Optimal PERioperative Antiplatelet Therapy Investigation ON Abdominal Surgery After Coronary Stent Implantation

Last updated: February 9, 2025
Sponsor: Kyoto University
Overall Status: Active - Recruiting

Phase

4

Condition

N/A

Treatment

Aspirin

Aspirin interruption

Clinical Study ID

NCT06723145
Y0211
24ek0210198h0001
  • Ages > 20
  • All Genders

Study Summary

The purpose of this study is to evaluate the impact of perioperative aspirin continuation on clinical outcomes in patients with a history of coronary stent implantation who are scheduled for abdominal surgery.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients with a history of coronary stenting and scheduled for abdominal surgery

  • Patients on a single antiplatelet agent

Exclusion

Exclusion Criteria:

  • Patients on dual antiplatelet therapy (DAPT)

  • Patients on anticoagulation therapy

  • Patients with a history of stent thrombosis

  • Patients with CHADS2 score >= 5

  • Patients at extremely high risk of bleeding and unable to continue preoperativeaspirin

  • Patients incapable of consent, including those under 20 years of age

  • Other patients for whom either discontinuation or continuation of antiplateletagents is deemed inappropriate by the attending physician

Study Design

Total Participants: 1200
Treatment Group(s): 2
Primary Treatment: Aspirin
Phase: 4
Study Start date:
January 20, 2025
Estimated Completion Date:
March 31, 2027

Study Description

PCI with coronary stent implantation is performed for a huge number of patients with coronary artery disease. Approximately 20% of these patients undergo non-cardiac surgery within three years after PCI. However, there is a scarcity of clinical evidence regarding the efficacy of perioperative aspirin continuation on cardiovascular events.

Connect with a study center

  • Kyoto University Hospital

    Kyoto, 606-8507
    Japan

    Active - Recruiting

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