A Study to Assess and Compare Safety and Tolerability of 3 Months Treatment With Salbutamol Administered Via MDI Containing Propellant HFA-152a or HFA-134a in Participants ≥ 18 Years of Age With Asthma

Inclusion Criteria:

1. Participant of ≥18 years of age at the time of signing the informed consent orwritten informed consent is obtained from each study participant's legal guardian.

2. Asthma for ≥ 6 months, defined as:

• Documented history of asthma, as defined by Global Initiative for Asthma (GINA) (GINA, 2023]

• Receiving one of the following asthma treatments, at a stable dose (applicableto daily Inhaled corticosteroid (ICS), ICS/Long-acting bronchodilator (LABA),and ICS/LABA/Long-acting muscarinic antagonist [LAMA]), for at least 12 weeksprior to the screening visit, with treatment that is anticipated to remainstable for the duration of the study:

• Short-Acting Beta-2-Adrenoreceptor Agonists (SABA) used as needed forasthma symptoms

• Daily maintenance low to medium dose Inhaled corticosteroid (ICS) (low tomedium dose ICS defined as 100-500 μg/day fluticasone propionate orequivalent as defined in the 2023 GINA guidelines [GINA, 2023], plusShort-Acting Beta-2-Adrenoreceptor Agonists (SABA), which is anticipatedto remain stable for the duration of the study.

• Daily maintenance low to medium dose ICS/ Long-acting bronchodilator (LABA) (low to medium dose ICS defined as 100-500 μg/day fluticasonepropionate or equivalent as defined in the GINA guidelines [GINA, 2023]plus SABA, which is anticipated to remain stable for the duration of thestudy.

• Daily maintenance ICS/LABA/LAMA (low to medium dose ICS defined as 100-500 µg/day fluticasone propionate or equivalent as defined in the GINAguidelines [GINA, 2023] plus SABA, which is anticipated to remain stablefor the duration of the study.

• Participants who utilize combination budesonide/formoterol as relievertherapy, whether or not this is in addition to a SABA - are not eligiblefor screening.

• Participants who utilize ICS/SABA combination therapy as reliever therapy,in addition to low to medium dose ICS or ICS/LABA as maintenance, are onlyeligible if they agree to discontinue their ICS/SABA inhaler for theduration of the study (screening through follow-up).

3. Severity of disease assessed by the investigator by baseline pre-bronchodilatorForced expiratory volume in 1 second (FEV1)

4. Asthma Control Status

• Asthma Control Questionnaire (ACQ) 6 score <1.5 at screening

• Asthma that has remained stable with no severe exacerbations in the last 6months. Severe exacerbation defined as:

• Deterioration of asthma-requiring the use of systemic corticosteroids (tablets, suspension or injection), for at least 3 days, OR

• An inpatient hospitalization or Emergency Department (ED) visit because ofasthma, requiring systemic corticosteroids.

5. Evidence of reversibility of disease: Airway reversibility is defined as ≥12 percent (%) and ≥200 milliliter (mL) increase in FEV1 within 20 to 60 minutes following upto 4 inhalations of albuterol/salbutamol aerosol.

6. Participants on as-needed SABA only, or daily maintenance ICS (plus as needed SABA):

• With a documented history of reversibility (as defined above) within 2 yearswill meet this inclusion criterion. Pre- and post-bronchodilator measurementswill still be collected at screening to characterize the degree ofreversibility.

• Who do not have a documented history of reversibility within the past 2 yearswill need to demonstrate reversibility during the screening period.

• SABA should be withheld for ≥6 hours

• Participants on daily maintenance ICS/LABA or ICS/LABA/LAMA:

7. Participants on daily maintenance ICS/LABA or ICS/LABA/LAMA:

• Do not need to demonstrate reversibility in accordance with the abovedefinition during the screening period. A reversibility maneuver will beperformed to characterize the degree of post-bronchodilator change.
• SABA should be withheld for ≥6 hours
• LABA- and LAMA-containing medications should be withheld for >=24 hoursfor the characterization of post-bronchodilator change.

Participants should be able to withhold SABA for ≥6 hours and LABA-/ LAMA containing medications for ≥24 hours for the purposes of performing screening spirometry.

Exclusion Criteria:

1. A history of life-threatening asthma or asthma that is unstable in the opinion ofthe investigator.

2. Other significant pulmonary diseases to include (but not limited to): pneumothorax,pulmonary fibrotic disease, bronchopulmonary dysplasia, chronic bronchitis,emphysema, chronic obstructive pulmonary disease, tuberculosis or other respiratoryabnormalities other than asthma.

3. Respiratory Infection: Culture-documented or suspected bacterial or viral infectionof the upper or lower respiratory tract, sinus or middle ear that is not resolvedwithin 4 weeks of screening that led to a change in asthma management, OR in theopinion of the Investigator, is expected to affect the participant's asthma status,OR the participant's ability to participate in the study.

4. Asthma Exacerbation: Any severe asthma exacerbation within 6 months prior toscreening.

5. Current or chronic history of liver disease or known hepatic or biliaryabnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones)Biologic/immunosuppressive therapies used for the treatment of respiratory diseasesduring the 6 months, or 5 half-lives-whichever is longer-prior to start of thestudy.