S9921, Hormone Therapy With or Without Mitoxantrone and Prednisone in Patients Who Have Undergone Radical Prostatectomy for Prostate Cancer

Last updated: December 5, 2022
Sponsor: Southwest Oncology Group
Overall Status: Completed

Phase

3

Condition

Prostate Cancer, Early, Recurrent

Urologic Cancer

Prostate Cancer

Treatment

bicalutamide

prednisone

goserelin

Clinical Study ID

NCT00004124
CDR0000067352
CALGB-99904
U10CA032102
S9921
  • Ages 18-120
  • Male

Study Summary

RATIONALE: Hormones can stimulate the production of prostate cancer cells. Hormone therapy may fight prostate cancer by reducing the production of androgens. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether hormone therapy plus mitoxantrone and prednisone is more effective than hormone therapy alone for prostate cancer.

PURPOSE: This randomized phase III trial is studying hormone therapy, mitoxantrone, and prednisone to see how well they work compared to hormone therapy alone in treating patients who have undergone radical prostatectomy for prostate cancer.

Eligibility Criteria

Inclusion

DISEASE CHARACTERISTICS:

  • Histologically confirmed stage T1-T3 adenocarcinoma of the prostate before radical prostatectomy and lymph node dissection

  • Must have undergone prostatectomy within the past 120 days

  • Must meet at least 1 of the following pathologic criteria:

  • Gleason sum at least 8

  • pT3b (seminal vesicle), pT4, or N1

  • Gleason sum of 7 and positive margin

  • Preoperative PSA greater than 15 ng/mL, Gleason score greater than 7, or PSA level greater than 10 ng/mL and Gleason score greater than 6

  • Must have an undetectable PSA (no greater than 0.2 ng/mL) documented after surgery or prior to adjuvant hormonal therapy (for patients initiating adjuvant hormonal therapy prior to study)

  • No evidence of metastatic disease on bone scan if PSA is 20 ng/mL or greater at clinical diagnosis

  • No distant metastatic disease

PATIENT CHARACTERISTICS:

Performance status:

  • SWOG 0-1

Life expectancy:

  • Not specified

Hematopoietic:

  • Not specified

Hepatic:

  • Not specified

Renal:

  • Not specified

Cardiovascular:

  • No uncontrolled congestive heart failure

  • If history of cardiac disease, LVEF at least 50% by MUGA scan or 2-D echocardiogram

Other:

  • No HIV positivity

  • No other prior malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer or stage I or II cancer that is currently in complete remission

PRIOR CONCURRENT THERAPY:

Biologic therapy:

  • Not specified

Chemotherapy:

  • Not specified

Endocrine therapy:

  • Prior neoadjuvant hormonal therapy of no more than 4 months duration before radical prostatectomy allowed

  • Other concurrent adjuvant hormonal therapy allowed if initiated prior to study

  • Concurrent low-dose megestrol (less than 40 mg/day) for hot flashes allowed

Radiotherapy:

  • No prior radiotherapy

  • No concurrent whole pelvis irradiation

  • Concurrent radiotherapy allowed at the discretion of the physician

Surgery:

  • See Disease Characteristics

  • See Endocrine therapy

  • Recovered from prior surgery

Other:

  • No other prior or concurrent therapy for adenocarcinoma of the prostate

Study Design

Total Participants: 983
Treatment Group(s): 4
Primary Treatment: bicalutamide
Phase: 3
Study Start date:
October 15, 1999
Estimated Completion Date:
May 01, 2018

Study Description

OBJECTIVES:

  • Compare the overall and disease-free survival of patients with high-risk adenocarcinoma of the prostate treated with adjuvant androgen deprivation therapy with or without mitoxantrone and prednisone after radical prostatectomy.

  • Compare the qualitative and quantitative toxic effects of these regimens in this patient population.

  • Compare the prostate-specific antigen (PSA) progression-free survival rate in patient treated with these regimens.

  • Determine whether PSA progression is a surrogate endpoint for survival or disease-free survival in this patient population.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to surgical extent of disease (organ confined vs not organ confined, but N0 vs N1), Gleason's sum (less than 7 vs 7 vs greater than 7), and planned radiotherapy (yes vs no). Patients are randomized to one of two treatment arms.

  • Arm I:Patients receive goserelin subcutaneously once every 13 weeks (8 injections total) and oral bicalutamide once daily for 2 years in the absence of disease progression or unacceptable toxicity.

  • Arm II:Patients receive mitoxantrone IV over 30 minutes on day 1 and oral prednisone twice daily on days 1-21. Treatment repeats every 3 weeks for 6 courses in the absence of disease progression or unacceptable toxicity. Patients also receive hormonal therapy as in arm I beginning concurrently with the initiation of mitoxantrone and prednisone.

Patients may undergo radiotherapy 5 days a week for 6.5-7.8 weeks beginning anytime (arm I) or after completion of chemotherapy (arm II), at the discretion of the physician, in the absence of disease progression or unacceptable toxicity.

Patients are offered the possibility to participate in biomarker research by allowing their tissue/blood to be studied.

Patients are followed every 6 months for 2 years and then annually for up to 13 years.

PROJECTED ACCRUAL: A total of 1,360 patients (680 per treatment arm) will be accrued for this study within 9.5 years.

Connect with a study center

  • Alaska Regional Hospital Cancer Center

    Anchorage, Alaska 99508
    United States

    Site Not Available

  • Providence Cancer Center

    Anchorage, Alaska 99508
    United States

    Site Not Available

  • Banner Thunderbird Medical Center

    Glendale, Arizona 85306
    United States

    Site Not Available

  • Banner Good Samaritan Medical Center

    Phoenix, Arizona 85006
    United States

    Site Not Available

  • CCOP - Western Regional, Arizona

    Phoenix, Arizona 85006
    United States

    Site Not Available

  • Arkansas Cancer Research Center at University of Arkansas for Medical Sciences

    Little Rock, Arkansas 72205
    United States

    Site Not Available

  • Highlands Oncology Group - Springdale

    Springdale, Arkansas 72764
    United States

    Site Not Available

  • Alta Bates Comprehensive Cancer Center

    Berkeley, California 94704
    United States

    Site Not Available

  • Peninsula Medical Center

    Burlingame, California 94010
    United States

    Site Not Available

  • California Cancer Care, Incorporated

    Greenbrae, California 94904
    United States

    Site Not Available

  • Marin Cancer Institute at Marin General Hospital

    Greenbrae, California 94904
    United States

    Site Not Available

  • Sutter Health - Western Division Cancer Research Group

    Greenbrae, California 94904
    United States

    Site Not Available

  • Naval Medical Center - San Diego

    San Diego, California 92134
    United States

    Site Not Available

  • California Pacific Medical Center - California Campus

    San Francisco, California 94118
    United States

    Site Not Available

  • San Francisco General Hospital Medical Center

    San Francisco, California 94110
    United States

    Site Not Available

  • UCSF Comprehensive Cancer Center

    San Francisco, California 94115
    United States

    Site Not Available

  • Veterans Affairs Medical Center - San Francisco

    San Francisco, California 94121
    United States

    Site Not Available

  • Cancer Center of Santa Barbara

    Santa Barbara, California 93105
    United States

    Site Not Available

  • Sansum Medical Clinic

    Santa Barbara, California 93105
    United States

    Site Not Available

  • Santa Barbara Hematology Oncology Medical Group at Cancer Center of Santa Barbara

    Santa Barbara, California 93105
    United States

    Site Not Available

  • Cancer Center of Santa Barbara

    Snata Barbara, California 93105
    United States

    Site Not Available

  • Santa Barbara Hematology Oncology - Solvang

    Solvang, California 93463
    United States

    Site Not Available

  • Sutter Solano Medical Center

    Vallejo, California 94589
    United States

    Site Not Available

  • Memorial Hospital

    Colorado Springs, Colorado 80909
    United States

    Site Not Available

  • North Colorado Medical Center

    Greeley, Colorado 80631
    United States

    Site Not Available

  • McKee Medical Center

    Loveland, Colorado 80539
    United States

    Site Not Available

  • Eastern Connecticut Hematology and Oncology Associates

    Norwich, Connecticut 06360
    United States

    Site Not Available

  • Carl and Dorothy Bennett Cancer Center at Stamford Hospital

    Stamford, Connecticut 06904
    United States

    Site Not Available

  • Lombardi Comprehensive Cancer Center at Georgetown University Medical Center

    Washington, District of Columbia 20007
    United States

    Site Not Available

  • Lombardi Comprehensive Cancer Center at Georgetown University Medical Center

    Washington, D.C., District of Columbia 20007
    United States

    Site Not Available

  • MBCCOP - Medical College of Georgia Cancer Center

    Augusta, Georgia 30912
    United States

    Site Not Available

  • Northeast Georgia Medical Center

    Gainesville, Georgia 30501
    United States

    Site Not Available

  • Tripler Army Medical Center

    Honolulu, Hawaii 96859
    United States

    Site Not Available

  • Saint Anthony's Hospital at Saint Anthony's Health Center

    Alton, Illinois 62002
    United States

    Site Not Available

  • Rush-Copley Cancer Care Center

    Aurora, Illinois 60507
    United States

    Site Not Available

  • Good Shepherd Hospital

    Barrington, Illinois 60010
    United States

    Site Not Available

  • Creticos Cancer Center at Advocate Illinois Masonic Medical Center

    Chicago, Illinois 60657
    United States

    Site Not Available

  • Hematology and Oncology Associates

    Chicago, Illinois 60611
    United States

    Site Not Available

  • Mercy Hospital and Medical Center

    Chicago, Illinois 60616
    United States

    Site Not Available

  • Robert H. Lurie Comprehensive Cancer Center at Northwestern University

    Chicago, Illinois 60611-3013
    United States

    Site Not Available

  • Swedish Covenant Hospital

    Chicago, Illinois 60625
    United States

    Site Not Available

  • University of Chicago Cancer Research Center

    Chicago, Illinois 60637-1470
    United States

    Site Not Available

  • University of Illinois Cancer Center

    Chicago, Illinois 60612-7243
    United States

    Site Not Available

  • Veterans Affairs Medical Center - Chicago Westside Hospital

    Chicago, Illinois 60612
    United States

    Site Not Available

  • Veterans Affairs Medical Center - Lakeside Chicago

    Chicago, Illinois 60611
    United States

    Site Not Available

  • Advocate Good Samaritan Hospital

    Downers Grove, Illinois 60515
    United States

    Site Not Available

  • Evanston Northwestern Healthcare - Evanston Hospital

    Evanston, Illinois 60201-1781
    United States

    Site Not Available

  • Veterans Affairs Medical Center - Hines

    Hines, Illinois 60141
    United States

    Site Not Available

  • Joliet Oncology-Hematology Associates, Limited - West

    Joliet, Illinois 60435
    United States

    Site Not Available

  • Midwest Center for Hematology/Oncology

    Joliet, Illinois 60432
    United States

    Site Not Available

  • La Grange Memorial Hospital

    La Grange, Illinois 60525
    United States

    Site Not Available

  • North Shore Oncology and Hematology Associates, Limited - Libertyville

    Libertyville, Illinois 60048
    United States

    Site Not Available

  • Cardinal Bernardin Cancer Center at Loyola University Medical Center

    Maywood, Illinois 60153
    United States

    Site Not Available

  • Good Samaritan Regional Health Center

    Mount Vernon, Illinois 62864
    United States

    Site Not Available

  • Good Samaritan Regional Health Center

    Mt. Vernon, Illinois 62864
    United States

    Site Not Available

  • Cancer Care and Hematology Specialists of Chicagoland - Niles

    Niles, Illinois 60714
    United States

    Site Not Available

  • Mid-Illinois Hematology-Oncology Associates at Community Cancer Center

    Normal, Illinois 61761
    United States

    Site Not Available

  • Cancer Care Center at Advocate Lutheran Hospital

    Park Ridge, Illinois 60068
    United States

    Site Not Available

  • Hematology Oncology Associates - Skokie

    Skokie, Illinois 60076
    United States

    Site Not Available

  • Hematology/Oncology of the North Shore at Gross Point Medical Center

    Skokie, Illinois 60076
    United States

    Site Not Available

  • CCOP - Carle Cancer Center

    Urbana, Illinois 61801
    United States

    Site Not Available

  • Carle Cancer Center at Carle Foundation Hospital

    Urbana, Illinois 61801
    United States

    Site Not Available

  • Oncology/Hematology Associates of Southwest Indiana at St. Mary's Cancer Center

    Evansville, Indiana 47714
    United States

    Site Not Available

  • Indiana University Cancer Center

    Indianapolis, Indiana 46202-5289
    United States

    Site Not Available

  • Saint Anthony Memorial Health Centers

    Michigan City, Indiana 46360
    United States

    Site Not Available

  • McFarland Clinic, PC

    Ames, Iowa 50010
    United States

    Site Not Available

  • Cedar Rapids Oncology Associates

    Cedar Rapids, Iowa 52403
    United States

    Site Not Available

  • Mercy Regional Cancer Center at Mercy Medical Center

    Cedar Rapids, Iowa 52403
    United States

    Site Not Available

  • St. Luke's Hospital

    Cedar Rapids, Iowa 52402
    United States

    Site Not Available

  • Cedar Valley Medical Specialists, PC - West Ridgeway Avenue

    Waterloo, Iowa 50702
    United States

    Site Not Available

  • Covenant Cancer Treatment Center

    Waterloo, Iowa 50702
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Chanute

    Chanute, Kansas 66720
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Dodge City

    Dodge City, Kansas 67801
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - El Dorado

    El Dorado, Kansas 67042
    United States

    Site Not Available

  • Veterans Affairs Medical Center - Kansas City

    Kansas City, Kansas 64128
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Kingman

    Kingman, Kansas 67068
    United States

    Site Not Available

  • Southwest Medical Center

    Liberal, Kansas 67901
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Newton

    Newton, Kansas 67114
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Parsons

    Parsons, Kansas 67357
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Pratt

    Pratt, Kansas 67124
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Salina

    Salina, Kansas 67042
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Wellington

    Wellington, Kansas 67152
    United States

    Site Not Available

  • Associates in Womens Health, PA - North Review

    Wichita, Kansas 67203
    United States

    Site Not Available

  • CCOP - Wichita

    Wichita, Kansas 67214
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Medical Arts Tower

    Wichita, Kansas 67208
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Wichita

    Wichita, Kansas 67214
    United States

    Site Not Available

  • Via Christi Cancer Center at Via Christi Regional Medical Center

    Wichita, Kansas 67214
    United States

    Site Not Available

  • Wesley Medical Center

    Wichita, Kansas 67214
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Winfield

    Winfield, Kansas 67156
    United States

    Site Not Available

  • Markey Cancer Center at University of Kentucky Chandler Medical Center

    Lexington, Kentucky 40536-0293
    United States

    Site Not Available

  • Louisiana State University Health Sciences Center - Monroe

    Monroe, Louisiana 71210
    United States

    Site Not Available

  • Feist-Weiller Cancer Center at Louisiana State University Health Sciences

    Shreveport, Louisiana 71130-3932
    United States

    Site Not Available

  • Veterans Affairs Medical Center - Shreveport

    Shreveport, Louisiana 71101
    United States

    Site Not Available

  • Cancer Research Center at Boston Medical Center

    Boston, Massachusetts 02118
    United States

    Site Not Available

  • Lahey Clinic Medical Center - Burlington

    Burlington, Massachusetts 01805
    United States

    Site Not Available

  • Commonwealth Hematology-Oncology P.C. - Worcester

    Worcester, Massachusetts 01605
    United States

    Site Not Available

  • CCOP - Michigan Cancer Research Consortium

    Ann Arbor, Michigan 48106
    United States

    Site Not Available

  • Saint Joseph Mercy Cancer Center

    Ann Arbor, Michigan 48106-0995
    United States

    Site Not Available

  • University of Michigan Comprehensive Cancer Center

    Ann Arbor, Michigan 48109-0942
    United States

    Site Not Available

  • Mecosta County Medical Center

    Big Rapids, Michigan 49307
    United States

    Site Not Available

  • Barbara Ann Karmanos Cancer Institute

    Detroit, Michigan 48201-1379
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Escanaba

    Escanaba, Michigan 49431
    United States

    Site Not Available

  • Genesys Hurley Cancer Institute

    Flint, Michigan 48503
    United States

    Site Not Available

  • Hurley Medical Center

    Flint, Michigan 48503
    United States

    Site Not Available

  • CCOP - Grand Rapids

    Grand Rapids, Michigan 49503
    United States

    Site Not Available

  • Lacks Cancer Center at Saint Mary's Health Care

    Grand Rapids, Michigan 49503
    United States

    Site Not Available

  • Metro Health Hospital

    Grand Rapids, Michigan 49506
    United States

    Site Not Available

  • Spectrum Health Hospital - Butterworth Campus

    Grand Rapids, Michigan 49503
    United States

    Site Not Available

  • Van Elslander Cancer Center at St. John Hospital and Medical Center

    Grosse Pointe Woods, Michigan 48236
    United States

    Site Not Available

  • Holland Community Hospital

    Holland, Michigan 49423
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Iron Mountain

    Iron Mountain, Michigan 49801
    United States

    Site Not Available

  • Foote Hospital

    Jackson, Michigan 49201
    United States

    Site Not Available

  • Sparrow Regional Cancer Center

    Lansing, Michigan 48909
    United States

    Site Not Available

  • Hackley Hospital

    Muskegon, Michigan 49442
    United States

    Site Not Available

  • Northern Michigan Hospital

    Petoskey, Michigan 49770
    United States

    Site Not Available

  • Mercy Regional Cancer Center at Mercy Hospital

    Port Huron, Michigan 48060
    United States

    Site Not Available

  • William Beaumont Hospital - Royal Oak Campus

    Royal Oak, Michigan 48073
    United States

    Site Not Available

  • Seton Cancer Institute - Saginaw

    Saginaw, Michigan 48601
    United States

    Site Not Available

  • Munson Medical Center

    Traverse City, Michigan 49684
    United States

    Site Not Available

  • St. John Macomb Hospital

    Warren, Michigan 48093
    United States

    Site Not Available

  • Alexandria, Minnesota 56308
    United States

    Site Not Available

  • Brainerd Medical Center

    Brainerd, Minnesota 56401
    United States

    Site Not Available

  • St. Joseph's Medical Center

    Brainerd, Minnesota 56401
    United States

    Site Not Available

  • Fergus Falls, Minnesota 56537
    United States

    Site Not Available

  • Chippewa County - Montevideo Hospital

    Montevideo, Minnesota 56265
    United States

    Site Not Available

  • CentraCare Clinic - River Campus

    Saint Cloud, Minnesota 56303
    United States

    Site Not Available

  • Coborn Cancer Center

    Saint Cloud, Minnesota 56303
    United States

    Site Not Available

  • Adult and Pediatric Urology, P.L.L.P.

    Sartell, Minnesota 56377
    United States

    Site Not Available

  • CentraCare Clinic - River Campus

    St. Cloud, Minnesota 56303
    United States

    Site Not Available

  • Saint Francis Medical Center

    Cape Girardeau, Missouri 63701
    United States

    Site Not Available

  • Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital

    Cape Girardeau, Missouri 63701
    United States

    Site Not Available

  • Saint Luke's Hospital

    Chesterfield, Missouri 63017
    United States

    Site Not Available

  • Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital

    Gape Girardeau, Missouri 63701
    United States

    Site Not Available

  • CCOP - Kansas City

    Kansas City, Missouri 64131
    United States

    Site Not Available

  • Arch Medical Services, Incorporated at Center for Cancer Care Research

    Saint Louis, Missouri 63141
    United States

    Site Not Available

  • CCOP - St. Louis-Cape Girardeau

    Saint Louis, Missouri 63141
    United States

    Site Not Available

  • David C. Pratt Cancer Center at St. John's Mercy

    Saint Louis, Missouri 63141
    United States

    Site Not Available

  • Missouri Baptist Cancer Center

    Saint Louis, Missouri 63131
    United States

    Site Not Available

  • Siteman Cancer Center at Barnes-Jewish Hospital

    Saint Louis, Missouri 63110
    United States

    Site Not Available

  • Siteman Cancer Center at Barnes-Jewish Hospital

    St Louis, Missouri 63110
    United States

    Site Not Available

  • Missouri Baptist Cancer Center

    St. Louis, Missouri 63131
    United States

    Site Not Available

  • Billings Clinic Cancer Center

    Billings, Montana 59107-5100
    United States

    Site Not Available

  • CCOP - Montana Cancer Consortium

    Billings, Montana 59101
    United States

    Site Not Available

  • Deaconess Billings Clinic - Downtown

    Billings, Montana 59107-7000
    United States

    Site Not Available

  • Hematology-Oncology Centers of the Northern Rockies - Billings

    Billings, Montana 59101
    United States

    Site Not Available

  • St. Vincent Healthcare

    Billings, Montana 59101
    United States

    Site Not Available

  • Bozeman Deaconess Hospital

    Bozeman, Montana 59715
    United States

    Site Not Available

  • St. James Community Hospital

    Butte, Montana 59701
    United States

    Site Not Available

  • Great Falls Clinic

    Great Falls, Montana 59405
    United States

    Site Not Available

  • Sletten Regional Cancer Institute at Benefis Healthcare

    Great Falls, Montana 59405
    United States

    Site Not Available

  • Great Falls, Montana 59405
    United States

    Site Not Available

  • St. Peter's Hospital

    Helena, Montana 59601
    United States

    Site Not Available

  • Glacier Oncology, PLLC

    Kalispell, Montana 59901
    United States

    Site Not Available

  • Kalispell Medical Oncology

    Kalispell, Montana 59901
    United States

    Site Not Available

  • Kalispell Regional Medical Center

    Kalispell, Montana 59901
    United States

    Site Not Available

  • Community Medical Center

    Missoula, Montana 59801
    United States

    Site Not Available

  • Guardian Oncology and Center for Wellness

    Missoula, Montana 59804
    United States

    Site Not Available

  • Montana Cancer Center at St. Patrick Hospital and Health Sciences Center

    Missoula, Montana 59807
    United States

    Site Not Available

  • Montana Cancer Specialists at Montana Cancer Center

    Missoula, Montana 59807-7877
    United States

    Site Not Available

  • Good Samaritan Cancer Center at Good Samaritan Hospital

    Kearney, Nebraska 68848-1990
    United States

    Site Not Available

  • CCOP - Nevada Cancer Research Foundation

    Las Vegas, Nevada 89106
    United States

    Site Not Available

  • University Medical Center of Southern Nevada

    Las Vegas, Nevada 89102
    United States

    Site Not Available

  • Kingsbury Center for Cancer Care at Cheshire Medical Center

    Keene, New Hampshire 03431
    United States

    Site Not Available

  • Lakes Region General Hospital

    Laconia, New Hampshire 03246
    United States

    Site Not Available

  • Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center

    Lebanon, New Hampshire 03756-0002
    United States

    Site Not Available

  • Elliot Regional Cancer Center at Elliot Hospital

    Manchester, New Hampshire 03103
    United States

    Site Not Available

  • Frisbie Memorial Hospital

    Rochester, New Hampshire 03867
    United States

    Site Not Available

  • Cancer Institute of New Jersey at Hamilton

    Hamilton, New Jersey 08690
    United States

    Site Not Available

  • Mountainside Hospital Cancer Center

    Montclair, New Jersey 07042
    United States

    Site Not Available

  • Carol G. Simon Cancer Center at Morristown Memorial Hospital

    Morristown, New Jersey 07962
    United States

    Site Not Available

  • Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School

    New Brunswick, New Jersey 08903
    United States

    Site Not Available

  • University of New Mexico Cancer Research and Treatment Center

    Albuquerque, New Mexico 87131-5636
    United States

    Site Not Available

  • Veterans Affairs Medical Center - Brooklyn

    Brooklyn, New York 11209
    United States

    Site Not Available

  • Veterans Affairs Medical Center - Buffalo

    Buffalo, New York 14215
    United States

    Site Not Available

  • James P. Wilmot Cancer Center at University of Rochester Medical Center

    Rochester, New York 14642
    United States

    Site Not Available

  • Duke Comprehensive Cancer Center

    Durham, North Carolina 27710
    United States

    Site Not Available

  • Wayne Memorial Hospital, Incorporated

    Goldsboro, North Carolina 27534
    United States

    Site Not Available

  • Pardee Memorial Hospital

    Hendersonville, North Carolina 28791
    United States

    Site Not Available

  • Lenoir Memorial Cancer Center

    Kinston, North Carolina 28501
    United States

    Site Not Available

  • Rutherford Hospital

    Rutherfordton, North Carolina 28139
    United States

    Site Not Available

  • Bismarck Cancer Center

    Bismarck, North Dakota 58501
    United States

    Site Not Available

  • Cancer Care Center at Medcenter One Hospital

    Bismarck, North Dakota 58501
    United States

    Site Not Available

  • Mid Dakota Clinic, PC

    Bismarck, North Dakota 58501
    United States

    Site Not Available

  • St. Alexius Medical Center

    Bismarck, North Dakota 58502
    United States

    Site Not Available

  • Akron City Hospital

    Akron, Ohio 44309-2090
    United States

    Site Not Available

  • Community Hospitals and Wellness Centers - Bryan

    Bryan, Ohio 43506
    United States

    Site Not Available

  • Cleveland Clinic Taussig Cancer Center

    Cleveland, Ohio 44195
    United States

    Site Not Available

  • Community Oncology Group at Cleveland Clinic Cancer Center

    Independence, Ohio 44131
    United States

    Site Not Available

  • St. Rita's Medical Center

    Lima, Ohio 45801
    United States

    Site Not Available

  • Cleveland Clinic - Wooster

    Wooster, Ohio 44691
    United States

    Site Not Available

  • Tod Children's Hospital - Forum Health

    Youngstown, Ohio 44501
    United States

    Site Not Available

  • OU Cancer Institute

    Oklahoma City, Oklahoma 73104
    United States

    Site Not Available

  • St. Charles Medical Center - Bend

    Bend, Oregon 97701
    United States

    Site Not Available

  • Legacy Mount Hood Medical Center

    Gresham, Oregon 97030
    United States

    Site Not Available

  • Providence Milwaukie Hospital

    Milwaukie, Oregon 97222
    United States

    Site Not Available

  • CCOP - Columbia River Oncology Program

    Portland, Oregon 97225
    United States

    Site Not Available

  • Legacy Emanuel Hospital and Health Center & Children's Hospital

    Portland, Oregon 97227
    United States

    Site Not Available

  • Legacy Good Samaritan Hospital & Medical Center Comprehensive Cancer Center

    Portland, Oregon 97210
    United States

    Site Not Available

  • Providence Cancer Center at Providence Portland Medical Center

    Portland, Oregon 97213-2967
    United States

    Site Not Available

  • Providence St. Vincent Medical Center

    Portland, Oregon 97225
    United States

    Site Not Available

  • Legacy Meridian Park Hospital

    Tualatin, Oregon 97062
    United States

    Site Not Available

  • Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest

    Allentown, Pennsylvania 18105
    United States

    Site Not Available

  • PinnacleHealth Regional Cancer Center at Polyclinic Hospital

    Harrisburg, Pennsylvania 17105
    United States

    Site Not Available

  • Hillman Cancer Center at University of Pittsburgh Cancer Institute

    Pittsburgh, Pennsylvania 15232
    United States

    Site Not Available

  • Cancer Care Institute of Carolina at Aiken Regional Medical Centers

    Aiken, South Carolina 29801
    United States

    Site Not Available

  • AnMed Health Cancer Center

    Anderson, South Carolina 29621
    United States

    Site Not Available

  • Hollings Cancer Center at Medical University of South Carolina

    Charleston, South Carolina 29425
    United States

    Site Not Available

  • Roper St. Francis Cancer Center at Roper Hospital

    Charleston, South Carolina 29401
    United States

    Site Not Available

  • CCOP - Upstate Carolina

    Spartanburg, South Carolina 29303
    United States

    Site Not Available

  • Gibbs Regional Cancer Center at Spartanburg Regional Medical Center

    Spartanburg, South Carolina 29303
    United States

    Site Not Available

  • Mountainview Medical

    Berlin, Vermont 05602
    United States

    Site Not Available

  • Mountainview Medical

    Berlin Corners, Vermont 05602
    United States

    Site Not Available

  • Fletcher Allen Health Care - University Health Center Campus

    Burlington, Vermont 05401
    United States

    Site Not Available

  • St. Joseph Cancer Center

    Bellingham, Washington 98225
    United States

    Site Not Available

  • Olympic Hematology and Oncology

    Bremerton, Washington 98310
    United States

    Site Not Available

  • Skagit Valley Hospital Cancer Care Center

    Mount Vernon, Washington 98273
    United States

    Site Not Available

  • Fred Hutchinson Cancer Research Center

    Seattle, Washington 98104
    United States

    Site Not Available

  • Group Health Central Hospital

    Seattle, Washington 98112
    United States

    Site Not Available

  • Harborview Medical Center

    Seattle, Washington 98104
    United States

    Site Not Available

  • Minor and James Medical, PLLC

    Seattle, Washington 98104
    United States

    Site Not Available

  • Polyclinic First Hill

    Seattle, Washington 98122
    United States

    Site Not Available

  • Swedish Cancer Institute at Swedish Medical Center - First Hill Campus

    Seattle, Washington 98122-4307
    United States

    Site Not Available

  • University Cancer Center at University of Washington Medical Center

    Seattle, Washington 98195-6043
    United States

    Site Not Available

  • North Puget Oncology at United General Hospital

    Sedro-Wooley, Washington 98284
    United States

    Site Not Available

  • North Puget Oncology at United General Hospital

    Sedro-Woolley, Washington 98284
    United States

    Site Not Available

  • Cancer Care Northwest - Spokane South

    Spokane, Washington 99202
    United States

    Site Not Available

  • Rockwood Clinic Cancer Treatment Center

    Spokane, Washington 99204-2967
    United States

    Site Not Available

  • Madigan Army Medical Center - Tacoma

    Tacoma, Washington 98431
    United States

    Site Not Available

  • Southwest Washington Medical Center Cancer Center

    Vancouver, Washington 98668
    United States

    Site Not Available

  • Wenatchee Valley Medical Center

    Wenatchee, Washington 98801-2028
    United States

    Site Not Available

  • North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

    Yakima, Washington 98902
    United States

    Site Not Available

  • Fox Valley Hematology and Oncology - East Grant Street

    Appleton, Wisconsin 54911-3496
    United States

    Site Not Available

  • Green Bay Oncology, Limited at St. Mary's Hospital

    Green Bay, Wisconsin 54303
    United States

    Site Not Available

  • Green Bay Oncology, Limited at St. Vincent Hospital

    Green Bay, Wisconsin 54301-3526
    United States

    Site Not Available

  • St. Mary's Hospital Medical Center - Green Bay

    Green Bay, Wisconsin 54303
    United States

    Site Not Available

  • St. Vincent Hospital Regional Cancer Center

    Green Bay, Wisconsin 54307-3508
    United States

    Site Not Available

  • Dean Medical Center - Madison

    Madison, Wisconsin 53717
    United States

    Site Not Available

  • University of Wisconsin Comprehensive Cancer Center

    Madison, Wisconsin 53792-6164
    United States

    Site Not Available

  • Bay Area Cancer Care Center at Bay Area Medical Center

    Marinette, Wisconsin 54143
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Oconto Falls

    Oconto Falls, Wisconsin 54154
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Sturgeon Bay

    Sturgeon Bay, Wisconsin 54235
    United States

    Site Not Available

  • University of Wisconcin Cancer Center at Aspirus Wausau Hospital

    Wausau, Wisconsin 54401
    United States

    Site Not Available

  • Welch Cancer Center at Sheridan Memorial Hospital

    Sheridan, Wyoming 82801
    United States

    Site Not Available

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