Efficacy and Safety of Orforglipron in Participants With Peripheral Artery Disease

Inclusion Criteria:

• Have symptomatic PAD with intermittent claudication of Fontaine Stage II

• Have an Ankle Brachial Index (ABI) of 0.9 or less

Exclusion Criteria:

• Have a body mass index (BMI) less than 23 kilogram per square meter (kg/m2)

• Have Hemoglobin A1c (HbA1c) greater than 10%

• Have walking ability limited by conditions other than PAD

• Have a planned lower limb surgery or any other surgery affecting walking ability

• Had peripheral revascularization procedure within 90 days prior to the day ofscreening or planning to undergo peripheral revascularization during the clinicaltrial

• Had stroke, transient ischemic attack, myocardial infarction, coronary or carotidrevascularization, or hospitalization for unstable angina pectoris within 60 daysprior to screening

• Have heart failure presently classified as being in New York Heart Association classIII - IV