SCAD : a Registry of Spontaneous Coronary Artery Dissection

Last updated: October 28, 2024
Sponsor: European Society of Cardiology
Overall Status: Active - Recruiting

Phase

N/A

Condition

Vascular Diseases

Chest Pain

Occlusions

Treatment

There are no interventions as the study is purely observational.

Clinical Study ID

NCT06601270
SCAD registry
  • Ages > 18
  • All Genders

Study Summary

Spontaneous coronary artery dissection (SCAD) is an increasingly recognised cause of non-atherosclerotic acute coronary syndromes (ACS), predominantly afflicting young women without conventional atherosclerotic risk factors. Knowledge of SCAD has advanced considerably in the last few years as a result of data from a number of local and national registries 1-6. Like all rarer diseases however, a better understanding of SCAD will require international collaboration. At present, there is no European or International SCAD registry despite increasing recognition that there are key differences in the diagnosis, interventional and medical management of SCAD compared with conventional atherosclerotic ACS. The ESC-ACCA Study Group on Spontaneous Coronary Artery Dissection supported by the European Observational Research Programme will now build the first pan-European SCAD registry to advance our understanding of current management of this condition, inform guidelines, educate clinical colleagues and advance research.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patient having signed an Informed Consent

  • Patient aged 18 years and over

  • SCAD clinical diagnosis within the past 10 years and available coronary angiographicimagery

Exclusion

Exclusion Criteria:

  • Patient unwilling or unable to consent

  • Patients with iatrogenic or atherosclerotic coronary dissection

Study Design

Total Participants: 1500
Treatment Group(s): 1
Primary Treatment: There are no interventions as the study is purely observational.
Phase:
Study Start date:
January 30, 2021
Estimated Completion Date:
October 31, 2027

Study Description

Observational, multicentre, international retrospective and prospective cohort study.

Since this is an observational study, a formal sample size is not necessary. At least 500 prospectively recruited patients and 500 historical cases will be enrolled.

Patient data will be collected at the following time-points:

  • First SCAD event visit (retrospectively on chart review)

  • First follow-up: at time of enrolment

  • Yearly follow-up: up to 1, 2, 3, 4 and 5 years post enrolment or until study completion

Approximately 30 countries and 120 sites will participate in this registry.

Connect with a study center

  • ICBA - Instituto Cardiovascular de Buenos Aires

    Buenos Aires,
    Argentina

    Active - Recruiting

  • Medical University of Innsbruck, Internal Medicine III

    Innsbruck,
    Austria

    Active - Recruiting

  • Klinik Landstrasse

    Vienna,
    Austria

    Active - Recruiting

  • Klinik Ottakring

    Vienna,
    Austria

    Active - Recruiting

  • Medical University of Vienna

    Vienna,
    Austria

    Active - Recruiting

  • Landesklinikum Wiener Neustadt

    Wiener Neustadt,
    Austria

    Active - Recruiting

  • AZ Sint jan, current president of Belgian ACCA

    Bruges,
    Belgium

    Active - Recruiting

  • Cliniques Universitaires Saint-Luc (UCL)

    Brussels,
    Belgium

    Active - Recruiting

  • Universitair Ziekenhuis Brussels

    Brussels,
    Belgium

    Site Not Available

  • Antwerp University Hospital

    Edegem,
    Belgium

    Active - Recruiting

  • Ziekenhuis Oost Limburg, Interventional cardiology/Coronary Care

    Genk,
    Belgium

    Active - Recruiting

  • AZ Sint Lucas hospital

    Gent,
    Belgium

    Site Not Available

  • Ghent University Hospital

    Gent,
    Belgium

    Active - Recruiting

  • University Hospitals Leuven

    Leuven,
    Belgium

    Site Not Available

  • CHR La Citadelle

    Liège,
    Belgium

    Active - Recruiting

  • Les cliniques Saint Pierre

    Ottignies,
    Belgium

    Site Not Available

  • AZ Delta

    Roeselare,
    Belgium

    Active - Recruiting

  • AZ Nikolaas

    Sint-Niklaas,
    Belgium

    Active - Recruiting

  • Clinical Center University of Sarajevo

    Sarajevo,
    Bosnia and Herzegovina

    Active - Recruiting

  • Hospital Israelita Albert Einstein

    Sao Paulo,
    Brazil

    Active - Recruiting

  • Instituto do Coração do HCFMUSP

    Sao Paulo,
    Brazil

    Active - Recruiting

  • Universidade Federal de São Paulo (UNIFESP)

    São Paulo,
    Brazil

    Active - Recruiting

  • University Hospital of Split (KBC Split)

    Split,
    Croatia

    Active - Recruiting

  • Nicosia General Hospital

    Nicosia,
    Cyprus

    Active - Recruiting

  • Nemocnice Pardubického kraje

    Pardubice,
    Czech Republic

    Active - Recruiting

  • Hospital Na Homolce

    Prague,
    Czech Republic

    Active - Recruiting

  • Aarhus University Hospital

    Aarhus,
    Denmark

    Active - Recruiting

  • Rigshospitalet

    Copenhagen,
    Denmark

    Active - Recruiting

  • Herlev and Gentofte Hospital

    Hellerup,
    Denmark

    Active - Recruiting

  • Odense University Hospital

    Odense,
    Denmark

    Active - Recruiting

  • CHRU Jean Minjoz

    Besançon,
    France

    Active - Recruiting

  • Gabriel Montpied Hospital - CHU Clermont-Ferrand

    Clermont-Ferrand,
    France

    Active - Recruiting

  • Hôpital de Chartres Louis Pasteur

    Le Coudray,
    France

    Active - Recruiting

  • Cardiovascular Hospital Louis Pradel - Hospices Civils de Lyon

    Lyon,
    France

    Active - Recruiting

  • Hôpital Jacques Cartier

    Massy,
    France

    Active - Recruiting

  • Hôpital Cardiologique du Haut Lévêque - Bordeaux University

    Pessac,
    France

    Active - Recruiting

  • Schüchtermann-Klinik Bad Rothenfelde

    Bad Rothenfelde,
    Germany

    Active - Recruiting

  • Vivantes Klinikum in Friedrichshain

    Berlin,
    Germany

    Active - Recruiting

  • University Heart and Vascular Center Hamburg Eppendorf

    Hamburg,
    Germany

    Active - Recruiting

  • Robert Bosch Hospital

    Stuttgart,
    Germany

    Active - Recruiting

  • Sotiria Thoracic Diseases Hospital

    Athens,
    Greece

    Active - Recruiting

  • General Hospital of Kozani

    Kozani,
    Greece

    Active - Recruiting

  • Tehran Heart Center

    Tehran,
    Iran, Islamic Republic of

    Active - Recruiting

  • Papa Giovanni XXIII Azienda Ospedaliera

    Bergamo,
    Italy

    Active - Recruiting

  • Policlinico Riuniti Foggia

    Foggia,
    Italy

    Active - Recruiting

  • Ospedale Policlinico San Martino IRCCS, Genova & Università di Genova

    Genoa,
    Italy

    Active - Recruiting

  • Presidio Ospedaliero Carlo Poma

    Mantua,
    Italy

    Active - Recruiting

  • ASST Grande Ospedale Niguarda

    Milan,
    Italy

    Active - Recruiting

  • Centro Cardiologico Monzino, IRCCS

    Milan,
    Italy

    Active - Recruiting

  • Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico

    Milan,
    Italy

    Active - Recruiting

  • Fondazione IRCCS San Gerardo dei Tintori

    Monza,
    Italy

    Active - Recruiting

  • Noordwest Ziekenhuisgroep / NorthWest Clinics

    Alkmaar,
    Netherlands

    Active - Recruiting

  • Amphia Hospital

    Breda,
    Netherlands

    Active - Recruiting

  • Radboud University Medical Centre

    Nijmegen,
    Netherlands

    Active - Recruiting

  • Auckland City Hospital - Green Lane Cardiovascular Service

    Auckland,
    New Zealand

    Active - Recruiting

  • Haukeland University Hospital - Invasive cardiology

    Bergen,
    Norway

    Active - Recruiting

  • Institute of Cardiology - Department of Interventional Cardiology and Angiology

    Warsaw,
    Poland

    Active - Recruiting

  • Hospital Fernando Fonseca

    Amadora,
    Portugal

    Active - Recruiting

  • Hospital de Braga

    Braga,
    Portugal

    Active - Recruiting

  • Centro Hospitalar Tondela Viseu

    Tondela,
    Portugal

    Active - Recruiting

  • Hospital do Espirito Santo de Evora

    Évora,
    Portugal

    Active - Recruiting

  • University Hospital Centre Bezanijska Kosa

    Belgrade,
    Serbia

    Active - Recruiting

  • Cardiology Clinic, UCC Nis

    Nis,
    Serbia

    Active - Recruiting

  • National University Heart Centre Singapore

    Singapore,
    Singapore

    Active - Recruiting

  • Stredoslovensky ustav srdcovych a cievnych chorob a.s

    Banska Bystrica,
    Slovakia

    Active - Recruiting

  • Hospital Universitario de la Princesa

    Madrid,
    Spain

    Active - Recruiting

  • William Harvey Hospital

    Ashford,
    United Kingdom

    Active - Recruiting

  • Glan Clwyd Hospital

    Bodelwyddan,
    United Kingdom

    Active - Recruiting

  • Bournemouth Hospital

    Bournemouth,
    United Kingdom

    Active - Recruiting

  • Bristol Heart Institute

    Bristol,
    United Kingdom

    Active - Recruiting

  • University Hospitals

    Leicester,
    United Kingdom

    Active - Recruiting

  • Royal Brompton & Chelsea & Westminster Hospital

    London,
    United Kingdom

    Site Not Available

  • Royal Free Hospital

    London,
    United Kingdom

    Active - Recruiting

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