Respiratory Training in Friedreich's Ataxia

Last updated: September 10, 2024
Sponsor: University of Florida
Overall Status: Active - Recruiting

Phase

N/A

Condition

Spinocerebellar Disorders

Friedreich's Ataxia

Dyskinesias

Treatment

Respiratory Strength Training (RST)

Clinical Study ID

NCT06539598
IRB202401099
  • Ages 18-65
  • All Genders

Study Summary

This is a prospective interventional study of patients with Friedreich's Ataxia that receive respiratory strength training for a period of 12 weeks with two research visits at the beginning and at the end of the study period. Visits include swallowing evaluation with fiberoptic endoscopic evaluation of swallowing, pulmonary function testing, surface electromyography and patient surveys.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • confirmed genetic testing of Friedreich's Ataxia

  • have an overall DIGEST score of 1 or higher based on FEES screening

  • are able to perform pulmonary function testing

Exclusion

Exclusion Criteria:

  • have been on antibiotics within 15 days prior to baseline screening.

  • have been prescribed systemic corticosteroids or neuromuscular blocking agentswithin 15 days of the baseline screening

  • have an allergy or contraindication to topical lidocaine or oxymetazoline

  • have any other concurrent medical condition which, in the opinion of theinvestigators, would make the subject inappropriate to participate in testing orrespiratory exercise

Study Design

Total Participants: 8
Treatment Group(s): 1
Primary Treatment: Respiratory Strength Training (RST)
Phase:
Study Start date:
August 29, 2024
Estimated Completion Date:
March 31, 2025

Connect with a study center

  • Clinical Research Center

    Gainesville, Florida 32610
    United States

    Active - Recruiting

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