Predictors of Poor Prognosis in HFpEF

Inclusion Criteria:

1. Signed and data informed consent;

2. New York Heart Association (NYHA) class II-III heart failure;

3. Left ventricular ejection fraction > 50%;

4. Elevated LV filling pressures assessed by echocardiography at rest or at peakexercise.

Exclusion Criteria:

1. Evidence of myocardial ischemia during stress echocardiography;

2. Significant lesions of the main coronary arteries;

3. Genetic forms of HFpEF (HCM, amyloidosis, Fabry disease, glycogen storage diseasesetc.);

4. Peripartum cardiomyopathy, chemotherapy-induced cardiomyopathy, viral myocarditis,isolated right-sided HF without left-sided structural disease, constrictivepericarditis, significant pericardial effusion;

5. Significant lung disease (severe lung disease requiring home oxygen or chronic oralsteroid therapy);

6. Primary pulmonary artery hypertension;

7. Significant left-sided structural valve disease;

8. Anemia (Hb < 100 g/L);

9. Impaired renal function, defined as estimated glomerular filtration rate (eGFR) <30mL/min/1.73 m2 (CKD-EPI);

10. Non-cardiac conditions that complicate/exclude participation in the study;

11. Exacerbation of heart failure less than 3 months prior to study entry.