TQC2731 Clinical Trial for the Treatment of Severe Asthma With Injection

Inclusion Criteria:

• Sign the informed consent form before the trial to fully understand the purpose,process and possible adverse reactions of the trial;

• Age 18 ~ 75 years old, gender is not limited;

• Documented physician diagnosis of asthma at least 12 months prior to Visit 1;

• Subjects who received high-dose Inhaled Corticosteroids (ICS) in asthma controlmedications prescribed by their physicians at least 6 months prior to Visit 1;

• There must be a record of receiving a stable total daily dose of ICS at least 3months prior to visit 1;

• There must be a record of the use of other asthma control medications at a stabledose at least 3 months prior to visit 1; For subjects taking maintenance oralhormones, the dose of oral hormones is up to 10mg prednisone per day or 20mg everyother day (or equivalent) and must be stable for at least 30 days prior to visit 1and during treatment.

• Documented at least 2 asthma exacerbations in the 12 months prior to Visit 1 and nomajor asthma exacerbation events in the 1 month prior to signing informed.

Exclusion Criteria:

• Have a clinically significant lung disease other than asthma；

• Pre-existing autoimmune disease;

• A history of known or suspected immunosuppression, including a history of invasiveopportunistic infections;

• Any disease that has not been determined to be stable by the investigator；

• Cancer history: Patients with basal cell carcinoma, skin localized squamous cellcarcinoma, or cervical carcinoma in situ are eligible to be enrolled in this studyif they had completed curative therapy for at least 12 months prior to visit 1.Patients with other malignancies who had completed curative treatment for at least 5years prior to visit 1 could be enrolled in the study.

• Current smoker or smoking history ≥10 pack-years (former smokers with smokinghistory <10 pack-years had quit smoking less than 6 months before interview 1);

• Other factors determined by the investigator that subjects were not suitable toparticipate in the study.