Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

Inclusion Criteria:

• Is 18 years or older for patients with established cardiovascular disease (CVD)

• Is 55 years or older for patients with high risk for CVD

• Has established CVD (defined as coronary, cerebrovascular, or peripheral arterydisease) or high risk for CVD

• Has treated hypertension on stable therapy with at least 2 standard of careantihypertensive medications, one of which must be a thiazide, thiazide-like, orloop diuretic

Exclusion Criteria:

• Has known history of secondary hypertension

• Has symptomatic orthostatic hypotension

• Has alanine aminotransferase (ALT) or aspartate aminotransferase (AST) >3×upperlimit of normal (ULN)

• Has total serum bilirubin >1.5×ULN

• Has international normalized ratio (INR) >1.5

• Has serum potassium >4.8 mEq/L

• Has estimated glomerular filtration rate (eGFR) <30 mL/min/1.73m^2