Phase
Condition
Bronchiectasis
Emphysema
Chronic Bronchitis
Treatment
Tezepelumab
Placebo
Clinical Study ID
Ages 40-80 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
≥40 to ≤80 years old
COPD diagnosis ≥1 year,
Post-BD FEV1 ≥ 20% and ≤ 70% PN, FEV1/FVC <0.70 at screening
Triple (ICS+LABA+LAMA) or dual inhaled COPD therapy ≥3 consecutive months prior toV1
≥2 moderate or ≥1 severe COPD exacerbations in the prior year; At least 1 of 2moderate exacerbations must require the use of systemic corticosteroids
EOS ≥ 150 cells/μL during screening
CAT ≥15 at screening
Former or current smokers ≥10 pack-years
Exclusion
Exclusion Criteria:
Clin. important pulmonary disease or radiological findings suggestive of arespiratory disease other than COPD
Asthma, incl. pediatric, or ACOS
Any unstable disorder that can impact participants safety or study outcomes
Tuberculosis requiring treatment within 12 months prior V2
Malignancies current or past Concomitant therapies:
Macrolides (less than 6 months)
Systemic immuno-suppressive, -modulating medications
- LTOT >4.0 L/min or O2 saturation <89% despite LTOT
Study Design
Study Description
Connect with a study center
Research Site
Frankston, 3199
AustraliaSite Not Available
Research Site
Garran, 2605
AustraliaSite Not Available
Research Site
Spearwood, 6163
AustraliaSite Not Available
Research Site
Woodville South, 5011
AustraliaSite Not Available
Research Site
Genk, 3600
BelgiumSite Not Available
Research Site
Gent, 9000
BelgiumSite Not Available
Research Site
Jette, 1090
BelgiumSite Not Available
Research Site
Leuven, 3000
BelgiumSite Not Available
Research Site
Mechelen, 2800
BelgiumSite Not Available
Research Site
Namur, 5101
BelgiumSite Not Available
Research Site
Dupnitsa, 2600
BulgariaSite Not Available
Research Site
Lovech, 5500
BulgariaSite Not Available
Research Site
Pleven, 5804
BulgariaSite Not Available
Research Site
Plovdiv, 4003
BulgariaSite Not Available
Research Site
Ruse, 7000
BulgariaSite Not Available
Research Site
Sofia, 1756
BulgariaSite Not Available
Research Site
Stara Zagora, 6003
BulgariaSite Not Available
Research Site
Varna, 9000
BulgariaSite Not Available
Research Site
Veliko Tanovo, 5000
BulgariaSite Not Available
Research Site
Veliko Tarnovo, 5000
BulgariaSite Not Available
Research Site
Vidin, 3700
BulgariaSite Not Available
Research Site
Yambol, 8600
BulgariaSite Not Available
Research Site
Armenia, 630004
ColombiaSite Not Available
Research Site
Barranquilla, 080020
ColombiaSite Not Available
Research Site
Cali, 760042
ColombiaSite Not Available
Research Site
Ibague, 730006
ColombiaSite Not Available
Research Site
Manizales, 170004
ColombiaSite Not Available
Research Site
Medellin, 050022
ColombiaSite Not Available
Research Site
Medellín, 050030
ColombiaSite Not Available
Research Site
Aalborg, 9000
DenmarkSite Not Available
Research Site
Hvidovre, 2650
DenmarkSite Not Available
Research Site
Næstved, 4700
DenmarkSite Not Available
Research Site
Odense C, 5000
DenmarkSite Not Available
Research Site
Vejle, 7100
DenmarkSite Not Available
Research Site
Brest Cedex 2, 29609
FranceSite Not Available
Research Site
Lyon Cedex 04, 69317
FranceSite Not Available
Research Site
Marseille, 13915
FranceSite Not Available
Research Site
Montpellier Cedex 5, 34295
FranceSite Not Available
Research Site
Paris, 75014
FranceSite Not Available
Research Site
Paris Cedex 18, 75877
FranceSite Not Available
Research Site
Pessac, 33604
FranceSite Not Available
Research Site
Saint Herblain, 44800
FranceSite Not Available
Research Site
Athens, 11521
GreeceSite Not Available
Research Site
Heraklion, 71110
GreeceSite Not Available
Research Site
Ioannina, 45500
GreeceSite Not Available
Research Site
Patra, 26332
GreeceSite Not Available
Research Site
Thessaloniki, 57010
GreeceSite Not Available
Research Site
Hong Kong,
Hong KongSite Not Available
Research Site
Budapest, 1036
HungarySite Not Available
Research Site
Debrecen, 4032
HungarySite Not Available
Research Site
Edelény, 3780
HungarySite Not Available
Research Site
Gödöllő, 2100
HungarySite Not Available
Research Site
Hatvan, 3000
HungarySite Not Available
Research Site
Mosonmagyaróvár, 9200
HungarySite Not Available
Research Site
Nyíregyháza-Sóstóhegy, 4481
HungarySite Not Available
Research Site
Törökbálint, 2045
HungarySite Not Available
Research Site
Ashkelon, 78278
IsraelSite Not Available
Research Site
Haifa, 34362
IsraelSite Not Available
Research Site
Jerusalem, 00000
IsraelSite Not Available
Research Site
Kfar Saba, 4428164
IsraelSite Not Available
Research Site
Ramat Gan, 52621
IsraelSite Not Available
Research Site
Rehovot, 76100
IsraelSite Not Available
Research Site
Tel Aviv, 6423906
IsraelSite Not Available
Research Site
Akashi-shi, 674-0063
JapanSite Not Available
Research Site
Fukui-shi, 910-8526
JapanSite Not Available
Research Site
Fukuoka-shi, 811-1394
JapanSite Not Available
Research Site
Ishinomaki, 986-8522
JapanSite Not Available
Research Site
Kasuga-shi, 816-0864
JapanSite Not Available
Research Site
Kiyose-shi, 204-8585
JapanSite Not Available
Research Site
Kobe-shi, 650-0047
JapanSite Not Available
Research Site
Komatsu-shi, 923-8560
JapanSite Not Available
Research Site
Kure-shi, 737-8505
JapanSite Not Available
Research Site
Meguro-ku, 153-0051
JapanSite Not Available
Research Site
Minato-ku, 108-0073
JapanSite Not Available
Research Site
Miyazaki-shi, 889-1692
JapanSite Not Available
Research Site
Nagoya-shi, 457-8511
JapanSite Not Available
Research Site
Nerima-ku, 177-8521
JapanSite Not Available
Research Site
Ohta-ku, 143-0013
JapanSite Not Available
Research Site
Shinjuku-ku, 162-8655
JapanSite Not Available
Research Site
Shiogama City, 985-8506
JapanSite Not Available
Research Site
Takamatsu-shi, 760-0018
JapanSite Not Available
Research Site
Takatsuiki-shi, 569-1096
JapanSite Not Available
Research Site
Toshima-ku, 171-0014
JapanSite Not Available
Research Site
Ube, 755-8505
JapanSite Not Available
Research Site
Yokohama-shi, 236-0004
JapanSite Not Available
Research Site
Eindhoven, 5623 EJ
NetherlandsSite Not Available
Research Site
Maastricht, 6229 HX
NetherlandsSite Not Available
Research Site
Rotterdam, 3083 AN
NetherlandsSite Not Available
Research Site
Zutphen, 7207 AE
NetherlandsSite Not Available
Research Site
Auckland, 1051
New ZealandSite Not Available
Research Site
Hamilton West, 3204
New ZealandSite Not Available
Research Site
Tauranga, 3112
New ZealandSite Not Available
Research Site
Lima, LIMA 21
PeruSite Not Available
Research Site
Piura, 20001
PeruSite Not Available
Research Site
Benoni, 1501
South AfricaSite Not Available
Research Site
Cape Town, 7700
South AfricaSite Not Available
Research Site
Durban, 4093
South AfricaSite Not Available
Research Site
Somerset West, 7130
South AfricaSite Not Available
Research Site
Tygervalley, 7530
South AfricaSite Not Available
Research Site
Karlskrona, 371 79
SwedenSite Not Available
Research Site
Lund, 22185
SwedenSite Not Available
Research Site
Stockholm, 171 64
SwedenSite Not Available
Research Site
Örebro, 703 62
SwedenSite Not Available
Research Site
Bang Kra So, 11000
ThailandSite Not Available
Research Site
Bangkok, 10330
ThailandSite Not Available
Research Site
Hat Yai, 90110
ThailandSite Not Available
Research Site
Hatyai, 90110
ThailandSite Not Available
Research Site
Muang, 40002
ThailandSite Not Available
Research Site
Mueang, 20000
ThailandSite Not Available
Research Site
Rayong, 21000
ThailandSite Not Available
Research Site
Tempe, Arizona 85283
United StatesSite Not Available
Research Site
Redding, California 96001
United StatesActive - Recruiting
Research Site
San Diego, California 92108
United StatesActive - Recruiting
Research Site
Boynton Beach, Florida 33435
United StatesSite Not Available
Research Site
Clearwater, Florida 33765
United StatesSite Not Available
Research Site
Jacksonville, Florida 32209
United StatesSite Not Available
Research Site
Margate, Florida 33063
United StatesSite Not Available
Research Site
Miami, Florida 33155
United StatesSite Not Available
Research Site
Miami Lakes, Florida 33014
United StatesSite Not Available
Research Site
Ocala, Florida 34470
United StatesSite Not Available
Research Site
Palmetto Bay, Florida 33157
United StatesSite Not Available
Research Site
Adairsville, Georgia 30103
United StatesSite Not Available
Research Site
Atlanta, Georgia 30349
United StatesSite Not Available
Research Site
Fort Eisenhower, Georgia 30905
United StatesSite Not Available
Research Site
Savannah, Georgia 31406
United StatesSite Not Available
Research Site
Evansville, Indiana 47710
United StatesSite Not Available
Research Site
Indianapolis, Indiana 46268
United StatesSite Not Available
Research Site
Kansas City, Kansas 66160
United StatesSite Not Available
Research Site
Bowling Green, Kentucky 42101
United StatesSite Not Available
Research Site
Owensboro, Kentucky 42301
United StatesSite Not Available
Research Site
Baltimore, Maryland 21224
United StatesSite Not Available
Research Site
Potomac, Maryland 20854
United StatesSite Not Available
Research Site
Minneapolis, Minnesota 55425
United StatesSite Not Available
Research Site
Hannibal, Missouri 63401
United StatesSite Not Available
Research Site
Charlotte, North Carolina 28277
United StatesSite Not Available
Research Site
Fayetteville, North Carolina 28303
United StatesSite Not Available
Research Site
Oklahoma City, Oklahoma 73102
United StatesSite Not Available
Research Site
Tulsa, Oklahoma 74133
United StatesSite Not Available
Research Site
Grants Pass, Oregon 97527
United StatesSite Not Available
Research Site
Anderson, South Carolina 29621
United StatesSite Not Available
Research Site
Columbia, South Carolina 29204
United StatesSite Not Available
Research Site
Gaffney, South Carolina 29340
United StatesSite Not Available
Research Site
Spartanburg, South Carolina 29303
United StatesSite Not Available
Research Site
Union, South Carolina 29379
United StatesSite Not Available
Research Site
Rapid City, South Dakota 57702
United StatesSite Not Available
Research Site
Knoxville, Tennessee 37919
United StatesSite Not Available
Research Site
Boerne, Texas 78006
United StatesSite Not Available
Research Site
El Paso, Texas 79902
United StatesSite Not Available
Research Site
Houston, Texas 77008
United StatesSite Not Available
Research Site
Lewisville, Texas 75067
United StatesSite Not Available
Research Site
McKinney, Texas 75069
United StatesSite Not Available
Research Site
Colchester, Vermont 05446
United StatesSite Not Available
Research Site
Williamsburg, Virginia 23188
United StatesSite Not Available
Research Site
Everett, Washington 98208
United StatesSite Not Available
Research Site
Hanoi, 100000
VietnamSite Not Available
Research Site
Ho Chi Minh, 700000
VietnamSite Not Available
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