Fluid Administration and Fluid Accumulation in the Intensive Care Unit

Last updated: February 5, 2025
Sponsor: Nordsjaellands Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT06258616
FLUID-ICU
  • Ages > 18
  • All Genders

Study Summary

The goal of this international inception cohort study is to describe fluid administration during admittance to the intensive care unit (ICU), and provide contemporary epidemiological data on fluid accumulation, risk factors, management and outcome in critically ill adult patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Acute admission to the ICU during the 14-day inception period.

  • Adults (≥ 18 years).

Exclusion

Exclusion Criteria:

  • Patients previously included in the FLUID-ICU study.

  • Patients with major burns (≥ 10% of body surface)

Study Design

Total Participants: 1000
Study Start date:
April 01, 2024
Estimated Completion Date:
September 30, 2025

Study Description

Background: Fluid accumulation is associated with adverse outcome in ICU patients, however, assessment of fluid status is often difficult and no established definition and consistent detection method exists. Former research has primarily focused on the use of resuscitation fluid, but a substantial amount of fluid is administered throughout the entire ICU stay and this fluid may be a clinically relevant source of fluid accumulation.

Objectives: To describe fluid administration practices during the entire ICU stay, and provide contemporary epidemiological data on fluid accumulation, fluid removal, risk factors and association with patient outcomes from a worldwide perspective.

Study design: International inception cohort study. Patients will be included during a 14-day inception period to be chosen by each participating site.

Population: Critically ill adult patients (≥ 18 years) with acute admission to the ICU.

Intervention: None. Only routinely available data will be collected.

Study duration: Patients are followed daily until ICU discharge or death for a maximum of 28 days. Follow-up is performed 90 days after ICU admission.

Connect with a study center

  • Department of Intensive Care, Sygehus Sønderjylland Aabenraa

    Aabenraa,
    Denmark

    Site Not Available

  • Departmen of Intensive Care

    Aalborg, 9000
    Denmark

    Site Not Available

  • Department of Intensive Care, University hospital Aarhus

    Aarhus,
    Denmark

    Site Not Available

  • Department of Intensive Care, Bispebjerg

    Copenhagen, 7100
    Denmark

    Active - Recruiting

  • Department of Intensive Care, Rigshospitalet 4131

    Copenhagen, 2100
    Denmark

    Active - Recruiting

  • Department of Intensive Care, Herlev Hospital

    Herlev, 2730
    Denmark

    Completed

  • Department of Intensive Care, Regionshospital Gødstrup

    Herning, 7400
    Denmark

    Site Not Available

  • Deparment of Intensive care, Nordsjællands hospital

    Hillerød, 3400
    Denmark

    Completed

  • Department of Intensive Care, Zealand University hospital

    Køge, 4600
    Denmark

    Completed

  • Department of Intensive Care, Regionshospitalet Randers

    Randers, 8930
    Denmark

    Site Not Available

  • Department of Intensive Care, University Hospital Zealand, Roskilde

    Roskilde,
    Denmark

    Completed

  • Department of Intensive Care, Tampere University Hospital

    Tampere, 33520
    Finland

    Site Not Available

  • Department of Intensive Care, Landspitali National University Hospital of Iceland

    Reykjavík,
    Iceland

    Completed

  • Department of Anaesthesiology, Critical Care and Pain Tata Memorial Hospital, Mumbai.

    Mumbai,
    India

    Site Not Available

  • Department of Anaesthesia and Critical Care Vilnuis University Hospital Santariskiu Cinics, Vilnuis

    Vilnius,
    Lithuania

    Site Not Available

  • Department of Intensive Care Wellington Hospital (CCDHB), Newton, Wellington

    Wellington,
    New Zealand

    Completed

  • Department of Intensive Care, Stavanger University Hospital

    Stavanger, 4068
    Norway

    Site Not Available

  • Hospital Clinic of Barcelona

    Barcelona,
    Spain

    Active - Recruiting

  • Helsingborg Hospital

    Helsingborg,
    Sweden

    Site Not Available

  • Department of Intensive Care, Inselspital

    Bern,
    Switzerland

    Completed

  • General Adult Intensive Care Unit, Critical Care Directorate University Hospital of Wales, Cardiff

    Cardiff,
    United Kingdom

    Site Not Available

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