Protein Molecular Characteristics and Prognosis of Cervical Neuroendocrine Tumors

Last updated: September 12, 2024
Sponsor: Fujian Maternity and Child Health Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Pelvic Cancer

Abdominal Cancer

Neuroendocrine Carcinoma

Treatment

N/A

Clinical Study ID

NCT06276309
NECC2401
  • Female

Study Summary

The clinical diagnosis and treatment data of 300 cases of cervical neuroendocrine tumors were collected, including age, preoperative biopsy pathology results, postoperative histopathological results, TCT results, and colposcopy biopsy pathology results. At the same time, paraffin tissue specimens (remaining specimens after pathological diagnosis) from 100 cases of cervical neuroendocrine tumors from multiple centers across the country were collected to establish a cervical neuroendocrine tumor data follow-up database. Protein concentration and omics analysis were performed on the data results, to evaluate the molecular characteristics and prognosis of cervical neuroendocrine tumor proteins, and to preliminarily explore its clinical application value.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Patients diagnosed with cervical neuroendocrine carcinoma by histopathology

  2. Clinical data were complete

Exclusion

Exclusion Criteria:

  1. Patients who are not being treated in our hospital

  2. Patients with lack of follow-up data, unable to obtain survival information

  3. Patients call to refuse to participate in this project

  4. The quality of paraffin specimens can not meet the requirements of proteomeconcentration determination

Study Design

Total Participants: 300
Study Start date:
February 01, 2024
Estimated Completion Date:
February 28, 2025

Study Description

  1. The clinical diagnosis and treatment data of 300 cases of cervical neuroendocrine tumors were used for prognostic analysis.

(1) The diagnosis and treatment information of cervical neuroendocrine carcinoma in multiple hospitals was collected, including clinical and medical data such as age, preoperative HPV genotyping, preoperative biopsy pathological results, postoperative histopathological results, FIGO staging, prognosis and survival information, and follow-up of patients.

  1. Protein and other omics analysis was performed on paraffin tissues of 100 cases of cervical neuroendocrine tumors Paraffin samples collected from 100 cases of cervical neuroendocrine tumors were identified, processed and segmtioned, and protein concentration and proteome were determined to establish the molecular characteristics and prognostic targets of cervical neuroendocrine tumors.

Connect with a study center

  • Fujian Maternity and Child Health Hospital

    Fuzhou, Fujian 350001
    China

    Active - Recruiting

  • Fujian Provincial Hospital

    Fuzhou, Fujian
    China

    Active - Recruiting

  • Ningde Mindong Hospital

    Ningde, Fujian
    China

    Active - Recruiting

  • Putian City first Hospital

    Putian, Fujian
    China

    Active - Recruiting

  • The Second Affiliated Hospital of Fujian Medical University

    Quanzhou, Fujian
    China

    Active - Recruiting

  • Zhangzhou affiliated Hospital of Fujian Medical University

    Zhangzhou, Fujian 363000
    China

    Active - Recruiting

  • Maternal and Child Health Hospital of Hubei Province

    Wuhan, Hubei
    China

    Active - Recruiting

  • Xiangya Hospital, Central South University

    Changsha, Hunan
    China

    Active - Recruiting

  • Jiangxi maternal and Child Health Hospital

    Nanchang, Jiangxi
    China

    Active - Recruiting

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