A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension

Last updated: April 1, 2025
Sponsor: Kardigan, Inc.
Overall Status: Active - Recruiting

Phase

2

Condition

Williams Syndrome

Vascular Diseases

Stress

Treatment

Placebo

Tonlamarsen

Clinical Study ID

NCT06864104
TLA-201
  • Ages 18-80
  • All Genders

Study Summary

The purpose of this study is to evaluate the blood pressure-lowering effect of tonlamarsen in adult participants who, despite taking 2 or more antihypertensive medications, have not achieved their target blood pressure (BP).

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  • Age 18 to 80, body weight ≥ 50 kg

  • Has uncontrolled hypertension while receiving between 2 and 5 antihypertensivemedications prescribed for hypertension

  • Has mean office seated systolic blood pressure > 135 to ≤ 170 mmHg

Exclusion

Key Exclusion Criteria:

  • Has known history of secondary hypertension

  • Has documented history of poor adherence to antihypertensive medication

  • Has unstable/underlying known cardiovascular disease

  • Has abnormal thyroid function with clinical significance

Study Design

Total Participants: 700
Treatment Group(s): 2
Primary Treatment: Placebo
Phase: 2
Study Start date:
April 14, 2025
Estimated Completion Date:
December 20, 2027

Connect with a study center

  • Elite Clinical Studies

    Phoenix, Arizona 85018
    United States

    Active - Recruiting

  • Clinical Trials Research

    Lincoln, California 95648
    United States

    Active - Recruiting

  • Jacksonville Center for Clinical Research

    Jacksonville, Florida 32216
    United States

    Active - Recruiting

  • Progressive Medical Research

    Port Orange, Florida 32127
    United States

    Active - Recruiting

  • Clinical Investigation Specialists, Inc.

    Gurnee, Illinois 60031
    United States

    Active - Recruiting

  • DelRicht Clinical Research - New Orleans

    New Orleans, Louisiana 70115
    United States

    Active - Recruiting

  • Chear Center LLC

    Bronx, New York 10455
    United States

    Active - Recruiting

  • Health Concepts

    Rapid City, South Dakota 57702
    United States

    Active - Recruiting

  • Holston Medical Group

    Kingsport, Tennessee 37660
    United States

    Active - Recruiting

  • Juno Research, LLC

    Houston, Texas 77040
    United States

    Active - Recruiting

  • North Hills Medical Research Inc.

    North Richland Hills, Texas 76180
    United States

    Active - Recruiting

  • Sun Research Institute

    San Antonio, Texas 78215
    United States

    Active - Recruiting

  • Manassas Clinical Research Center

    Manassas, Virginia 20110
    United States

    Active - Recruiting

  • York Clinical Research LLC

    Norfolk, Virginia 23504
    United States

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.