Efficacy of Selective Laser Trabeculoplasty Targeting Nasal Versus Inferior 180-degree

Last updated: February 24, 2025
Sponsor: Mayo Clinic
Overall Status: Active - Recruiting

Phase

N/A

Condition

Glaucoma

Open Angle Glaucoma

Treatment

Inferior 180° Selective Laser Trabeculoplasty (SLT)

Nasal 180° Selective Laser Trabeculoplasty (SLT)

Clinical Study ID

NCT06851546
24-008197
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study to optimize Selective Laser Trabeculoplasty (SLT) application when used in the management of open angle glaucoma (OAG)

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age 18 years and older

  • Ability to comprehend the study procedures and agreement to proceed with primary SLTtreatment

  • Diagnosis of primary or secondary open angle glaucoma or glaucoma suspects withocular hypertension

  • Bilateral disease

  • Pre-SLT IOP >21 mmHg measured at least twice during patient's lifetime with orwithout medication

  • Open angles with moderate to intense trabecular pigmentation

  • Mild to moderate visual field defects (24-2 standard mean deviations better than theSwedish interactive thresholding algorithm standard of 12 dB)

  • No adequate IOP control (low treatment compliance, substantial adverse effects witheyedrops, and at least 2 IOP measurements higher than the individualized target IOP)

Exclusion

Exclusion Criteria:

  • Unwilling or unable to give consent

  • Unable to attend scheduled post-operative visits

  • Previous history of either laser treatment or intraocular surgery, except fornon-complicated cataract surgery (performed >6 months before SLT)

  • History of ocular trauma

  • Narrow angles

  • Retinal detachment

  • Active iris neovascularization or active proliferative retinopathy

  • Active uveitis

  • Monocular patients

  • Current use of steroids (ocular, periocular, or systemic)

Study Design

Total Participants: 102
Treatment Group(s): 2
Primary Treatment: Inferior 180° Selective Laser Trabeculoplasty (SLT)
Phase:
Study Start date:
January 06, 2025
Estimated Completion Date:
December 17, 2025

Study Description

The purpose of this research is to determine the most effective method in using Selective Laser Trabeculoplasty (SLT) for lowering intraocular pressure (IOP) in patients with ocular hypertension or open-angle glaucoma. We will investigate the IOP lowering differences between nasal 180° SLT and inferior 180° SLT,. The second stage will assess the effect of repeating SLT in the opposite 180° sector after 3 months.

Connect with a study center

  • Eye Care Centre, Victoria General Hospital

    Halifax, Nova Scotia NS B3H 2Y9
    Canada

    Active - Recruiting

  • Mayo Clinic in Rochester

    Rochester, Minnesota 55905
    United States

    Active - Recruiting

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