Efficacy Study of EVO301 in Moderate to Severe Atopic Dermatitis

Last updated: December 2, 2025
Sponsor: Evommune, Inc.
Overall Status: Completed

Phase

2

Condition

Allergy

Dermatitis, Atopic

Atopic Dermatitis

Treatment

EVO301

Placebo

Clinical Study ID

NCT06723405
EVO301-AD001
  • Ages > 18
  • All Genders

Study Summary

This is a Phase 2a efficacy and safety study of EVO301 for the treatment of adults with atopic dermatitis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Males or non-pregnant, non-lactating females, age 18 years or older

  2. Chronic atopic dermatitis for at least 6 months

  3. BSA of AD involvement of at least 10%

  4. EASI score of at least 16.

Exclusion

Exclusion Criteria:

  1. Significant AD flare with 4 weeks

  2. Use of biologic therapy within 12 weeks

  3. Regular use of tanning booth within 4 weeks

  4. Skin condition that could interfere with study assessments

Study Design

Total Participants: 71
Treatment Group(s): 2
Primary Treatment: EVO301
Phase: 2
Study Start date:
February 13, 2025
Estimated Completion Date:
November 17, 2025

Study Description

This is a Phase 2a efficacy and safety study of intravenous EVO301 in adults with moderate to severe atopic dermatitis.

Connect with a study center

  • Cornerstone Dermatology

    Coorparoo, QLD 4151
    Australia

    Site Not Available

  • Cornerstone Dermatology

    Coorparoo 2170435, QLD 4151
    Australia

    Site Not Available

  • Momentum Clinical Research Darlinghurst

    Darlinghurst, NSW 2010
    Australia

    Site Not Available

  • Momentum Clinical Research Darlinghurst

    Darlinghurst 2169378, NSW 2010
    Australia

    Site Not Available

  • Optimal Clinical Trials

    Auckland, 1010
    New Zealand

    Active - Recruiting

  • Optimal Clinical Trials North

    Auckland, 0632
    New Zealand

    Active - Recruiting

  • Pacific Clinical Research Network (PCRN) Auckland

    Auckland, 0622
    New Zealand

    Site Not Available

  • Optimal Clinical Trials

    Auckland 2193733, 1010
    New Zealand

    Site Not Available

  • Optimal Clinical Trials North

    Auckland 2193733, 0632
    New Zealand

    Site Not Available

  • Pacific Clinical Research Network (PCRN) Auckland

    Auckland 2193733, 0622
    New Zealand

    Site Not Available

  • Pacific Clinical Research Network (PCRN) Christchurch

    Christchurch, 8013
    New Zealand

    Site Not Available

  • Pacific Clinical Research Network (PCRN) Christchurch

    Christchurch 2192362, 8013
    New Zealand

    Site Not Available

  • Momentum Clinical Research Dunedin

    Dunedin, 9016
    New Zealand

    Site Not Available

  • Momentum Clinical Research Dunedin

    Dunedin 2191562, 9016
    New Zealand

    Site Not Available

  • Clinical Trials New Zealand Ltd

    Hamilton, 3204
    New Zealand

    Site Not Available

  • Clinical Trials New Zealand Ltd

    Hamilton 2190324, 3204
    New Zealand

    Site Not Available

  • Momentum Clinical Research Lower Hutt

    Hutt Central, 5010
    New Zealand

    Site Not Available

  • Pacific Clinical Research Network (PCRN) Tasman

    Nelson, 7011
    New Zealand

    Site Not Available

  • Pacific Clinical Research Network (PCRN) Tasman

    Nelson 2186280, 7011
    New Zealand

    Site Not Available

  • Momentum Clinical Research Kapiti

    Paraparaumu, 5032
    New Zealand

    Site Not Available

  • Momentum Clinical Research Kapiti

    Paraparaumu 2184904, 5032
    New Zealand

    Site Not Available

  • Momentum Clinical Research Pukekohe

    Pukekohe, 2120
    New Zealand

    Site Not Available

  • Momentum Clinical Research Pukekohe

    Pukekohe 6231587, 2120
    New Zealand

    Site Not Available

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