Phase
Condition
Leukemia
Bone Neoplasm
Cancer/tumors
Treatment
Mezigdomide
Dexamethasone
Elranatamab
Clinical Study ID
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Age ≥18 with history of relapsed and refractory multiple myeloma (RRMM) treated with 2 to 4 prior lines of anti-myeloma therapy (Phase 1) or 1 to 3 prior lines ofanti-myeloma therapy (Phase 2).
Measurable MM by local laboratory.
Eastern Cooperative Oncology Group performance status (ECOG PS) of 0 to 1.
Adherence to contraception requirements.
Exclusion
Exclusion Criteria:
Prior treatment with mezigdomide.
Prior treatment with T cell engaging or T cell engager (TCE).
Prior treatment with B cell-maturation antigen (BCMA)-targeting therapy, with theexception of participants who have received autologous BCMA-targeted CART-celltherapy> 6 months from the start of study therapy
Other protocol-defined Inclusion/Exclusion criteria apply.
Study Design
Connect with a study center
Local Institution - 0032
Calgary, Alberta T2N 5G2
CanadaSite Not Available
Arthur J E Child Comprehensive Cancer Centre
Calgary 5913490, Alberta 5883102 T2N 5G2
CanadaActive - Recruiting
Local Institution - 0032
Calgary 5913490, Alberta 5883102 T2N 5G2
CanadaSite Not Available
Local Institution - 0026
Vancouver, British Columbia V5Z 4E6
CanadaSite Not Available
Local Institution - 0026
Vancouver 6173331, British Columbia 5909050 V5Z 4E6
CanadaSite Not Available
Local Institution - 0027
Halifax, Nova Scotia B3H 2Y9
CanadaSite Not Available
Local Institution - 0027
Halifax 6324729, Nova Scotia 6091530 B3H 2Y9
CanadaSite Not Available
Local Institution - 0024
Toronto, Ontario M5G 2M9
CanadaSite Not Available
Princess Margaret Cancer Centre
Toronto 6167865, Ontario 6093943 M5G 2M9
CanadaActive - Recruiting
Local Institution - 0030
Suzhou, Jiangsu 215006
ChinaSite Not Available
Local Institution - 0030
Suzhou 1886760, Jiangsu 1806260 215006
ChinaSite Not Available
Local Institution - 0031
Shanghai, Shanghai 200434
ChinaSite Not Available
Local Institution - 0031
Shanghai 1796236, Shanghai Municipality 1796231 200434
ChinaSite Not Available
Local Institution - 0015
Dresden, 01307
GermanySite Not Available
Local Institution - 0015
Dresden 2935022, 01307
GermanySite Not Available
Universitaetsklinikum Carl Gustav Carus Dresden
Dresden 2935022, 01307
GermanyActive - Recruiting
Local Institution - 0013
Hamburg, 20246
GermanySite Not Available
Local Institution - 0013
Hamburg 2911298, 20246
GermanySite Not Available
Universitaetsklinikum Hamburg-Eppendorf
Hamburg 2911298, 20246
GermanyActive - Recruiting
Local Institution - 0014
Heidelberg, D-69120
GermanySite Not Available
Local Institution - 0014
Heidelberg 2907911, D-69120
GermanySite Not Available
Universitaetsklinikum Heidelberg
Heidelberg 2907911, 69120
GermanyActive - Recruiting
Local Institution - 0011
Athens, Attikí 106 76
GreeceSite Not Available
Local Institution - 0012
Athens, Attikí 115 28
GreeceSite Not Available
Alexandra General Hospital of Athens
Athens 264371, Attikí 115 28
GreeceActive - Recruiting
Evangelismos General Hospital of Athens
Athens 264371, Attikí 106 76
GreeceActive - Recruiting
Local Institution - 0011
Athens 264371, Attikí 106 76
GreeceSite Not Available
Local Institution - 0012
Athens 264371, Attikí 115 28
GreeceSite Not Available
Local Institution - 0017
Trondheim, Sør-Trøndelag 7030
NorwaySite Not Available
Local Institution - 0017
Trondheim 3133880, Sør-Trøndelag 7030
NorwaySite Not Available
St. Olavs Hospital
Trondheim 3133880, Sør-Trøndelag 7030
NorwayActive - Recruiting
Local Institution - 0019
Oslo, 0450
NorwaySite Not Available
Local Institution - 0019
Oslo 3143244, 0450
NorwaySite Not Available
Sykehusapoteket Ull
Oslo 3143244, 0450
NorwayActive - Recruiting
Local Institution - 0021
Santander, Cantabria 39008
SpainSite Not Available
Hospital Universitario Marqués de Valdecilla
Santander 3109718, Cantabria 3336898 39008
SpainActive - Recruiting
Local Institution - 0021
Santander 3109718, Cantabria 3336898 39008
SpainSite Not Available
Local Institution - 0022
Salamanca, 37007
SpainSite Not Available
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca
Salamanca 3111108, 37007
SpainActive - Recruiting
Local Institution - 0022
Salamanca 3111108, 37007
SpainSite Not Available
Local Institution - 0016
London, England W1T 7HA
United KingdomSite Not Available
Local Institution - 0016
London 2643743, England 6269131 W1T 7HA
United KingdomSite Not Available
University College London Hospital
London 2643743, England 6269131 W1T 7HA
United KingdomActive - Recruiting
Local Institution - 0018
London, Sutton SM2 5PT
United KingdomSite Not Available
Local Institution - 0018
London 2643743, Sutton SM2 5PT
United KingdomSite Not Available
Royal Marsden Hospital (Sutton)
London 2643743, Sutton SM2 5PT
United KingdomActive - Recruiting
Local Institution - 0020
Manchester, M20 4BX
United KingdomSite Not Available
Local Institution - 0020
Manchester 2643123, M20 4BX
United KingdomSite Not Available
The Christie NHS Foundation Trust
Manchester 2643123, M20 4BX
United KingdomActive - Recruiting
Local Institution - 0001
Birmingham, Alabama 35294-3300
United StatesSite Not Available
Local Institution - 0001
Birmingham 4049979, Alabama 4829764 35294-3300
United StatesSite Not Available
University of Alabama at Birmingham
Birmingham 4049979, Alabama 4829764 35294-3300
United StatesActive - Recruiting
Local Institution - 0029
New Haven, Connecticut 06510
United StatesSite Not Available
Local Institution - 0029
New Haven 4839366, Connecticut 4831725 06510
United StatesSite Not Available
Yale New Haven Hospital-Smilow Cancer Center
New Haven 4839366, Connecticut 4831725 06510
United StatesActive - Recruiting
Local Institution - 0028
Hackensack, New Jersey 07601
United StatesSite Not Available
Hackensack University Medical Center
Hackensack 5098706, New Jersey 5101760 07601
United StatesActive - Recruiting
Local Institution - 0028
Hackensack 5098706, New Jersey 5101760 07601
United StatesSite Not Available
Local Institution - 0005
Houston, Texas 77030
United StatesSite Not Available
University of Texas MD Anderson Cancer Center
Houston 4699066, Texas 4736286 77030
United StatesActive - Recruiting
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