Phase
Condition
Leukemia
Platelet Disorders
Anemia
Treatment
Exercise
Control
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
A diagnosis of either Lower-risk of Myelodysplastic Syndrome or Clonal Cytopenia ofundetermined significance(WHO 2022 Classification)
Written informed consent prior to study procedures
Performance status ≤ 2
Age > 18 years old
Exclusion
Exclusion Criteria:
Physically not able to undergo exercise intervention (e.g., arthrosis, physicaldisabilities)
Exercising on a regular basis (i.e., participants must score in the category "low"when screening with International Physical Activity Questionnaire-Short Form;IPAQ-SF27)
Unwillingness to undergo exercise intervention
Use of metformin
Treatment with chemotherapy, therapeutic radiation, or immunosuppressive therapywithin the last year
Treatment with hypomethylating agents
Any absolute contraindication to undergo cardiopulmonary exercise testing accordingto working papers from American Heart Association and Danish Society of Cardiology
Hemoglobin levels < 5.5 mmol OR <6.5 mmol and simultaneous cardiac insufficiency ORpacemaker.
Blood transfusion-dependent ≥ 8 units of red blood cell transfusion in 16 weeks (IWG 2018-criteria)
Uncontrolled co-morbidity
Study Design
Connect with a study center
Rigshospitalet
Copenhagen,
DenmarkActive - Recruiting
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