Long-Term Follow-up Study for Subjects With CHB Previously Treated With Imdusiran (AB729)

Last updated: November 25, 2024
Sponsor: Arbutus Biopharma Corporation
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Non-interventional

Clinical Study ID

NCT06277037
AB-729-204
  • Ages 20-70
  • All Genders

Study Summary

This is a long term follow-up study for chronic hepatitis B (CHB) subjects who have received imdusiran treatment in a prior clinical trial, stopped NA therapy during that trial, and remain off therapy. Subjects may enroll after completing the end of study visit (baseline visit within 12 weeks ± 1 week from the end of study [EOS] visit) from their imdusiran clinical trial (the "parent study"). No interventions will be performed in this study other than blood sample collections, review of current medications, and reporting of any adverse events related to study procedures or NA therapy if restarted. Study participation will be for approximately 2 years (to complete a total of at least 3 years of follow-up while off NA therapy, inclusive of parent study participation).

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  • Have participated in a prior imdusiran clinical trial,

  • Have discontinued NA therapy in that trial and remain off NA therapy,

  • Have completed less than 3 years of follow-up visits after NA discontinuation in theparent study.

  • Have the ability to review and provide signed informed consent which includescompliance with all protocol-specified visit schedules and requirements.

Exclusion

Exclusion Criteria:

  • Not applicable

Study Design

Total Participants: 50
Treatment Group(s): 1
Primary Treatment: Non-interventional
Phase:
Study Start date:
July 11, 2024
Estimated Completion Date:
October 30, 2029

Connect with a study center

  • The Alfred Hospital

    Melbourne, Victoria 3004
    Australia

    Active - Recruiting

  • Fiona Stanley Hospital

    Murdoch, 6150
    Australia

    Site Not Available

  • Prince of Wales Hospital

    Shatin, New Territories
    Hong Kong

    Active - Recruiting

  • Queen Mary Hospital

    Hong Kong,
    Hong Kong

    Active - Recruiting

  • Pusan National University Hospital

    Busan, Seogu 49241
    Korea, Republic of

    Site Not Available

  • Asan Medial Center

    Seoul, 05505
    Korea, Republic of

    Site Not Available

  • Arensia Exploratory Medicine Moldova

    Chisinau,
    Moldova, Republic of

    Active - Recruiting

  • Changhua Christian Hospital

    Changhua city, 600566
    Taiwan

    Active - Recruiting

  • Chia-Yi Christian Hospital

    Chiayi City, 60002
    Taiwan

    Active - Recruiting

  • E-Da Hospital

    Kaohsiung, 82445
    Taiwan

    Active - Recruiting

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung, 80756
    Taiwan

    Active - Recruiting

  • Taichung Veterans General Hospital

    Taichung, 40705
    Taiwan

    Active - Recruiting

  • Chang Gung Medical Foundation Linkou

    Taoyuan, 33305
    Taiwan

    Active - Recruiting

  • University Hospital of Wales, Cardiff

    Cardiff, CF144XW
    United Kingdom

    Site Not Available

  • King's College Hospital

    London, SE59RS
    United Kingdom

    Site Not Available

  • Royal London Hospital

    London, E11FR
    United Kingdom

    Site Not Available

  • Research and Education Inc.

    San Diego, California 92105
    United States

    Active - Recruiting

  • University of Miami Miller School of Medicine

    Miami, Florida 33136
    United States

    Site Not Available

  • Infectious Disease Care

    Hillsborough, New Jersey 08844
    United States

    Active - Recruiting

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