Phase
Condition
Non-small Cell Lung Cancer
Treatment
No drug
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
The key inclusion criteria for this study are:
Age ≥18 years at signing informed consent form (ICF).
Pathologically documented unresectable and/or metastatic non-squamous NSCLC.
Documented any known activating HER2 mutation.
Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-2.
Patients who receive T-DXd based on physicians' discretion (Newly received or just have started the first dose no longer than 2 months before enrollment).
The key exclusion criteria for this study are:
- Previously treated with HER2-targeted/directed therapies, including:
tyrosine kinase inhibitors [TKIs] targeting HER2 mutations, except for pan-HER class TKIs.
an ADC, containing a chemotherapeutic agent targeting topoisomerase I
Has spinal cord compression or clinically active CNS metastases, defined as untreated and symptomatic, or requiring therapy with corticosteroids or anticonvulsants to control associated symptoms.
Any evidence of severe or uncontrolled systemic diseases, including uncontrolled hypertension active bleeding diatheses, etc.
Study Design
Study Description
Connect with a study center
Beijing Cancer Hospital
Beijing, 100142
ChinaSite Not Available
Cancer Hospital Chinese Academy of Medical Sciences
Beijing, 100021
ChinaSite Not Available
Peking University International Hospital
Beijing, 100125
ChinaSite Not Available
Hunan Second People's Hospital
Changsha, 410007
ChinaSite Not Available
Fujian Cancer Hospital
Fuzhou, 350014
ChinaSite Not Available
Affiliated Cancer Hospital and Institute of Guangzhou Medical University
Guangzhou, 510060
ChinaSite Not Available
The First Affiliated Hospital of Sun Yat-sen University
Guangzhou, 510062
ChinaSite Not Available
Zhejiang Cancer Hospital
Hangzhou, 310022
ChinaSite Not Available
Anhui Provincial Cancer Hospital
Hefei, 230031
ChinaSite Not Available
Cancer Hospital of Shandong First Medical University
Jinan, 250103
ChinaSite Not Available
First Affiliated Hospital of Shandong First Medical University
Jinan, 250014
ChinaSite Not Available
The First Affiliated Hospital of Jinzhou Medical University
Jinzhou, 121001
ChinaSite Not Available
The First Affiliated Hospital of Nanchang University
Nanchang, 330000
ChinaSite Not Available
Guangxi Medical University Cancer Hospital
Nanning, 541000
ChinaSite Not Available
Ruijin Hospital, Shanghai Jiaotong University School Of Medicine
Shanghai, 200025
ChinaSite Not Available
Zhongshan Hospital Fudan University
Shanghai, 200032
ChinaSite Not Available
The First Hospital of China Medical University
Shenyang, 110001
ChinaSite Not Available
Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen Center
Shenzhen, 518116
ChinaSite Not Available
The Fourth Hospital of Hebei Medical University
Shijiazhuang, 050011
ChinaSite Not Available
Shangxi Provincial Cancer Hospital
Taiyuan, 030013
ChinaActive - Recruiting
Shanxi Provincial Cancer Hospital
Taiyuan, 030013
ChinaSite Not Available
The First Affiliated Hospital of Xiamen University
Xiamen, 361102
ChinaSite Not Available
Henan Cancer Hospital
Zhengzhou, 450052
ChinaSite Not Available
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, 450052
ChinaSite Not Available
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