Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)

Inclusion Criteria:

• Participants must be greater than or equal to (>=) 40 to less than or equal to (<=) 80 years of age, at the time of signing the Informed consent

• Elevated Blood Eosinophil Count (BEC)

• Moderate to severe COPD with frequent exacerbations, defined as:

• A clinically documented history of COPD as defined by the American ThoracicSociety/European Respiratory Society for at least 1 year

• A post-bronchodilator forced expiratory volume in one second (FEV1)/ forcedvital capacity (FVC) ratio of < 0.70 and a post-bronchodilator FEV1 >30 percent (%) and <= 80% predicted normal values

• A well-documented history of at least 2 moderate or 1 severe exacerbation inthe 12 months prior to screening

• COPD assessment test (CAT) score >=10 at Visit 1

• Smoking status: Current or former cigarette smokers with a history of cigarettesmoking of >=10 pack-years.

• Participants should be on optimized inhaler therapy, defined as inhaledcorticosteroid (ICS) plus Long-acting muscarinic receptor antagonist (LAMA) plusLong-acting beta2-adrenergic receptor agonist (LABA) either as multiple inhalers ora single combination inhaler for at least 6 months prior to Screening Visit 1

• Body mass index (BMI) >=16 kilogram per square meter (kg/m^2)

• Male and eligible female participants

Exclusion Criteria:

The following subjects are excluded:

• Participants with a current or prior physician diagnosis of asthma

• Other clinically significant lung disease: The Investigator must judge that COPD isthe primary diagnosis accounting for the clinical manifestations of the lung disease

• Participants with pneumonia, COPD exacerbation, or lower respiratory tract infectionwithin the 4 weeks prior to Screening Visit 1

• Lung resection: Participants with a history of or plan for lung volume reductionsurgery / endobronchial valve procedure.

• Pulmonary rehabilitation: Participants in the acute phase of a pulmonaryrehabilitation program within 4 weeks prior to Screening Visit 1

• Continuous oxygen: Participants requiring oxygen supplementation for more than 12hours per day

• Cor pulmonale - resulting in right heart failure, severe pulmonary hypertension

• Chronic hypercapnia requiring Non-invasive positive pressure ventilation (NIPPV) use (including Bi-Level Positive Airway Pressure [BiPAP] or Continuous Positive AirwayPressure [CPAP])

• Unstable cardiovascular disease or arrhythmia

• Parasitic Infection: Participants with a known, pre-existing parasitic infectionwithin 6 months of Screening (Visit 1)