Phase 3 Study of MRTX849 vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-12)

Last updated: November 8, 2022
Sponsor: N/A
Overall Status: Active - Recruiting

Phase

3

Condition

Lung Cancer

Non-small Cell Lung Cancer

Treatment

N/A

Clinical Study ID

TX266594
  • Ages 18-100
  • All Genders

Study Summary

This Phase 3 study will evaluate the efficacy of the investigational agent MRTX849 versus docetaxel in patients who have been previously treated for metastatic NSCLC with a KRAS G12C mutation.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Histologically or cytologically confirmed diagnosis of NSCLC with KRAS G12C mutation.
  • Candidacy to receive treatment with docetaxel.

Exclusion

Exclusion Criteria:

  • Prior treatment with an agent targeting KRAS G12C (e.g., AMG 510).
  • Active brain metastases.

Study Design

Study Start date:
February 18, 2021
Estimated Completion Date:

Study Description

Connect with a study center

  • Mirati Research Site

    St. Leonards, New South Wales 2065
    Australia

    Active - Recruiting

  • Mirati Research Site

    Woolloongabba, Queensland 4102
    Australia

    Active - Recruiting

  • Mirati Research Site

    Bedford Park, South Australia 5042
    Australia

    Active - Recruiting

  • Mirati Research Site

    Salzburg, Salzburg 5020
    Austria

    Active - Recruiting

  • Mirati Research Site

    Brussels, Bruxelles-Capitale 1090
    Belgium

    Active - Recruiting

  • Mirati Research Site

    Charleroi, Hainaut 6000
    Belgium

    Active - Recruiting

  • Mirati Research Site

    Yvoir, Namur B-5530
    Belgium

    Active - Recruiting

  • Mirati Research Site

    Gent, Oost-Vlaaderen 9000
    Belgium

    Active - Recruiting

  • Mirati Research Site

    Roeselare, West-Vlaanderen 8800
    Belgium

    Active - Recruiting

  • Mirati Research Site

    Strasbourg Cedex, Alsace 67200
    France

    Active - Recruiting

  • Mirati Research Site

    Caen Cedex 5, Basse-Normandie 14076
    France

    Active - Recruiting

  • Mirati Research Site

    Caen cedex 9, Basse-Normandie 14033
    France

    Active - Recruiting

  • Mirati Research Site

    Dijon cedex, Bourgogne 21079
    France

    Active - Recruiting

  • Mirati Research Site

    Brest, Bretagne 29609
    France

    Active - Recruiting

  • Mirati Research Site

    Quimper, Cornouaille 29107
    France

    Active - Recruiting

  • Mirati Research Site

    Creteil, Creteil 94010
    France

    Active - Recruiting

  • Mirati Research Site

    Quimper, Finistère 29107
    France

    Active - Recruiting

  • Mirati Research Site

    Mulhouse, Grand Est 68100
    France

    Active - Recruiting

  • Mirati Research Site

    Limoges cedex, Limousin 87000
    France

    Active - Recruiting

  • Mirati Research Site

    Saint Herblain, Loire-Atlantique 44805
    France

    Active - Recruiting

  • Mirati Research Site

    Marseille, Provence Alpes Cote D-Azure 13009
    France

    Active - Recruiting

  • Mirati Research Site

    Gleize, Rhône 69400
    France

    Active - Recruiting

  • Mirati Research Site

    Villejuif, Val-de-Marne 94805
    France

    Active - Recruiting

  • Mirati Research Site

    Bron, 69677
    France

    Active - Recruiting

  • Mirati Research Site

    Montpellier, 34295
    France

    Active - Recruiting

  • Mirati Research Site

    Kassel, Hessen 34125
    Germany

    Active - Recruiting

  • Mirati Research Site

    Oldenburg, Niedersachsen 26121
    Germany

    Active - Recruiting

  • Mirati Research Site

    Lübeck, Schleswig-Holstein 23538
    Germany

    Active - Recruiting

  • Mirati Research Site

    Athens, Attica 11527
    Greece

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  • Mirati Research Site

    Thessaloniki, Central Macedonia 57010
    Greece

    Active - Recruiting

  • Mirati Research Site

    Heraklion, Crete 71110
    Greece

    Active - Recruiting

  • Mirati Research Site

    Nea Kifisia, Kalyftaki 145 64
    Greece

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  • Mirati Research Site

    Neo Faliro, Piraeus 18547
    Greece

    Active - Recruiting

  • Mirati Research Site

    Thessaloniki, Pylaia 57001
    Greece

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  • Mirati Research Site

    Larissa, Thessaly 41110
    Greece

    Active - Recruiting

  • Mirati Research Site

    Shatin, Hong Kong
    Hong Kong

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  • Mirati Research Site

    Kowloon, Kowloon
    Hong Kong

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  • Mirati Research Site

    Budapest, Budapest 1083
    Hungary

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  • Mirati Research Site

    Budapest, Budapest 1122
    Hungary

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  • Mirati Research Site

    Gyöngyös, Heves 3233
    Hungary

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  • Mirati Research Site

    Törökbálint, Törökbálint 2045
    Hungary

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  • Mirati Research Site

    Dublin, Dublin 9
    Ireland

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  • Mirati Research Site

    Galway, Galway H91 YR71
    Ireland

    Active - Recruiting

  • Mirati Research Site

    Alessandria, Alessandria 15121
    Italy

    Active - Recruiting

  • Mirati Research Site

    Meldola, Forlì-Cesena 47014
    Italy

    Active - Recruiting

  • Mirati Research Site

    Milano, Milan 20133
    Italy

    Active - Recruiting

  • Mirati Research Site

    Napoli, Naples 80131
    Italy

    Active - Recruiting

  • Mirati Research Site

    Parma, Parma 43126
    Italy

    Active - Recruiting

  • Mirati Research Site

    Candiolo, Torino 10060
    Italy

    Active - Recruiting

  • Mirati Research Site

    Milano, 20141
    Italy

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  • Mirati Research Site

    Busan, Busan 602702
    Korea, Republic of

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  • Mirati Research Site

    Cheongju-si, Chungcheongbugdo 28644
    Korea, Republic of

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  • Mirati Research Site

    Daegu, Daegu Gwang'yeogsi 41404
    Korea, Republic of

    Active - Recruiting

  • Mirati Research Site

    Seongnam-si, Gyeonggido (Kyonggi-do) 13620
    Korea, Republic of

    Active - Recruiting

  • Mirati Research Site

    Suwon-si, Gyeonggido [Kyonggi-do 16499
    Korea, Republic of

    Active - Recruiting

  • Mirati Research Site

    Icheon, Incheon Gwang'yeogsi (Inch'on-Kwangyokshi) 21565
    Korea, Republic of

    Active - Recruiting

  • Mirati Research Site

    Incheon, Incheon Gwang'yeogsi (Inch'on-Kwangyokshi) 22332
    Korea, Republic of

    Active - Recruiting

  • Mirati Research Site

    Hwasun-gun, Jeonranamdo 58128
    Korea, Republic of

    Active - Recruiting

  • Mirati Research Site

    Seoul, Seoul Teugbyeolsi 06591
    Korea, Republic of

    Active - Recruiting

  • Mirati Research Site

    Seoul, Seoul Teugbyeolsi (Seoul-T'ukpyolshi) 02841
    Korea, Republic of

    Active - Recruiting

  • Mirati Research Site

    Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi] 05505
    Korea, Republic of

    Active - Recruiting

  • Mirati Research Site

    Seoul, 5080
    Korea, Republic of

    Active - Recruiting

  • Mirati Research Site

    Otwock, Mazowieckie 05-400
    Poland

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  • Mirati Research Site

    Warszawa, Mazowieckie 02-781
    Poland

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  • Mirati Research Site

    Torun, Torun 87-100
    Poland

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  • Mirati Research Site

    Lublin, 20-D64
    Poland

    Active - Recruiting

  • Mirati Research Site

    Rzeszow, 35-021
    Poland

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  • Mirati Research Site

    Skorzewo, 60-185
    Poland

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  • Mirati Research Site

    Braga, Braga 4710-243
    Portugal

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  • Mirati Research Site

    Guimarães, Guimarães 4835-044
    Portugal

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  • Mirati Research Site

    Lisboa, Lisbon 1998-018
    Portugal

    Active - Recruiting

  • Mirati Research Site

    Porto, Porto 14341
    Portugal

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  • Mirati Research Site

    Porto, Porto 4099-001
    Portugal

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  • Mirati Research Site

    Chelyabinsk, Chelyabinsk 454048
    Russian Federation

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  • Mirati Research Site

    Kursk, Kurskaya Obl 305035
    Russian Federation

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  • Mirati Research Site

    Moscow, Moscow 121467
    Russian Federation

    Active - Recruiting

  • Mirati Research Site

    Nizhniy Novgorod, Nizhny Novgorod 603006
    Russian Federation

    Active - Recruiting

  • Mirati Research Site

    Saint-Petersburg, Saint-Petersburg 197376
    Russian Federation

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  • Mirati Research Site

    Saint-Petersburg, Saint-Petersburg 197022
    Russian Federation

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  • Mirati Research Site

    Izhevsk, Udmurt Republic 426009
    Russian Federation

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  • Mirati Research Site

    Moscow, 121309
    Russian Federation

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  • Mirati Research Site

    Novosibirsk, 630099
    Russian Federation

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  • Mirati Research Site

    Omsk, 644013
    Russian Federation

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  • Mirati Research Site

    Omsk, 644013
    Russian Federation

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  • Mirati Research Site

    Singapore, Singapore 308900
    Singapore

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  • Mirati Research Site

    Singapore, Singapore 217562
    Singapore

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  • Mirati Research Site

    Singapore, 258500
    Singapore

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  • Mirati Research Site

    Palma de Mallorca, Balearic Islands 07120
    Spain

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  • Mirati Research Site

    Barcelona, Barcelona 08028
    Spain

    Active - Recruiting

  • Mirati Research Site

    Barcelona, Barcelona 8035
    Spain

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  • Mirati Research Site

    Barcelona, Barcelona 08036
    Spain

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  • Mirati Research Site

    Santander, Cantabria 39008
    Spain

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  • Mirati Research Site

    Granada, Granada 18014
    Spain

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  • Mirati Research Site

    A Coruña, La Coruña 15006
    Spain

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  • Mirati Research Site

    Madrid, Madrid 28034
    Spain

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  • Mirati Research Site

    Madrid, Madrid 28027
    Spain

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  • Mirati Research Site

    Madrid, Madrid 28040
    Spain

    Active - Recruiting

  • Mirati Research Site

    Madrid, Madrid 28041
    Spain

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  • Mirati Research Site

    Madrid, Madrid 28006
    Spain

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  • Mirati Research Site

    Malaga, Malaga 29011
    Spain

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  • Mirati Research Site

    Valencia, Valencia 46026
    Spain

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  • Mirati Research Site

    Zaragoza, Zaragoza 50009
    Spain

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  • Mirati Research Site

    Basel, Basel-Stadt 4031
    Switzerland

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  • Mirati Research Site

    Thun, Thun 3600
    Switzerland

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  • Mirati Research Site

    Winterthur, Zürich 8401
    Switzerland

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  • Mirati Research Site

    Leicester, England LE1 5WW
    United Kingdom

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  • Mirati Research Site

    Manchester, England M20 4BX
    United Kingdom

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  • Mirati Research Site

    Edinburgh, Scotland EHR 2XR
    United Kingdom

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  • Mirati Research Site

    Glasgow, Scotland G12 0YN
    United Kingdom

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  • Mirati Research Site

    Duarte, California 91010
    United States

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  • Mirati Research Site

    Santa Rosa, California 95403
    United States

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  • Mirati Research Site

    Whittier, California 90603
    United States

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  • Mirati Research Site

    Grand Junction, Colorado 81502
    United States

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  • Mirati Research Site

    Lafayette, Colorado 80026
    United States

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  • Mirati Research Site

    Lone Tree, Colorado 80124
    United States

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  • Mirati Research Site

    Fort Lauderdale, Florida 33308
    United States

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  • Mirati Research Site

    Jacksonville, Florida 32204
    United States

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  • Mirati Research Site

    Miami Beach, Florida 33140
    United States

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  • Mirati Research Site

    Orlando, Florida 32806
    United States

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  • Mirati Research Site

    Plantation, Florida 33322
    United States

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  • Mirati Research Site

    St. Augustine, Florida 32086
    United States

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  • Mirati Research Site

    Athens, Georgia 30607
    United States

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  • Mirati Research Site

    Marietta, Georgia 30060
    United States

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  • Mirati Research Site

    Arlington Heights, Illinois 60005
    United States

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  • Mirati Research Site

    Chicago, Illinois 60612
    United States

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  • Mirati Research Site

    Chicago, Illinois 60637
    United States

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  • Mirati Research Site

    Goshen, Indiana 46526
    United States

    Active - Recruiting

  • Mirati Research Site

    Indianapolis, Indiana 46237
    United States

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  • Mirati Research Site

    Westwood, Kansas 66205
    United States

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  • Mirati Research Site

    Wichita, Kansas 67214
    United States

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  • Mirati Research Site

    Lexington, Kentucky 40503
    United States

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  • Mirati Research Site

    New Orleans, Louisiana 70112
    United States

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  • Mirati Research Site

    Scarborough, Maine 04074
    United States

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  • Mirati Research Site

    Frederick, Maryland 21702
    United States

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  • Mirati Research Site

    Bolivar, Missouri 65613
    United States

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  • Mirati Research Site

    Billings, Montana 59102
    United States

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  • Mirati Research Site

    Billings, Montana 59102
    United States

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  • Mirati Research Site

    East Brunswick, New Jersey 08816
    United States

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  • Mirati Research Site

    Teaneck, New Jersey 07666
    United States

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  • Mirati Research Site

    Syracuse, New York 13210-2306
    United States

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  • Mirati Research Site

    Cleveland, Ohio 44106
    United States

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  • Mirati Research Site

    Kettering, Ohio 45429
    United States

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  • Mirati Research Site

    Salem, Oregon 97301
    United States

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  • Mirati Research Site

    Providence, Rhode Island 02903
    United States

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  • Mirati Research Site

    Easley, South Carolina 29640
    United States

    Active - Recruiting

  • Mirati Research Site

    Arlington, Texas 76012
    United States

    Active - Recruiting

  • Mirati Research Site

    Charlottesville, Virginia 22903
    United States

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  • Mirati Research Site

    Strasbourg Cedex, Alsace 67091

    Active - Recruiting

  • Mirati Research Site

    Löwenstein, Baden-Württemberg 74245

    Active - Recruiting

  • Mirati Research Site

    Gauting, Bayern 82131

    Active - Recruiting

  • Mirati Research Site

    München, Bayern 81925

    Active - Recruiting

  • Mirati Research Site

    Busan, Busan Gwang'yeogsi [Pusan-Kwangyokshi] 48108

    Active - Recruiting

  • Mirati Research Site

    Long Beach, California 90813

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  • Mirati Research Site

    Klagenfurt, Carinthia 9020

    Active - Recruiting

  • Mirati Research Site

    Thessaloniki, Central Macedonia 57001

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  • Mirati Research Site

    Coimbra, Coimbra 3000-075

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  • Mirati Research Site

    Dublin, Dublin D04 Y8V0

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  • Mirati Research Site

    Ronse, East Flanders 9600

    Active - Recruiting

  • Mirati Research Site

    Seongnam-si, Gyeonggi-Do 13496

    Active - Recruiting

  • Mirati Research Site

    Daegu, Gyeongsangbugdo Kyongsangbuk-do 42601

    Active - Recruiting

  • Mirati Research Site

    Gießen, Hessen 35292

    Active - Recruiting

  • Mirati Research Site

    Offenbach, Hessen 63069

    Active - Recruiting

  • Mirati Research Site

    Hořovice, Hořovice 268 31

    Active - Recruiting

  • Mirati Research Site

    Tours Cedex 9, Indre-et-Loire 37044

    Active - Recruiting

  • Mirati Research Site

    Lisbon, Lisboa 1400-038

    Active - Recruiting

  • Mirati Research Site

    Lublin, Lubelskie 20-093

    Active - Recruiting

  • Mirati Research Site

    Lugo, Lugo 27003

    Active - Recruiting

  • Mirati Research Site

    Madrid, Madrid 28220

    Active - Recruiting

  • Mirati Research Site

    Milan, Milan 20132

    Active - Recruiting

  • Mirati Research Site

    Napoli, Napoli 80138

    Active - Recruiting

  • Mirati Research Site

    Bonn, Nordrhein-Westfalen 53127

    Active - Recruiting

  • Mirati Research Site

    Essen, Nordrhein-Westfalen 45136

    Active - Recruiting

  • Mirati Research Site

    Olomouc, Olomouc 779 00

    Active - Recruiting

  • Mirati Research Site

    Perugia, Perugia 06132

    Active - Recruiting

  • Mirati Research Site

    Budapest, Pest 1121

    Active - Recruiting

  • Mirati Research Site

    Praha 2, Prague 128 08

    Active - Recruiting

  • Mirati Research Site

    Nice Cedex 2, Provence Alpes Cote D-Azur 06189

    Active - Recruiting

  • Mirati Research Site

    Douglas, Queensland 4814

    Active - Recruiting

  • Mirati Research Site

    La Tronche, Rhone-Alpes 38700

    Active - Recruiting

  • Mirati Research Site

    Halle (Saale), Sachsen-Anhalt 06120

    Active - Recruiting

  • Mirati Research Site

    Großhansdorf, Schleswig-Holstein 22927

    Active - Recruiting

  • Mirati Research Site

    Volos, Thessaly 38333

    Active - Recruiting

  • Mirati Research Site

    Jena, Thuringen 07747

    Active - Recruiting

  • Mirati Research Site

    València, València 46018

    Active - Recruiting

  • Mirati Research Site

    Vila Nova de Gaia, Vila Nova de Gaia 4434-502

    Active - Recruiting

  • Mirati Research Site

    Alicante, 03010

    Active - Recruiting

  • Mirati Research Site

    Avellino, 83100

    Active - Recruiting

  • Mirati Research Site

    Avellino, 83100

    Active - Recruiting

  • Mirati Research Site

    Bad Berka, 99437

    Active - Recruiting

  • Mirati Research Site

    Bad Berka, 99437

    Active - Recruiting

  • Mirati Research Site

    Badalona, 08916

    Active - Recruiting

  • Mirati Research Site

    Barcelona, 08003

    Active - Recruiting

  • Mirati Research Site

    Bari, 70124

    Active - Recruiting

  • Mirati Research Site

    Catania, 95100

    Active - Recruiting

  • Mirati Research Site

    Catania, 95125

    Active - Recruiting

  • Mirati Research Site

    Cordoba, 14004

    Active - Recruiting

  • Mirati Research Site

    Dublin, D24 NR04

    Active - Recruiting

  • Mirati Research Site

    Dublin, D08 NHY1

    Active - Recruiting

  • Mirati Research Site

    Dublin, D24 NR04

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  • Mirati Research Site

    Genova, 16100

    Active - Recruiting

  • Mirati Research Site

    Girona, 17007

    Active - Recruiting

  • Mirati Research Site

    Lecce, 73100

    Active - Recruiting

  • Mirati Research Site

    Lódzkie, 90-302

    Active - Recruiting

  • Mirati Research Site

    Porto, 4200-072

    Active - Recruiting

  • Mirati Research Site

    Prague, 180 00

    Active - Recruiting

  • Mirati Research Site

    Sevilla, 41013

    Active - Recruiting

  • Mirati Research Site

    Singapore, 188770

    Active - Recruiting

  • Mirati Research Site

    Székesfehérvár, 8000

    Active - Recruiting

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