Effect of Exercise on Clinical Symptoms, Cognitive Performance, and Quality of Life in Schizophrenia Patients Treated With Clozapine

Last updated: August 24, 2024
Sponsor: Dr. Lutfi Kirdar Kartal Training and Research Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Psychosis

Tourette's Syndrome

Mood Disorders

Treatment

physical exercise

Clinical Study ID

NCT06573320
Keah
  • Ages 18-65
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This prospective study aims to investigate the effects of exercise on clinical symptoms, cognitive performance, and quality of life in schizophrenia patients treated with Clozapine.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients treated who were diagnosed with schizophrenia according to DSM-V criteriaby psychiatrist at the Turkish Ministry of Health Kartal Dr. Lütfi Kırdar CityHospital

  • using a therapeutic dose of 300-500 mg/day of clozapine,

Exclusion

Exclusion Criteria:

  • pregnancy

Study Design

Total Participants: 60
Treatment Group(s): 1
Primary Treatment: physical exercise
Phase:
Study Start date:
March 14, 2024
Estimated Completion Date:
August 31, 2024

Study Description

The first developed atypical antipsychotic is clozapine. Its efficacy has been demonstrated in individuals with schizophrenia who have insufficient response to other antipsychotic therapies; nonetheless, its adverse effect profile is extensive. Among the antipsychotic medications now available, clozapine is not utilized as a first-line therapy because of major side effects such agranulocytosis. Increased salivation, sleepiness, weight gain, changes in blood pressure (sometimes an increase, sometimes a drop), elevated heart rate, dizziness, exhaustion, constipation, fever, and nocturnal enuresis are common adverse effects of clozapine usage.

Connect with a study center

  • Kartal Dr Lütfi Kırdar Şehir Hastanesi

    İstanbul,
    Turkey

    Active - Recruiting

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