Isavuconazole (BAL8557) in the Treatment of Candidemia and Other Invasive Candida Infections

Inclusion Criteria:

• Patients with candidemia or with an invasive Candida infection

• Presence of fever, hypothermia or other appropriate local sign of infection

• Female patients must be non-lactating and at no risk of pregnancy

Exclusion Criteria:

• Patients with a sole diagnosis of mucocutaneous candidiasis, i.e. oropharyngeal,esophageal or genital candidiasis; or candidal lower urinary tract infection orCandida isolated solely from respiratory tract specimens

• Patients with candidemia who failed a previous antifungal therapy for the sameinfection

• Patients previously enrolled in a phase III study with isavuconazole

• Patients with a body weight <40kg