Phase
Condition
Neoplasms
Gliomas
Astrocytoma
Treatment
Awake mapping under local anesthesia
Asleep mapping under general anesthesia
Resection under general anesthesia without mapping
Clinical Study ID
Ages < 90 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
- Age ≥18 years and ≤90 years
- Tumor recurrence according to the RANO criteria of a previously diagnosed glioblastomabased on the WHO 2021 classification for glioma
- Tumors situated in or near eloquent areas; motor cortex, sensory cortex, subcorticalpyramidal tract, speech areas or visual areas as indicated on MRI (Sawaya Grading IIand II)19
- The tumor is suitable for resection (according to neurosurgeon)
- Written informed consent
Exclusion
Exclusion Criteria:
- Tumors of the cerebellum, brainstem, or midline
- Multifocal contrast-enhancing lesions
- Medical reasons precluding MRI (e.g., pacemaker)
- Inability to give written informed consent
- Secondary high-grade glioma due to malignant transformation from low-grade glioma
- Clinical data unavailable for the newly diagnosed setting
Study Design
Study Description
Connect with a study center
University Hospital Leuven
Leuven,
BelgiumActive - Recruiting
Universitätsklinikum Heidelberg
Heidelberg,
GermanyActive - Recruiting
Technical University Munich
Munich,
GermanySite Not Available
Erasmus Medical Center
Rotterdam, Zuid-Holland 3015 GD
NetherlandsActive - Recruiting
Haaglanden Medical Center
The Hague,
NetherlandsActive - Recruiting
Inselspital Universitätsspital Bern
Bern,
SwitzerlandSite Not Available
University of California, San Francisco
San Francisco, California 94143
United StatesActive - Recruiting
Massachusetts General Hospital
Boston, Massachusetts 02114
United StatesActive - Recruiting
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