Electroacupuncture Combined With Self-administered Acupressure for the Prevention of Capecitabine-Associated Hand-Foot Syndrome

Inclusion Criteria:

1. Sign a written informed consent form;

2. Male or female ≥ 18 years old;

3. Patients with gastrointestinal cancer or breast cancer who are diagnosed with cancerby pathology will receive capecitabine treatment for the first time according to thelabel;

4. The performance status of the Eastern Cancer Collaboration Group is 0-2;

5. Palliative or adjuvant chemotherapy with capecitabine (combination or monotherapy,minimum daily total dose of capecitabine 2000 mg/m^2);

6. Expected lifespan ≥ 3 months;

7. Laboratory requirements: platelet count ≥ 100 × 10^9/L, white blood cellcount>3.0 × 10^9/L, hemoglobin ≥ 10.0 g/dL, normal liver and kidneyfunction;

8. Adequate contraception.

Exclusion Criteria:

1. Previous use of capecitabine or liposome doxorubicin or any other tyrosine kinaseinhibitor that may induce HFS (such as sorafenib, sunitinib, and apatinib) forchemotherapy;

2. The initial dose of capecitabine is less than 800mg/m^2;

3. Radiation therapy or surgery should be performed within 4 weeks before the start oftreatment;

4. Skin diseases that may interfere with clinical trial results;

5. Known drug/alcohol abuse;

6. Pregnant women or lactating patients;

7. Participate in another clinical trial and the patient has received theinvestigational drug within the last 30 days prior to the start of treatment (i.e.follow-up in the previous trial was not exclusive);

8. Known patients who are afraid of electroacupuncture stimulation or allergic tostainless steel needles or any component of capecitabine;

9. Receive any acupuncture and moxibustion treatment ,there is lymphedema in the areastimulated by acupuncture;

10. Patients with any chemotherapy- or radiotherapy-related toxicities that have notsubsided to grade 2 or lower will be excluded, except for stable sensory neuropathy.

11. Any unresolved skin toxicity caused by previous chemotherapy or radiotherapy, exceptfor hair loss, will also be grounds for exclusion.