Study to Assess the Efficacy, Safety, and Tolerability of NOC-110 in Adults with Refractory or Unexplained Chronic Cough

Inclusion Criteria:

• Refractory or unexplained chronic cough for ≥ 12 months.

• Women of childbearing potential agree to follow the protocol specified contraceptive

• guidance during the study.

• Males who are not vasectomized must agree to use the contraceptive methods definedin the protocol.

• Able to provide Informed Consent.

Exclusion Criteria:

• Previous exposure to taplucainium (formerly NTX-1175) or known allergy orhypersensitivity to taplucainium, its excipients/metabolites, or related compounds.

• Participants who are currently participating in another drug or device clinicalstudy

• Participants who have participated in an Acute or Chronic Cough investigationalstudy within 60 days before the start of the Screening.

• Current diagnosis of chronic obstructive pulmonary disease, bronchiectasis,unexplained pulmonary fibrosis, hemoptysis, bronchial asthma, or other pulmonarydisease.

• Respiratory tract infection within 4 weeks of Screening or during screening period.

• Any female who is pregnant or lactating or wishing to become pregnant.

• Donation of > 1 Unit (450 milliliter or more) of blood within 90 days prior to thefirst dosing.

• Alcohol or drug use disorder within the past 2 years.

• Current smoker/vaper or individuals who have given up smoking within the past 6months, and/or those with >20 pack-year smoking history.

• Current opiate/opioid use or medical history of opiate/opioid use disorder. Historyof concurrent malignancy or recurrence of malignancy in the last 2 years.

• Body Mass Index of ≥40 kg/m2.

• Positive results for human immunodeficiency virus, hepatitis B, or hepatitis Cvirus.

• Unable to refrain from the use of medications and treatments that can impact coughduring the study.

• Have clinically significant history or evidence of poorly controlled cardiovascular,respiratory, hepatic, renal, gastrointestinal, endocrine, neurological,immunological, or psychiatric disorder(s).