TeleNEURO-Rehabilitation Systems for Neurodegenerative Conditions: the FIT4TeleNEURO Pragmatic Trial

Inclusion Criteria:

• diagnosis of probable PD according to MDS criteria (Postuma et al., 2015) in stagingbetween 1 and 3 on the Hoehn & Yahr scale (Goetz et al., 2004) or diagnosis of MSaccording to the criteria of MC Donald 2010 (Polman et al., 2011) with disabilitylevel at the Expanded Disability Status Scale EDSS (Kurtzke, 1983) ≤ 4.5;

• age between 25 and 85 years;

• preserved cognitive level at the Montreal Cognitive Assessment test (MoCA test >15.5) (Santangelo et al., 2015);

• no rehabilitation program in place at the time of enrolment;

• stable drug treatment (last three month) with L-Dopa or dopamine agonists (PD group)or Disease Modifying Therapies (DMTs) (MS group).

Exclusion Criteria:

• presence of comorbidities that might prevent patients from undertaking a safe homeprogram or determining clinical instability (i.e., severe orthopedic or severecognitive deficits);

• presence of major psychiatric complications or personality disorders;

• presence of severe impairment of visual and/or acoustic perception;

• falls resulting in injuries or more than 2 falls in the 6 months prior torecruitment (PD and MS groups).

• pregnancy

• relapse ongoing/at least 3 months since the last relapse (MS group);

• presence of "frequent" freezing as recorded at the administration of Section II (daily life activity) of the UPDRS (score ≥ 3) (PD group);

• EDSS-FS (cerebellar function) ≥ 3 (MS group).