Evaluation of Obicetrapib on Antioxidant Levels in Plasma and HDL Particles of Healthy Volunteers

Last updated: October 15, 2025
Sponsor: NewAmsterdam Pharma
Overall Status: Active - Recruiting

Phase

2

Condition

N/A

Treatment

Obicetrapib 10mg

Placebo

Clinical Study ID

NCT06982508
TA-8995-207
  • Ages 18-75
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The goal of this clinical trial is to learn if Obicetrapib works to change antioxidant levels in HDL and plasma, as well as retinal tissue. The main questions it aims to answer are:

Do Obicetrapib effect absorption of antioxidants in a person's blood or their eye tissue? Researchers will compare Obicetrapib to a placebo (a look-alike substance that contains no drug) to see if Obicetrapib helps improve a person's ability to absorb antioxidants.

Participants will:

Take Obicetrapib or a placebo every day for 4 months Visit the clinic once every 8 weeks for checkups and tests Have their blood taken and their eyes checked to measure antioxidant levels

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Visual acuity > 20/60 in both eyes with or without corrective lenses

Exclusion

Exclusion Criteria:

  • Type 2 diabetes

  • Active liver disease

  • Any clinically significant macular pathology

Study Design

Total Participants: 100
Treatment Group(s): 2
Primary Treatment: Obicetrapib 10mg
Phase: 2
Study Start date:
September 09, 2025
Estimated Completion Date:
December 31, 2026

Connect with a study center

  • Excellence Medical Research

    Miami Gardens 4164167, Florida 4155751 33169
    United States

    Active - Recruiting

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