Changes in Perioperative Blood Volume and Fluid Distribution in Patients Undergoing Primary Total Hip Replacement.

Last updated: March 17, 2025
Sponsor: Copenhagen University Hospital, Hvidovre
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT06888908
H-24062107
  • Ages > 18
  • All Genders

Study Summary

Clinical assessment of bleeding and calculation of perioperative blood loss do not provide an accurate estimate of blood volume. This makes rational fluid management difficult, which is of high importance for patient-related outcomes. The availability of carbon monoxide(CO)-rebreathing allows for simple, non-invasive and precise measurement of changes in blood volume.

The purpose of the study is to investigate and describe changes in blood volume and fluid distribution perioperative in patients undergoing total hip arthroplasty. Furthermore, to investigate the association between changes in blood volume and incidence of orthostatic insufficiency.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients scheduled for an elective total hip arthoplasty (THA) in a standardizedfast track setting.

  • Capable of participating in CO-rebreathing measurement

  • Age ≥ 18 years

  • Able to speak and understand Danish

  • Has provided written informed consent.

Exclusion

Exclusion Criteria:

  • Intraoperative blood loss exceeding 750 mL.

  • Perioperative need for a blood transfusion.

  • Confirmed or suspected coagulopathies.

  • Factors that make CO-rebreathing measurement impossible.

  • Known orthostatic intolerance.

  • American Society of Anesthesiologists physical status (ASA) classification ≥ 4.

Study Design

Total Participants: 25
Study Start date:
March 01, 2025
Estimated Completion Date:
September 30, 2026

Connect with a study center

  • Hvidovre University Hospital

    Copenhagen, 2960
    Denmark

    Active - Recruiting

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