Application of Ultra-high Frequency Ultrasonography (UHFUS) to the Study of Gingival Tissues

Last updated: March 30, 2025
Sponsor: University of Pisa
Overall Status: Active - Recruiting

Phase

N/A

Condition

Periodontitis

Treatment

Performance of ultrasonographic scan

Clinical Study ID

NCT06480825
7935870439
  • Ages 18-70
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Gingival inflammation triggered by the accumulation of bacterial is the primary risk factor for the development of periodontitis. Clinically, localized signs of inflammation limited to the gingiva, presence of significant bacterial plaque load, and stable attachment levels on the periodontium can be observed in course of gingivitis. The aim of the present study is to compare clinical aspects of gingival tissue in healthy patients versus patients with gingivitis to assess the ultrastructural variations present in course of inflammation.

Patients with gingivitis and healthy controls will be enrolled. All patients will undergo ultra-high frequency ultrasonographic scans (70 MHz) of gingival tissue on three areas per dental arch (anterior, middle right, middle left). Gingival thickness, echogenicity, and vascularization assessed through resisitive index will be evaluated.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • males or females of age > 18 years

  • presence of at least 20 teeth

  • full-mouth plaque score (FMPS) >50%

  • FMBS >30%

  • ability and willingness to give informed consent

Exclusion

Exclusion Criteria:

  • pregnancy or breastfeeding

  • pharmacological treatment with antinflammatory drugs, statins, or either local orsystemic antibiotics (within the previous 30 days)

  • smoking habit

  • dental or periodontal condition requiring immediate treatment

  • refusal to be enrolled in the study

Study Design

Total Participants: 40
Treatment Group(s): 1
Primary Treatment: Performance of ultrasonographic scan
Phase:
Study Start date:
April 02, 2024
Estimated Completion Date:
July 31, 2025

Connect with a study center

  • Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University Hospital of Pisa

    Pisa,
    Italy

    Active - Recruiting

  • University of Pisa

    Pisa, 56126
    Italy

    Active - Recruiting

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