A Comparison of Valganciclovir and Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes

Last updated: May 15, 2017
Sponsor: Hoffmann-La Roche
Overall Status: Completed

Phase

3

Condition

Hiv Infections

Eye Disorders/infections

Cytomegalovirus Infections

Treatment

N/A

Clinical Study ID

NCT00002377
WV15376
  • Ages > 14
  • All Genders

Study Summary

To investigate the efficacy and safety of RS-79070 when used as induction therapy in patients with newly diagnosed peripheral retinitis. To assess the effects of induction and maintenance level dosing of RS-79070 on CMV viral load, estimated by plasma CMV PCR. To assess the pharmacokinetics of ganciclovir following administration of RS-79070 in the target population.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Documented AIDS diagnosis

  • Newly diagnosed peripheral CMV retinitis

  • More than 3 weeks of previous therapy for CMV retinitis

Study Design

Study Start date:
January 01, 1997
Estimated Completion Date:
December 31, 2002

Connect with a study center

  • St Pauls Hosp

    Vancouver, British Columbia
    Canada

    Site Not Available

  • The Toronto Hosp / Dept of Infectious Disease

    Toronto, Ontario
    Canada

    Site Not Available

  • Montreal Chest Institute

    Montreal, Quebec
    Canada

    Site Not Available

  • Royal Victoria Hosp

    Montreal, Quebec
    Canada

    Site Not Available

  • Univ of California / Irvine

    Irvine, California 92697
    United States

    Site Not Available

  • Univ of California / San Diego / Dept of Pediatrics

    La Jolla, California 92093
    United States

    Site Not Available

  • Univ of California / San Diego Treatment Ctr

    San Diego, California 92103
    United States

    Site Not Available

  • Davies Med Ctr / Institute for HIV Research

    San Francisco, California 94114
    United States

    Site Not Available

  • Kaiser Permanente Med Ctr

    San Francisco, California 94115
    United States

    Site Not Available

  • QUEST Clinical Research

    San Francisco, California 94115
    United States

    Site Not Available

  • Dr Alan Palestine

    Washington, District of Columbia 20006
    United States

    Site Not Available

  • Dr Alan Palestine

    Washington, D.C., District of Columbia 20006
    United States

    Site Not Available

  • Univ of Miami School of Medicine

    Miami, Florida 33136
    United States

    Site Not Available

  • Emory Eye Clinic

    Atlanta, Georgia 30322
    United States

    Site Not Available

  • New England Med Ctr

    Boston, Massachusetts 02111
    United States

    Site Not Available

  • New York Hosp - Cornell Med Ctr

    New York, New York 10021
    United States

    Site Not Available

  • New York Univ Med Ctr

    New York, New York 10016
    United States

    Site Not Available

  • St Luke's - Roosevelt Hosp Ctr / Div of Infect Dis

    New York, New York 10019
    United States

    Site Not Available

  • Duke Univ Eye Ctr

    Durham, North Carolina 27710
    United States

    Site Not Available

  • Austin Infectious Disease Consultants

    Austin, Texas 78705
    United States

    Site Not Available

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