participants:

• Previous exposure to monoclonal antibody medication (e.g., Lecanemab, Aducanumab).

• Active treatment with Memantine within the past 30 days.

• Initiation of acetylcholinesterase inhibitors within the past 30 days.

• A history of seizure or epilepsy including family history of seizure or epilepsy.

• A history of stroke.

• A diagnosis of migraine headache.

• History of alcohol use disorder within the past 2 years (DSM-V criteria).

• Current or past history of any neurological disorder other than dementia.

• Use of hearing aid device(s).

• Any known blood pathogens or disorders.

• Has any clinically significant medical disorder, condition, disease or clinically significant finding at screening that precludes participant's participation in study activities.

• Pregnancy (Verbal confirmation).

• Geriatric Depression Scale (GDS) >8

Exclusion Criteria Cognitively Healthy Participants:

• Active treatment with Memantine within the past 30 days.

• Initiation of treatment with acetylcholinesterase inhibitors (e.g., donepezil, rivastigmine and galantamine) within the past 30 days.

• A history of seizure or epilepsy including family history of seizure or epilepsy.

• A history of stroke.

• A diagnosis of migraine headache.

• History of alcohol use disorder within the past 2 years (DSM-V criteria).

• Use of hearing aid device(s).

• Any known blood pathogens or disorders.

• A diagnosis of Alzheimer's disease and related dementias.

• Has any clinically significant medical disorder, condition, disease or clinically significant finding at screening that precludes participant's participation in study activities.

• Pregnancy (Verbal confirmation)

• Geriatric Depression Scale (GDS) >8