An Open-label Study on the Clinical Efficacy of rTMS Intervention in PD

Inclusion Criteria:

1. Age ≥40 years old

2. Meet Movement Disorder Society standards;

3. Have no history of drug adjustment within 4 weeks before and during treatment;

4. The MDS-UPDRS Ⅲ score ≥8, and the Hoehn-Yahr rating is 1-4

5. MMSE ≥24，able to cooperate with the completion of behavioral tests and transcranialmagnetic stimulation therapy.

Exclusion Criteria:

1. Head MRI/CT ruled out focal brain injury or severe leukoencephalopathy (Fazekasgrade 3);

2. Various secondary parkinsonism syndromes (vascular parkinsonism, Parkinsonismcombined with parkinsonism, drug parkinsonism, etc.);

3. Severe craniocerebral trauma, received craniocerebral surgery or deep brainstimulation treatment;

4. There are ferromagnetic implants in the body, such as cochlear implants, cardiacpacemakers, etc.

5. The person or first-degree relatives have a history of epilepsy, unexplained loss ofconsciousness, or are taking anticonvulsant drugs to treat epileptic seizures;

6. Diagnosed with a neuropsychiatric disorder other than PD

7. Have a history of drug abuse or drug use;

8. Participants in any clinical trial within the previous 6 month;

9. Pregnant/lactating women or subjects (including men) who have a birth plan within 6months;

10. Other conditions deemed unsuitable for inclusion by the investigator.