Prospective and Multicenter Italian Registry of Locally Advanced-Metastatic Urothelial Carcinoma

Inclusion Criteria:

• Cytological and/or histological diagnosis of urothelial carcinoma or at least with oneurothelial component originating from the genitourinary tract.
• Radiological diagnosis of metastatic or locally advanced disease inoperable
• Primary bladder, ureter, renal pelvis and of the urethra are included
• No previous chemotherapy for advanced urothelial carcinoma or metastatic disease
• Age over 18 years old
• Ability to understand and sign the informed consent
• Patients for whom the clinician has opted for a therapeutic path not including activesystemic treatments (iter palliative or observation) with certain diagnosis ofmetastatic disease
• Patients with lymph node extension of the disease who are not candidates toneoadjuvant treatment
• Any ECOG PS and therapeutic management is permitted.
• Previous surgeries and antineoplastic treatments are permitted as long as not carriedout for metastatic disease (adjuvant and/or neoadjuvant)

Exclusion Criteria:

• Patients who have received previous systemic treatment for metastatic disease
• Patients with histological and/or cytological diagnosis without urothelial component
• Patients with muscle-infiltrating disease without evidence of metastatic disease
• Patients with non-muscle infiltrating disease without evidence of metastatic disease