Pexelizumab in Conjunction With Angioplasty in Acute Myocardial Infarction (APEX-AMI)

Inclusion Criteria:

• Cardiac symptoms for at least 20 minutes within past 6 hours;
• Will undergo primary PCI;
• Has ECG evidence of acute high risk ST elevation myocardial infarction;
• Willing and able to be followed for at least 12 months.

Exclusion Criteria:

• Isolated low risk inferior wall myocardial infarction;
• Received fibrinolytic therapy;
• History of complement deficiency;
• Suspected neisserial infection;
• Participating in other investigational study;
• Pregnancy;
• Previous enrollment.