S0008: Chemotherapy Plus Biological Therapy in Treating Patients With Melanoma

Last updated: March 5, 2015
Sponsor: Southwest Oncology Group
Overall Status: Completed

Phase

3

Condition

Melanoma

Treatment

N/A

Clinical Study ID

NCT00006237
S0008
U10CA032102
ECOG-S0008
COG-S0008
S0008
CALGB-500002
  • Ages > 18
  • All Genders

Study Summary

RATIONALE: Interferon alfa may interfere with the growth of cancer cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Interleukin-2 may stimulate a person's white blood cells to kill melanoma cells. It is not yet known whether interferon alfa is more effective with or without combination chemotherapy and interleukin-2 for melanoma.

PURPOSE: Randomized phase III trial to compare the effectiveness of interferon alfa with or without combination chemotherapy consisting of cisplatin, vinblastine, and dacarbazine, plus interleukin-2, in treating patients who have melanoma.

Eligibility Criteria

Inclusion

DISEASE CHARACTERISTICS:

  • Histologically proven melanoma of cutaneous origin or from unknown primary at initial presentation of primary or first clinically detected nodal or satellite/in-transit recurrence

  • No distant metastases

  • No melanoma of ocular, mucosal, or other non-cutaneous origin

  • One of the following criteria must apply for patients with newly diagnosed melanoma OR a previously diagnosed primary with current subsequent, clinical, regional nodal disease and/or satellite/in-transit disease:

  • Ulcerated primary melanoma with 1 or more involved lymph nodes (micro/occult or macro/clinically overt)

  • Non-ulcerated or unknown primary melanoma with one macro/clinically overt lymph node metastasis, including a single matted nodal mass

  • No non-ulcerated or unknown primary tumor and a single micrometastatic lymph node

  • Non-ulcerated melanoma with two or more lymph node metastases (micro/occult or macro/clinically overt) and/or matted nodes

  • Any satellite/in transit metastasis with or without lymph node involvement

  • Patients with recurrent disease must have recurrent disease in the regional nodal basin of a prior complete lymphadenectomy

  • Multiple regional nodal basin involvement allowed if they are appropriate anatomic drainage basins for primary site

  • Patients must be disease free at time of enrollment based on the following surgical criteria:

  • Patients at initial presentation of melanoma must undergo adequate wide excision of primary lesion

  • Patients with previously diagnosed melanoma must have all disease resected with pathologically negative margins and no disease at primary site or second resection of primary

  • Full lymphadenectomy required of all patients including those with positive sentinel nodes or positive satellite/in-transit metastasis

  • No more than 56 days since prior lymphadenectomy OR surgery to remove recurrent disease after prior complete lymphadenectomy

  • Must be willing to participate in minimal residual disease studies if registered on the study on 3/1/2003 or later

PATIENT CHARACTERISTICS:

Age:

  • 18 and over

Performance status:

  • Zubrod 0-1

Life expectancy:

  • Not specified

Hematopoietic:

  • Absolute granulocyte count at least 1,500/mm^3

  • Platelet count at least 100,000/mm^3

Hepatic:

  • Bilirubin no greater than 1.5 times upper limit of normal (ULN)

  • SGOT or SGPT no greater than 2 times ULN

  • LDH and alkaline phosphatase no greater than 2 times ULN (above normal value requires a contrast-enhanced CT scan or MRI of liver)

  • No known recent hepatitis positivity by PCR

Renal:

  • Creatinine no greater than 1.5 mg/dL OR

  • Creatinine clearance at least 75 mL/min

Cardiovascular:

  • No congestive heart failure

  • No coronary artery disease

  • No serious cardiac arrhythmia

  • No prior myocardial infarction

  • Normal cardiac stress test required if any of the following are present:

  • Over age 50

  • Abnormal EKG

  • History of cardiac disease

Pulmonary:

  • No symptomatic pulmonary disease

Other:

  • Not pregnant or nursing

  • Negative pregnancy test

  • Fertile patients must use effective contraception

  • No autoimmune disorders or conditions of immunosuppression

  • No other prior malignancy within the past 5 years except the following:

  • Adequately treated basal cell or squamous cell skin cancer

  • Carcinoma in situ of the cervix

  • Adequately treated stage I or II cancer in remission

  • HIV negative

  • No known AIDS or HIV-1 associated complex

PRIOR CONCURRENT THERAPY:

Biologic therapy:

  • No prior immunotherapy, including interferon, interleukin, levamisole, or other biologic response modifiers

  • No other concurrent biologic therapy

Chemotherapy:

  • No prior chemotherapy (including infusion or perfusion therapy)

  • No other concurrent chemotherapy

Endocrine therapy:

  • No concurrent systemic corticosteroids or topical steroid creams

  • Concurrent steroid antihistamines allowed if no alternative

  • No concurrent hormonal therapy

Radiotherapy:

  • No prior radiotherapy

  • Prior postlumpectomy radiotherapy for breast cancer allowed

  • No concurrent radiotherapy

Surgery:

  • See Disease Characteristics

  • No concurrent surgery

Other:

  • No concurrent anti-hypertensive medications (arm II only)

  • No concurrent immunosuppressive agents

  • No other concurrent anticancer therapy

  • Antihistamines allowed if no alternative medication suitable

Study Design

Total Participants: 432
Study Start date:
August 01, 2000
Estimated Completion Date:
July 31, 2012

Study Description

OBJECTIVES:

  • Compare the overall survival and disease-free survival of patients with high-risk melanoma treated with interferon alfa vs cisplatin, vinblastine, and dacarbazine plus interferon alfa and interleukin-2.

  • Compare the toxic effects of these treatment regimens in these patients.

  • Determine the relationship between minimal residual disease (MRD) status at 12 weeks and 52 weeks and overall survival of patients treated with these regimens.

  • Compare the effects of these treatment regimens on the MRD status of these patients.

  • Determine the relationship between clinical characteristics (number of involved lymph nodes, ulcerated primary, and extracapsular extension) and MRD in patients treated with these regimens.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to nodal status (N1 or N2 vs N3), degree of lymph node involvement (micrometastases only vs any macrometastases, including satellite/in-transit metastases), and ulceration of the primary tumor (yes vs no vs unknown primary). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients receive interferon alfa IV on days 1-5 of weeks 1-4 followed by interferon alfa subcutaneously (SC) on days 1, 3, and 5 of weeks 5-52 in the absence of disease progression or unacceptable toxicity.

  • Arm II: Patients receive cisplatin IV over 30 minutes followed by vinblastine IV on days 1-4. Patients also receive dacarbazine IV over 1 hour on day 1, interleukin-2 IV over 96 hours on days 1-4, and interferon alfa SC on days 1-5, 8, 10, and 12. In addition, patients receive filgrastim (G-CSF) SC on days 6-15. Treatment repeats every 3 weeks for 3 courses in the absence of disease progression or unacceptable toxicity.

Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then annually for 5 years.

PROJECTED ACCRUAL: A total of 410 patients (205 per treatment arm) will be accrued for this study within 3 years.

Connect with a study center

  • Princess Margaret Hospital for Children

    Perth, Western Australia 6001
    Australia

    Site Not Available

  • Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham

    Birmingham, Alabama 35294
    United States

    Site Not Available

  • Mobile Infirmary Medical Center

    Mobile, Alabama 36652-2144
    United States

    Site Not Available

  • Banner Thunderbird Medical Center

    Glendale, Arizona 85306
    United States

    Site Not Available

  • Banner Good Samaritan Medical Center

    Phoenix, Arizona 85006
    United States

    Site Not Available

  • CCOP - Western Regional, Arizona

    Phoenix, Arizona 85006
    United States

    Site Not Available

  • Phoenix Children's Hospital

    Phoenix, Arizona 85016-7710
    United States

    Site Not Available

  • Arizona Cancer Center at University of Arizona Health Sciences Center

    Tucson, Arizona 85724-5024
    United States

    Site Not Available

  • Hembree Mercy Cancer Center at St. Edward Mercy Medical Center

    Ft. Smith, Arkansas 72903
    United States

    Site Not Available

  • Arkansas Cancer Research Center at University of Arkansas for Medical Sciences

    Little Rock, Arkansas 72205
    United States

    Site Not Available

  • Eden Medical Center

    Castro Valley, California 94546
    United States

    Site Not Available

  • Saint Rose Hospital

    Hayward, California 94545
    United States

    Site Not Available

  • Rebecca and John Moores UCSD Cancer Center

    La Jolla, California 92093-0658
    United States

    Site Not Available

  • Alta Bates Summit Medical Center - Summit Campus

    Oakland, California 94609
    United States

    Site Not Available

  • CCOP - Bay Area Tumor Institute

    Oakland, California 94609
    United States

    Site Not Available

  • Highland General Hospital

    Oakland, California 94602
    United States

    Site Not Available

  • Valley Care Medical Center

    Pleasanton, California 94588
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Oakland

    Sacramento, California 95825
    United States

    Site Not Available

  • Scripps Cancer Center - San Diego

    San Diego, California 92121
    United States

    Site Not Available

  • Veterans Affairs Medical Center - San Diego

    San Diego, California 92161
    United States

    Site Not Available

  • Doctors Medical Center - San Pablo Campus

    San Pablo, California 94806
    United States

    Site Not Available

  • CCOP - Santa Rosa Memorial Hospital

    Sana Rosa, California 95405
    United States

    Site Not Available

  • Front Range Cancer Specialists

    Fort Collins, Colorado 80528
    United States

    Site Not Available

  • Poudre Valley Hospital

    Fort Collins, Colorado 80524
    United States

    Site Not Available

  • Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center

    Farmington, Connecticut 06360-2875
    United States

    Site Not Available

  • George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus

    New Britain, Connecticut 06050
    United States

    Site Not Available

  • Eastern Connecticut Hematology and Oncology Associates

    Norwich, Connecticut 06360
    United States

    Site Not Available

  • Tunnell Cancer Center at Beebe Medical Center

    Lewes, Delaware 19958
    United States

    Site Not Available

  • CCOP - Christiana Care Health Services

    Newark, Delaware 19713
    United States

    Site Not Available

  • Children's National Medical Center

    Washington, District of Columbia 20010-2970
    United States

    Site Not Available

  • Baptist Cancer Institute - Jacksonville

    Jacksonville, Florida 32207
    United States

    Site Not Available

  • All Children's Hospital

    St. Petersburg, Florida 33701
    United States

    Site Not Available

  • St. Joseph's Cancer Institute at St. Joseph's Hospital

    Tampa, Florida 33607
    United States

    Site Not Available

  • Kaplan Cancer Center at St. Mary's Medical Center

    West Palm Beach, Florida 33407
    United States

    Site Not Available

  • Winship Cancer Institute of Emory University

    Altanta, Georgia 30322
    United States

    Site Not Available

  • Veterans Affairs Medical Center - Atlanta (Decatur)

    Decatur, Georgia 30033
    United States

    Site Not Available

  • Pearlman Comprehensive Cancer Center at South Georgia Medical Center

    Valdosta, Georgia 31603
    United States

    Site Not Available

  • Mountain States Tumor Institute at St. Luke's Regional Medical Center

    Boise, Idaho 83712
    United States

    Site Not Available

  • Rush-Copley Cancer Care Center

    Aurora, Illinois 60507
    United States

    Site Not Available

  • St. Joseph Medical Center

    Bloomington, Illinois 61701
    United States

    Site Not Available

  • Graham Hospital

    Canton, Illinois 61520
    United States

    Site Not Available

  • Memorial Hospital

    Carthage, Illinois 62321
    United States

    Site Not Available

  • Hematology and Oncology Associates

    Chicago, Illinois 60611
    United States

    Site Not Available

  • Mercy Hospital and Medical Center

    Chicago, Illinois 60616
    United States

    Site Not Available

  • Robert H. Lurie Comprehensive Cancer Center at Northwestern University

    Chicago, Illinois 60611-3013
    United States

    Site Not Available

  • Swedish Covenant Hospital

    Chicago, Illinois 60625
    United States

    Site Not Available

  • University of Illinois Cancer Center

    Chicago, Illinois 60612-7243
    United States

    Site Not Available

  • Veterans Affairs Medical Center - Chicago Westside Hospital

    Chicago, Illinois 60612
    United States

    Site Not Available

  • Sherman Hospital

    Elgin, Illinois 60120
    United States

    Site Not Available

  • Eureka Community Hospital

    Eureka, Illinois 61530
    United States

    Site Not Available

  • Evanston Northwestern Healthcare - Evanston Hospital

    Evanston, Illinois 60201-1781
    United States

    Site Not Available

  • Galesburg Clinic, PC

    Galesburg, Illinois 61401
    United States

    Site Not Available

  • Galesburg Cottage Hospital

    Galesburg, Illinois 61401
    United States

    Site Not Available

  • Mason District Hospital

    Havana, Illinois 62644
    United States

    Site Not Available

  • Hopedale Medical Complex

    Hopedale, Illinois 61747
    United States

    Site Not Available

  • Joliet Oncology-Hematology Associates, Limited - West

    Joliet, Illinois 60435
    United States

    Site Not Available

  • Midwest Center for Hematology/Oncology

    Joliet, Illinois 60432
    United States

    Site Not Available

  • Kewanee Hospital

    Kewanee, Illinois 61443
    United States

    Site Not Available

  • McDonough District Hospital

    Macomb, Illinois 61455
    United States

    Site Not Available

  • Cardinal Bernardin Cancer Center at Loyola University Medical Center

    Maywood, Illinois 60153
    United States

    Site Not Available

  • Cancer Care and Hematology Specialists of Chicagoland - Niles

    Niles, Illinois 60714
    United States

    Site Not Available

  • BroMenn Regional Medical Center

    Normal, Illinois 61761
    United States

    Site Not Available

  • Community Cancer Center

    Normal, Illinois 61761
    United States

    Site Not Available

  • Community Hospital of Ottawa

    Ottawa, Illinois 61350
    United States

    Site Not Available

  • Oncology Hematology Associates of Central Illinois, PC - Ottawa

    Ottawa, Illinois 61350
    United States

    Site Not Available

  • Cancer Treatment Center at Pekin Hospital

    Pekin, Illinois 61554
    United States

    Site Not Available

  • CCOP - Illinois Oncology Research Association

    Peoria, Illinois 61615
    United States

    Site Not Available

  • Methodist Medical Center of Illinois

    Peoria, Illinois 61636
    United States

    Site Not Available

  • OSF St. Francis Medical Center

    Peoria, Illinois 61637
    United States

    Site Not Available

  • Oncology Hematology Associates of Central Illinois, PC - Peoria

    Peoria, Illinois 61615
    United States

    Site Not Available

  • Proctor Hospital

    Peoria, Illinois 61614
    United States

    Site Not Available

  • Saint Jude Midwest Affiliate

    Peoria, Illinois 61637
    United States

    Site Not Available

  • Illinois Valley Community Hospital

    Peru, Illinois 61354
    United States

    Site Not Available

  • Perry Memorial Hospital

    Princeton, Illinois 61356
    United States

    Site Not Available

  • Swedish-American Regional Cancer Center

    Rockford, Illinois 61104-2315
    United States

    Site Not Available

  • Hematology Oncology Associates - Skokie

    Skokie, Illinois 60076
    United States

    Site Not Available

  • Hematology/Oncology of the North Shore at Gross Point Medical Center

    Skokie, Illinois 60076
    United States

    Site Not Available

  • St. Margaret's Hospital

    Spring Valley, Illinois 61362
    United States

    Site Not Available

  • CCOP - Carle Cancer Center

    Urbana, Illinois 61801
    United States

    Site Not Available

  • Carle Cancer Center at Carle Foundation Hospital

    Urbana, Illinois 61801
    United States

    Site Not Available

  • Elkhart General Hospital

    Elkhart, Indiana 46515
    United States

    Site Not Available

  • Howard Community Hospital

    Kokomo, Indiana 46904
    United States

    Site Not Available

  • Center for Cancer Therapy at LaPorte Hospital and Health Services

    La Porte, Indiana 46350
    United States

    Site Not Available

  • Saint Anthony Memorial Health Centers

    Michigan City, Indiana 46360
    United States

    Site Not Available

  • CCOP - Northern Indiana CR Consortium

    South Bend, Indiana 46601
    United States

    Site Not Available

  • Memorial Hospital of South Bend

    South Bend, Indiana 46601
    United States

    Site Not Available

  • Saint Joseph Regional Medical Center

    South Bend, Indiana 46617
    United States

    Site Not Available

  • McFarland Clinic, PC

    Ames, Iowa 50010
    United States

    Site Not Available

  • Genesis Regional Cancer Center at Genesis Medical Center

    Davenport, Iowa 52803
    United States

    Site Not Available

  • CCOP - Iowa Oncology Research Association

    Des Moines, Iowa 50309
    United States

    Site Not Available

  • John Stoddard Cancer Center at Iowa Lutheran Hospital

    Des Moines, Iowa 50316
    United States

    Site Not Available

  • John Stoddard Cancer Center at Iowa Methodist Medical Center

    Des Moines, Iowa 50309
    United States

    Site Not Available

  • Medical Oncology and Hematology Associates at John Stoddard Cancer Center

    Des Moines, Iowa 50309
    United States

    Site Not Available

  • Medical Oncology and Hematology Associates at Mercy Cancer Center

    Des Moines, Iowa 50314
    United States

    Site Not Available

  • Mercy Cancer Center at Mercy Medical Center - Des Moines

    Des Moines, Iowa 50314
    United States

    Site Not Available

  • Mercy Capitol Hospital

    Des Moines, Iowa 50307
    United States

    Site Not Available

  • Holden Comprehensive Cancer Center at University of Iowa

    Iowa City, Iowa 52242-1002
    United States

    Site Not Available

  • Veterans Affairs Medical Center - Kansas City

    Kansas City, Kansas 64128
    United States

    Site Not Available

  • Tammy Walker Cancer Center at Salina Regional Health Center

    Salina, Kansas 67401
    United States

    Site Not Available

  • Cotton-O'Neil Cancer Center

    Topeka, Kansas 66606
    United States

    Site Not Available

  • St. Francis Comprehensive Cancer Center

    Topeka, Kansas 66606
    United States

    Site Not Available

  • Louisiana State University Health Sciences Center - Monroe

    Monroe, Louisiana 71210
    United States

    Site Not Available

  • Feist-Weiller Cancer Center at Louisiana State University Health Sciences

    Shreveport, Louisiana 71130-3932
    United States

    Site Not Available

  • Union Hospital Cancer Program at Union Hospital

    Elkton MD, Maryland 21921
    United States

    Site Not Available

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts 02215
    United States

    Site Not Available

  • Boston University Cancer Research Center

    Boston, Massachusetts 02118
    United States

    Site Not Available

  • Tufts-NEMC Cancer Center

    Boston, Massachusetts 02111
    United States

    Site Not Available

  • CCOP - Michigan Cancer Research Consortium

    Ann Arbor, Michigan 48106
    United States

    Site Not Available

  • Saint Joseph Mercy Cancer Center

    Ann Arbor, Michigan 48106-0995
    United States

    Site Not Available

  • University of Michigan Comprehensive Cancer Center

    Ann Arbor, Michigan 48109-0942
    United States

    Site Not Available

  • Battle Creek Health System Cancer Care Center

    Battle Creek, Michigan 49017
    United States

    Site Not Available

  • Mecosta County Medical Center

    Big Rapids, Michigan 49307
    United States

    Site Not Available

  • Oakwood Cancer Center at Oakwood Hospital and Medical Center

    Dearborn, Michigan 48123-2500
    United States

    Site Not Available

  • Barbara Ann Karmanos Cancer Institute

    Detroit, Michigan 48201-1379
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Escanaba

    Escanaba, Michigan 49431
    United States

    Site Not Available

  • Genesys Hurley Cancer Institute

    Flint, Michigan 48503
    United States

    Site Not Available

  • Great Lakes Cancer Institute at McLaren Regional Medical Center

    Flint, Michigan 48532
    United States

    Site Not Available

  • Hurley Medical Center

    Flint, Michigan 48503
    United States

    Site Not Available

  • Butterworth Hospital at Spectrum Health

    Grand Rapids, Michigan 49503
    United States

    Site Not Available

  • CCOP - Grand Rapids

    Grand Rapids, Michigan 49503
    United States

    Site Not Available

  • Lacks Cancer Center at Saint Mary's Health Care

    Grand Rapids, Michigan 49503
    United States

    Site Not Available

  • Metro Health Hospital

    Grand Rapids, Michigan 49506
    United States

    Site Not Available

  • Van Elslander Cancer Center at St. John Hospital and Medical Center

    Grosse Pointe Woods, Michigan 48236
    United States

    Site Not Available

  • Holland Community Hospital

    Holland, Michigan 49423
    United States

    Site Not Available

  • Dickinson County Healthcare System

    Iron Mountain, Michigan 49801
    United States

    Site Not Available

  • Foote Memorial Hospital

    Jackson, Michigan 49201
    United States

    Site Not Available

  • Borgess Medical Center

    Kalamazoo, Michigan 49001
    United States

    Site Not Available

  • Bronson Methodist Hospital

    Kalamazoo, Michigan 49007
    United States

    Site Not Available

  • West Michigan Cancer Center

    Kalamazoo, Michigan 49007-3731
    United States

    Site Not Available

  • Sparrow Regional Cancer Center

    Lansing, Michigan 48912-1811
    United States

    Site Not Available

  • Upper Michigan Cancer Center at Marquette General Hospital

    Marquette, Michigan 49855
    United States

    Site Not Available

  • Hackley Hospital

    Muskegon, Michigan 49442
    United States

    Site Not Available

  • William Beaumont Hospital - Royal Oak Campus

    Royal Oak, Michigan 48073
    United States

    Site Not Available

  • Seton Cancer Institute at Saint Mary's - Saginaw

    Saginaw, Michigan 48601
    United States

    Site Not Available

  • Lakeland Regional Cancer Care Center - St. Joseph

    St. Joseph, Michigan 49085
    United States

    Site Not Available

  • Munson Medical Center

    Traverse City, Michigan 49684
    United States

    Site Not Available

  • St. John Macomb Hospital

    Warren, Michigan 48093
    United States

    Site Not Available

  • MeritCare Bemidji

    Bemidji, Minnesota 56601
    United States

    Site Not Available

  • Fairview Ridges Hospital

    Burnsville, Minnesota 55337
    United States

    Site Not Available

  • Mercy and Unity Cancer Center at Mercy Hospital

    Coon Rapids, Minnesota 55433
    United States

    Site Not Available

  • CCOP - Duluth

    Duluth, Minnesota 55805
    United States

    Site Not Available

  • Duluth Clinic Cancer Center - Duluth

    Duluth, Minnesota 55805-1983
    United States

    Site Not Available

  • Miller - Dwan Medical Center

    Duluth, Minnesota 55805
    United States

    Site Not Available

  • Fairview Southdale Hospital

    Edina, Minnesota 55435
    United States

    Site Not Available

  • Mercy and Unity Cancer Center at Unity Hospital

    Fridley, Minnesota 55432
    United States

    Site Not Available

  • Hutchinson Area Health Care

    Hutchinson, Minnesota 55350
    United States

    Site Not Available

  • Meeker County Memorial Hospital

    Lichfield, Minnesota 55355
    United States

    Site Not Available

  • HealthEast Cancer Care at St. John's Hospital

    Maplewood, Minnesota 55109
    United States

    Site Not Available

  • Minnesota Oncology Hematology, PA - Maplewood

    Maplewood, Minnesota 55109
    United States

    Site Not Available

  • Hennepin County Medical Center - Minneapolis

    Minneapolis, Minnesota 55415
    United States

    Site Not Available

  • Virginia Piper Cancer Institute at Abbott - Northwestern Hospital

    Minneapolis, Minnesota 55407
    United States

    Site Not Available

  • Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center

    Robbinsdale, Minnesota 55422-2900
    United States

    Site Not Available

  • CCOP - Metro-Minnesota

    Saint Louis Park, Minnesota 55416
    United States

    Site Not Available

  • St. Francis Cancer Center at St. Francis Medical Center

    Shakopee, Minnesota 55379
    United States

    Site Not Available

  • HealthEast Cancer Care at St. Joseph's Hospital

    St Paul, Minnesota 55102
    United States

    Site Not Available

  • Park Nicollet Cancer Center

    St. Louis Park, Minnesota 55416
    United States

    Site Not Available

  • Regions Hospital Cancer Care Center

    St. Paul, Minnesota 55101
    United States

    Site Not Available

  • United Hospital

    St. Paul, Minnesota 55102
    United States

    Site Not Available

  • Ridgeview Medical Center

    Waconia, Minnesota 55387
    United States

    Site Not Available

  • HealthEast Cancer Care at Woodwinds Health Campus

    Woodbury, Minnesota 55125
    United States

    Site Not Available

  • Minnesota Oncology Hematology, PA - Woodbury

    Woodbury, Minnesota 55125
    United States

    Site Not Available

  • CCOP - Kansas City

    Kansas City, Missouri 64131
    United States

    Site Not Available

  • Children's Mercy Hospital

    Kansas City, Missouri 64108
    United States

    Site Not Available

  • Billings Clinic - Downtown

    Billings, Montana 59107-7000
    United States

    Site Not Available

  • Billings Clinic Cancer Center

    Billings, Montana 59107-5100
    United States

    Site Not Available

  • CCOP - Montana Cancer Consortium

    Billings, Montana 59101
    United States

    Site Not Available

  • Hematology-Oncology Centers of the Northern Rockies - Billings

    Billings, Montana 59101
    United States

    Site Not Available

  • Northern Rockies Radiation Oncology Center

    Billings, Montana 59101
    United States

    Site Not Available

  • St. Vincent Healthcare Cancer Care Services

    Billings, Montana 59101
    United States

    Site Not Available

  • Bozeman Deaconess Cancer Center

    Bozeman, Montana 59715
    United States

    Site Not Available

  • St. James Healthcare Cancer Care

    Butte, Montana 59701
    United States

    Site Not Available

  • Big Sky Oncology

    Great Falls, Montana 59405-5309
    United States

    Site Not Available

  • Great Falls Clinic - Main Facility

    Great Falls, Montana 59405
    United States

    Site Not Available

  • Sletten Cancer Institute at Benefis Healthcare

    Great Falls, Montana 59405
    United States

    Site Not Available

  • Great Falls, Montana 59405
    United States

    Site Not Available

  • St. Peter's Hospital

    Helena, Montana 59601
    United States

    Site Not Available

  • Glacier Oncology, PLLC

    Kalispell, Montana 59901
    United States

    Site Not Available

  • Kalispell Medical Oncology at KRMC

    Kalispell, Montana 59901
    United States

    Site Not Available

  • Kalispell Regional Medical Center

    Kalispell, Montana 59901
    United States

    Site Not Available

  • Community Medical Center

    Missoula, Montana 59801
    United States

    Site Not Available

  • Guardian Oncology and Center for Wellness

    Missoula, Montana 59804
    United States

    Site Not Available

  • Montana Cancer Center at St. Patrick Hospital and Health Sciences Center

    Missoula, Montana 59807
    United States

    Site Not Available

  • Montana Cancer Specialists at Montana Cancer Center

    Missoula, Montana 59807-7877
    United States

    Site Not Available

  • Good Samaritan Cancer Center at Good Samaritan Hospital

    Kearney, Nebraska 68848-1990
    United States

    Site Not Available

  • Cancer Resource Center - Lincoln

    Lincoln, Nebraska 68510
    United States

    Site Not Available

  • CCOP - Missouri Valley Cancer Consortium

    Omaha, Nebraska 68106
    United States

    Site Not Available

  • Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center

    Lebanon, New Hampshire 03756-0002
    United States

    Site Not Available

  • Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton

    Marlton, New Jersey 08053
    United States

    Site Not Available

  • Booker Cancer Center at Riverview Medical Center

    Red Bank, New Jersey 07701
    United States

    Site Not Available

  • Cancer Institute of New Jersey at Cooper - Voorhees

    Voorhees, New Jersey 08043
    United States

    Site Not Available

  • Fox Chase Virtua Health Cancer Program at Virtua West Jersey

    Voorhees, New Jersey 08043
    United States

    Site Not Available

  • Lovelace Medical Center - Gibson

    Albuquerque, New Mexico 87108
    United States

    Site Not Available

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico 87131-5636
    United States

    Site Not Available

  • CCOP - Hematology-Oncology Associates of Central New York

    East Syracuse, New York 13057
    United States

    Site Not Available

  • Adirondack Cancer Care - Glens Falls

    Glens Falls, New York 12801
    United States

    Site Not Available

  • SUNY Upstate Medical University Hospital

    Syracuse, New York 13210
    United States

    Site Not Available

  • Presbyterian Cancer Center at Presbyterian Hospital

    Charlotte, North Carolina 28233-3549
    United States

    Site Not Available

  • Duke Comprehensive Cancer Center

    Durham, North Carolina 27710
    United States

    Site Not Available

  • Wayne Memorial Hospital, Incorporated

    Goldsboro, North Carolina 27534
    United States

    Site Not Available

  • CCOP - MeritCare Hospital

    Fargo, North Dakota 58122
    United States

    Site Not Available

  • MeritCare Broadway

    Fargo, North Dakota 58122
    United States

    Site Not Available

  • Mercy Cancer Center at Mercy Medical Center

    Canton, Ohio 44708
    United States

    Site Not Available

  • Adena Regional Medical Center

    Chillicothe, Ohio 45601
    United States

    Site Not Available

  • Charles M. Barrett Cancer Center at University Hospital

    Cincinnati, Ohio 45267
    United States

    Site Not Available

  • Cleveland Clinic Taussig Cancer Center

    Cleveland, Ohio 44195
    United States

    Site Not Available

  • MetroHealth Cancer Care Center at MetroHealth Medical Center

    Cleveland, Ohio 44109
    United States

    Site Not Available

  • Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center

    Columbus, Ohio 43210-1240
    United States

    Site Not Available

  • CCOP - Columbus

    Columbus, Ohio 43215
    United States

    Site Not Available

  • Doctors Hospital at Ohio Health

    Columbus, Ohio 43228
    United States

    Site Not Available

  • Grant Medical Center Cancer Care

    Columbus, Ohio 43215
    United States

    Site Not Available

  • Mount Carmel Health - West Hospital

    Columbus, Ohio 43222
    United States

    Site Not Available

  • Riverside Methodist Hospital Cancer Care

    Columbus, Ohio 43214-3998
    United States

    Site Not Available

  • Grady Memorial Hospital

    Delaware, Ohio 43015
    United States

    Site Not Available

  • Community Oncology Group at Cleveland Clinic Cancer Center

    Independence, Ohio 44131
    United States

    Site Not Available

  • Fairfield Medical Center

    Lancaster, Ohio 43130
    United States

    Site Not Available

  • St. Rita's Medical Center

    Lima, Ohio 45801
    United States

    Site Not Available

  • Strecker Cancer Center at Marietta Memorial Hospital

    Marietta, Ohio 45750
    United States

    Site Not Available

  • Licking Memorial Cancer Care Program at Licking Memorial Hospital

    Newark, Ohio 43055
    United States

    Site Not Available

  • Community Hospital of Springfield and Clark County

    Springfield, Ohio 45505
    United States

    Site Not Available

  • Mercy Medical Center

    Springfield, Ohio 45504
    United States

    Site Not Available

  • Mount Carmel St. Ann's Cancer Center

    Westerville, Ohio 43081
    United States

    Site Not Available

  • Cleveland Clinic - Wooster

    Wooster, Ohio 44691
    United States

    Site Not Available

  • Genesis - Good Samaritan Hospital

    Zanesville, Ohio 43701
    United States

    Site Not Available

  • Legacy Mount Hood Medical Center

    Gresham, Oregon 97030
    United States

    Site Not Available

  • Providence Milwaukie Hospital

    Milwaukie, Oregon 97222
    United States

    Site Not Available

  • Adventist Medical Center

    Portland, Oregon 97216
    United States

    Site Not Available

  • CCOP - Columbia River Oncology Program

    Portland, Oregon 97225
    United States

    Site Not Available

  • Legacy Emanuel Hospital and Health Center and Children's Hospital

    Portland, Oregon 97227
    United States

    Site Not Available

  • Legacy Good Samaritan Hospital & Comprehensive Cancer Center

    Portland, Oregon 97210
    United States

    Site Not Available

  • Providence Cancer Center at Providence Portland Medical Center

    Portland, Oregon 97213-2967
    United States

    Site Not Available

  • Providence St. Vincent Medical Center

    Portland, Oregon 97225
    United States

    Site Not Available

  • Salem Hospital Regional Cancer Care Services

    Salem, Oregon 97309-5014
    United States

    Site Not Available

  • Legacy Meridian Park Hospital

    Tualatin, Oregon 97062
    United States

    Site Not Available

  • Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest

    Allentown, Pennsylvania 18105
    United States

    Site Not Available

  • Geisinger Cancer Institute at Geisinger Health

    Danville, Pennsylvania 17822-0001
    United States

    Site Not Available

  • Penn State Cancer Institute at Milton S. Hershey Medical Center

    Hershey, Pennsylvania 17033-0850
    United States

    Site Not Available

  • Central Pennsylvania Hematology and Medical Oncology Associates, PC

    Lemoyne, Pennsylvania 17043
    United States

    Site Not Available

  • Lewistown Hospital

    Lewistown, Pennsylvania 17044
    United States

    Site Not Available

  • St. Christopher's Hospital for Children

    Philadelphia, Pennsylvania 19134-1095
    United States

    Site Not Available

  • UPMC Cancer Centers

    Pittsburgh, Pennsylvania 15232
    United States

    Site Not Available

  • Geisinger Medical Group - Scenery Park

    State College, Pennsylvania 16801
    United States

    Site Not Available

  • Mount Nittany Medical Center

    State College, Pennsylvania 16803
    United States

    Site Not Available

  • Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center

    Wilkes-Barre, Pennsylvania 18711
    United States

    Site Not Available

  • Roper St. Francis Cancer Center at Roper Hospital

    Charleston, South Carolina 29401
    United States

    Site Not Available

  • Palmetto Health South Carolina Cancer Center

    Columbia, South Carolina 29203
    United States

    Site Not Available

  • CCOP - Greenville

    Greenville, South Carolina 29615
    United States

    Site Not Available

  • Avera Cancer Institute

    Sioux Falls, South Dakota 57105
    United States

    Site Not Available

  • Medical X-Ray Center, PC

    Sioux Falls, South Dakota 57105
    United States

    Site Not Available

  • Sanford Cancer Center at Sanford USD Medical Center

    Sioux Falls, South Dakota 57117-5039
    United States

    Site Not Available

  • Thompson Cancer Survival Center

    Knoxville, Tennessee 37916
    United States

    Site Not Available

  • University of Tennessee Cancer Institute - Memphis

    Memphis, Tennessee 38104
    United States

    Site Not Available

  • Vanderbilt-Ingram Cancer Center

    Nashville, Tennessee 37232-6838
    United States

    Site Not Available

  • Harrington Cancer Center

    Amarillo, Texas 79106
    United States

    Site Not Available

  • Brooke Army Medical Center

    Fort Sam Houston, Texas 78234-6200
    United States

    Site Not Available

  • Cook Children's Medical Center - Fort Worth

    Fort Worth, Texas 76104
    United States

    Site Not Available

  • Wilford Hall Medical Center

    Lackland AFB, Texas 78236
    United States

    Site Not Available

  • University of Texas Health Science Center at San Antonio

    San Antonio, Texas 78207
    United States

    Site Not Available

  • CCOP - Scott and White Hospital

    Temple, Texas 76508
    United States

    Site Not Available

  • Huntsman Cancer Institute at University of Utah

    Salt Lake City, Utah 84112
    United States

    Site Not Available

  • Primary Children's Medical Center

    Salt Lake City, Utah 84113-1100
    United States

    Site Not Available

  • Martha Jefferson Hospital Cancer Care Center

    Charlottesville, Virginia 22901
    United States

    Site Not Available

  • Auburn Regional Center for Cancer Care

    Auburn, Washington 98002
    United States

    Site Not Available

  • St. Joseph Cancer Center

    Bellingham, Washington 98225
    United States

    Site Not Available

  • Olympic Hematology and Oncology

    Bremerton, Washington 98310
    United States

    Site Not Available

  • Providence Centralia Hospital

    Centralia, Washington 98531-9027
    United States

    Site Not Available

  • St. Francis Hospital

    Federal Way, Washington 98003
    United States

    Site Not Available

  • Skagit Valley Hospital Cancer Care Center

    Mt. Vernon, Washington 98273
    United States

    Site Not Available

  • Providence St. Peter Hospital Regional Cancer Center

    Olympia, Washington 98506-5166
    United States

    Site Not Available

  • Good Samaritan Cancer Center

    Puyallup, Washington 98372
    United States

    Site Not Available

  • Fred Hutchinson Cancer Research Center

    Seattle, Washington 98104
    United States

    Site Not Available

  • Group Health Central Hospital

    Seattle, Washington 98112
    United States

    Site Not Available

  • Harborview Medical Center

    Seattle, Washington 98104
    United States

    Site Not Available

  • Minor and James Medical, PLLC

    Seattle, Washington 98104
    United States

    Site Not Available

  • Polyclinic First Hill

    Seattle, Washington 98122
    United States

    Site Not Available

  • Swedish Cancer Institute at Swedish Medical Center - First Hill Campus

    Seattle, Washington 98122-4307
    United States

    Site Not Available

  • University Cancer Center at University of Washington Medical Center

    Seattle, Washington 98195-6043
    United States

    Site Not Available

  • Cancer Care Northwest - Spokane South

    Spokane, Washington 99202
    United States

    Site Not Available

  • Allenmore Hospital

    Tacoma, Washington 98405
    United States

    Site Not Available

  • CCOP - Northwest

    Tacoma, Washington 98405
    United States

    Site Not Available

  • Franciscan Cancer Center at St. Joseph Medical Center

    Tacoma, Washington 98405-3004
    United States

    Site Not Available

  • MultiCare Regional Cancer Center at Tacoma General Hospital

    Tacoma, Washington 98405
    United States

    Site Not Available

  • St. Clare Hospital

    Tacoma, Washington 98499
    United States

    Site Not Available

  • Southwest Washington Medical Center Cancer Center

    Vancouver, Washington 98668
    United States

    Site Not Available

  • Wenatchee Valley Medical Center

    Wenatchee, Washington 98801-2028
    United States

    Site Not Available

  • West Virginia University Health Sciences Center - Charleston

    Charleston, West Virginia 25304
    United States

    Site Not Available

  • Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital

    Parkersburg, West Virginia 26102
    United States

    Site Not Available

  • Fox Valley Hematology and Oncology - East Grant Street

    Appleton, Wisconsin 54911-3496
    United States

    Site Not Available

  • Green Bay Oncology, Limited at St. Mary's Hospital

    Green Bay, Wisconsin 54303
    United States

    Site Not Available

  • Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center

    Green Bay, Wisconsin 54301-3526
    United States

    Site Not Available

  • St. Mary's Hospital Medical Center - Green Bay

    Green Bay, Wisconsin 54303
    United States

    Site Not Available

  • St. Vincent Hospital Regional Cancer Center

    Green Bay, Wisconsin 54307-3508
    United States

    Site Not Available

  • Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center

    La Crosse, Wisconsin 54601
    United States

    Site Not Available

  • University of Wisconsin Paul P. Carbone Comprehensive Cancer Center

    Madison, Wisconsin 53792-6164
    United States

    Site Not Available

  • Bay Area Cancer Care Center at Bay Area Medical Center

    Marinette, Wisconsin 54143
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Oconto Falls

    Oconto Falls, Wisconsin 54154
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Sturgeon Bay

    Sturgeon Bay, Wisconsin 54235
    United States

    Site Not Available

  • Welch Cancer Center at Sheridan Memorial Hospital

    Sheridan, Wyoming 82801
    United States

    Site Not Available

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