Phase
Condition
Lymphoma, B-cell
Lymphoma
Treatment
DZD8586
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Participants who meet all the following criteria:
Male and female ≥ 18 years of age.
ECOG performance status 0-2.
Histologically confirmed recurrent or refractory DLBCL.
Adequate bone marrow reserve and organ system functions.
Willing to comply with contraceptive restrictions
Exclusion
Exclusion Criteria:
Participants who meet any of the following criteria:
CNS involvement
Stem cell transplantation, cell therapy, or gene therapy within 90 days. Approvedsmall molecule therapy within 5 half-lives. Monoclonal antibodies and antibody-drugconjugates within 28 days.
Major surgery or significant traumatic injury within 4 weeks. Live attenuatedvaccines or viral vector vaccines within 4 weeks.
Take vitamin K antagonists or take more than 2 anticoagulants or antiplatelet drugsat the same time. Take proton pump inhibitors or strong CYP3A inhibitors orinducers.
Active infection.
Clinically significant cardiac disorders. History of thrombotic diseases, stroke orintracranial hemorrhage within 6 months.
Nausea and vomiting not controlled or chronic gastrointestinal diseases, unable toswallow the formulated product or previous bowel resection that would precludeadequate absorption.
Another malignancy within 2 years prior to enrollment with the exception ofadequately treated in-situ carcinoma of the cervix, uterus, basal or squamous cellcarcinoma or non-melanomatous skin cancer.
Women who are breast feeding.
History of hypersensitivity to active or inactive excipients of DZD8586 or drugswith a similar chemical structure or class.
Study Design
Connect with a study center
Research Site
Hefei, Anhui 230031
ChinaActive - Recruiting
Research Site
Beijing, Beijing 100083
ChinaActive - Recruiting
Research Site
Guangzhou, Guangdong 510060
ChinaActive - Recruiting
Research Site
Nanning, Guangxi 530016
ChinaActive - Recruiting
Research Site
Zhengzhou, Henan 450003
ChinaActive - Recruiting
Research Site
Wuhan, Hubei 430023
ChinaActive - Recruiting
Research Site
Changsha, Hunan 410031
ChinaActive - Recruiting
Research Site
Nanjing, Jiangsu 210009
ChinaSite Not Available
Research Site
Dalian, Liaoning 116021
ChinaSite Not Available
Research Site
Jinan, Shandong 250117
ChinaActive - Recruiting
Research Site
Linyi, Shandong 276002
ChinaSite Not Available
Research Site
Xi'an, Shanxi 710061
ChinaActive - Recruiting
Research Site
Chengdu, Sichuan 610041
ChinaActive - Recruiting
National Clinical Research Center for Blood Diseases, Blood Disease Hospital & Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College
Tianjin, Tianjin 300020
ChinaActive - Recruiting
Research Site
Tianjin, Tianjin 300181
ChinaActive - Recruiting
Research Site
Hangzhou, Zhejiang 310009
ChinaActive - Recruiting
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