Early Onset Alzheimer's Disease study

Last updated: March 4, 2022
Sponsor: N/A
Overall Status: Active - Recruiting

Phase

N/A

Condition

Mild Cognitive Impairment

Healthy Volunteers

Alzheimer's Disease

Treatment

N/A

Clinical Study ID

TX286255
online_AG054080-01
  • Ages 18-100
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study is looking for families who have one or more individuals with early-onset Alzheimer’s. The study is interested in the genetic factors across family members. This may help to develop methods for predicting or diagnosing early-onset Alzheimer’s.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • You are part of a family with early-onset Alzheimer’s (in other words, Alzheimer’s that was diagnosed when the individual was younger than 65). Examples of families who could be included are:
    -A family with three or more individuals affected by early-onset Alzheimer’s, and one or more cognitively normal individual over age 60.
    -A family with one or two related individuals with early-onset Alzheimer’s.
    -A family with an individual with early-onset Alzheimer’s and an individual with late-onset Alzheimer’s.
    -A family with an individual with early-onset Alzheimer’s and an individual with mild cognitive impairment.

Exclusion

Exclusion Criteria:

  • Your family does not have at least one individual with early-onset Alzheimer’s.
  • Your family members have a non-Alzheimer’s cognitive diagnosis, such as frontotemporal dementia, traumatic brain injury, or vascular brain injury.

Study Design

Study Start date:
Estimated Completion Date:

Study Description

Study schedule:
At the start of the study:
-You will have a screening telephone call.
-You will have in-person cognitive and neurological assessments.
-You will give a blood sample.

During the study:
-You will have a follow-up telephone interview every 18 months.
-You will repeat some or all of the study-start activities.

Study activities may include:
-Talking on the telephone.
-Having cognitive and neurological assessments, which may be in the form of interview-style conversations, paper-and-pencil questionnaires, computer tests, and/or other activities.
-Having a sample of blood drawn from your vein using a needle.

Treatment or experiment details:
-This study is interested in the genetic factors that influence early-onset Alzheimer’s.
-There is no experiment or treatment being tested in this study.

Additional details:
-Nuclear families (parent, child, siblings) as well as extended families (grandparental, cousins, uncle/aunt, etc.) may be eligible.
-Multiple family members must participate in the study together.

Connect with a study center

  • Online Study Center

    Virtual Location, 33146
    United States

    Active - Recruiting

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