Effect of Terlipressin for Intraoperative Blood Pressure Management in Kidney Transplantation

Last updated: March 17, 2025
Sponsor: Beijing Friendship Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Vascular Diseases

Dizzy/fainting Spells

Circulation Disorders

Treatment

terlipressin

Clinical Study ID

NCT06855758
2025-P2-023-01
  • Ages > 18
  • All Genders

Study Summary

Prospective double blind randomized controlled trial. By randomizing patients undergoing kidney transplantation into a conventional catecholamine drug (dobutamine) blood pressure maintenance group and a terlipressin-complexed dobutamine group, the investigators compared the effect of intraoperative blood pressure maintenance and the dosage of the vasoactive drug, postoperative graft function, delayed graft function, and other related complications between the two groups, in order to demonstrate whether the use of terlipressin for blood pressure regulation during kidney transplantation is superior to the existing treatments.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients with end-stage renal disease aged 18 years or above

Exclusion

Exclusion Criteria:

  • simultaneous multiple organ transplantation

  • known allergy to study medication

  • known pregnancy status

  • cancellation of surgery due to grafts or personal reasons

  • persistent severe preoperative hypertension that may not require intraoperativesupportive therapy with vasoactive medications

  • any other reason that the supervising physician or the anesthesiologist on dutythink the patient is not suitable for the study

Study Design

Total Participants: 150
Treatment Group(s): 1
Primary Treatment: terlipressin
Phase:
Study Start date:
March 06, 2025
Estimated Completion Date:
June 30, 2027

Connect with a study center

  • Beijing Friendship Hospital

    Beijing,
    China

    Active - Recruiting

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