Study of Escitalopram in Adult Patients With Major Depressive Disorder

Last updated: March 1, 2012
Sponsor: Forest Laboratories
Overall Status: Completed

Phase

3

Condition

Depression

Depression (Adult And Geriatric)

Depression (Major/severe)

Treatment

N/A

Clinical Study ID

NCT00108979
SCT-MD-23
  • Ages 18-80
  • All Genders

Study Summary

Escitalopram is the S-enantiomer of citalopram. Both escitalopram and citalopram are selective serotonin reuptake inhibitors (SSRIs) and are used to treat depression in adults. This study is designed to evaluate the efficacy, safety, and pharmacoeconomics of escitalopram and an active comparator in patients with major depressive disorder.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients must meet Diagnostic and Statistical Manual, Fourth Edition (DSM-IV)diagnostic criteria for Major Depressive Disorder.

  • The patient's current depressive episode must be at least 12 weeks in duration.

Exclusion

Exclusion Criteria:

  • Women who are pregnant, women who will be breastfeeding during the study, and women ofchildbearing potential who are not practicing a reliable method of birth control.

  • Patients who currently meet DSM-IV criteria for: a. bipolar disorder; b. schizophreniaor any psychotic disorder; c. obsessive-compulsive disorder; d. mental retardation orany pervasive developmental disorder or cognitive disorder.

  • Patients who are considered a suicide risk.

  • Patients with a history of seizure disorder, or any history of seizure, stroke,significant head injury, or any other condition that predisposes toward risk ofseizure.

Study Design

Total Participants: 240
Study Start date:
March 01, 2005
Estimated Completion Date:
July 31, 2006

Connect with a study center

  • Southwest Health, Ltd.

    Phoenix, Arizona 85016
    United States

    Site Not Available

  • Summit Research Network

    Okemos, Michigan 48864
    United States

    Site Not Available

  • University of Nebraska Medical Center

    Omaha, Nebraska 68198
    United States

    Site Not Available

  • Summit Research Network

    Portland, Oregon 97210
    United States

    Site Not Available

  • CNS Research Institute

    Philadelphia, Pennsylvania 19149
    United States

    Site Not Available

  • Clinical Neuroscience Solutions

    Memphis, Tennessee 38119
    United States

    Site Not Available

  • Radiant Research

    Salt Lake City, Utah 84107
    United States

    Site Not Available

  • Northwest Clinical Research Center

    Bellevue, Washington 98004
    United States

    Site Not Available

  • Summit Research Network

    Seattle, Washington 98104
    United States

    Site Not Available

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