ACP-204 in Adults With Alzheimer's Disease Psychosis

Inclusion Criteria:

• Is male or female and ≥55 and ≤95 years of age living in the community or in aninstitutionalized setting

• Meets clinical criteria for possible or probable AD based on the 2011 NationalInstitute on Aging-Alzheimer Association (NIA-AA) criteria

• Meets the revised criteria for psychosis in major or mild neurocognitive disorderestablished by the International Psychogeriatrics Association (IPA)

• Has either blood-based biomarker or documented evidence (e.g. positron emissiontomography, cerebrospinal fluid biomarker) indicating amyloid plaque deposition andneuropathologic change consistent with AD

• Has a prior magnetic resonance imaging or computed tomography scan of the brain thatis consistent with the diagnosis of AD

• Meets revised criteria for psychosis in major or mild neurocognitive disorder as perInternational Psychogeriatrics Association

• MMSE score ≥6 and ≤24

• Psychotic symptoms for at least 2 months

• Lives in a stable place of residence and there are no plans to change livingarrangements

• Has a designated study partner/caregiver

• Able to complete all study visits with a study partner/caregiver

• Must be on a stable dose of cholinesterase inhibitor or memantine, if applicable

Exclusion Criteria:

• Requires treatment with a medication prohibited by the protocol

• Is in hospice and receiving end-of-life palliative care, or has become bedridden

• Requires skilled nursing care

• Psychotic symptoms that are primarily attributable to delirium, substance abuse, ora medical or psychiatric condition other than dementia

• Known history of cerebral amyloid angiopathy, epilepsy, central nervous systemneoplasm, or unexplained syncope

• Atrial fibrillation

• Symptomatic orthostatic hypotension

• Protocol-defined exclusionary clinical laboratory findings

• Treatment with anti-tau therapy or donanemab within 2 months prior to Screening

Additional inclusion/exclusion criteria apply. Subjects will be evaluated at screening to ensure that all criteria for study participation are met.