Effect of Full-House ESS With Nasopharyngeal Lymphoid Tissue Ablation on Nasal Polyps

Last updated: November 17, 2025
Sponsor: Tongji Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Nasal Obstruction

Rhinitis, Allergic, Perennial

Polyps

Treatment

Full-House Endoscopic Sinus Surgery

Nasopharyngeal Lymphoid Tissue Ablation

Clinical Study ID

NCT07245329
TJ-IRB202506055
  • Ages 18-65
  • All Genders

Study Summary

This study is designed to evaluate whether the addition of nasopharyngeal lymphoid tissue ablation to full-house endoscopic sinus surgery (ESS) provides superior control of nasal mucosa inflammation compared to full-house ESS alone in patients with nasal polyps. Thirty-two adult participants will be randomly assigned to undergo either full-house ESS only or full-house ESS combined with nasopharyngeal lymphoid tissue ablation. The primary outcome will be assessed through changes in inflammatory cell profiles at 1, 3, and 6 months postoperatively. Secondary outcomes include inflammatory cytokine levels, symptom scores, endoscopic findings, polyp recurrence rates, and safety measures.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Aged 18-65 years

  • Diagnosed with CRSwNP according to EPOS criteria

  • Blood eosinophil count > 0.3 × 10⁹/L

Exclusion

Exclusion Criteria:

  • Pregnant or lactating women.

  • Cystic fibrosis

  • primary ciliary dyskinesia

  • fungal ball rhinosinusitis

  • systemic vasculitis or granulomatous disease

  • malignancy

  • immunodeficiency.

  • Subjects with an upper-respiratory-tract infection within the past 4 weeks.

  • Clinically significant metabolic, cardiovascular, immune, neurologic, hematologic,gastrointestinal, cerebrovascular, or respiratory disorders, or any condition that,in the investigator's opinion, could interfere with outcome assessment or compromisepatient safety.

  • Currently participating in another clinical trial or having participated in onewithin 30 days, or staff directly involved in this study.

Study Design

Total Participants: 32
Treatment Group(s): 2
Primary Treatment: Full-House Endoscopic Sinus Surgery
Phase:
Study Start date:
July 01, 2025
Estimated Completion Date:
August 01, 2026

Connect with a study center

  • Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology

    Wuhan 1791247, Hubei 1806949 430030
    China

    Active - Recruiting

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