Duloxetine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer

Last updated: March 16, 2017
Sponsor: Alliance for Clinical Trials in Oncology
Overall Status: Completed

Phase

3

Condition

Pain

Peripheral Neuropathy

Neurologic Disorders

Treatment

N/A

Clinical Study ID

NCT00489411
CALGB-170601
CDR0000553389
CALGB-170601
  • Ages > 25
  • All Genders

Study Summary

RATIONALE: Duloxetine may lessen peripheral neuropathy caused by chemotherapy. It is not yet known whether duloxetine is more effective than a placebo in treating peripheral neuropathy caused by chemotherapy.

PURPOSE: This randomized phase III trial is studying duloxetine to see how well it works compared with a placebo in treating peripheral neuropathy caused by chemotherapy in patients with cancer.

Eligibility Criteria

Inclusion

DISEASE CHARACTERISTICS:

  • Diagnosis of cancer

  • CNS malignancy allowed with the exception of leptomeningeal carcinomatosis

  • Must have painful sensory chemotherapy-induced peripheral neuropathy (CIPN) resulting from prior treatment with single-agent taxane or platinum agents (paclitaxel, docetaxel, nab-paclitaxel, oxaliplatin, cisplatin) (may not have received drugs from both classes)

  • CIPN > grade 1 as measured by NCI-CTCAE v 4.0

  • Average neuropathic pain score ≥ 4

  • Patients with the following illnesses known to cause peripheral neuropathy are eligible, provided they have no evidence of neuropathy from these illnesses:

  • Diabetes mellitus

  • Peripheral vascular disease

  • HIV infection

  • Significant degenerative or familial neurologic disorder known to cause peripheral neuropathy

  • No clinical or subclinical neuropathy from nerve compression injuries (i.e., carpal tunnel syndrome, brachial plexopathy, spinal stenosis, or spinal nerve root compression)

PATIENT CHARACTERISTICS:

  • AST ≤ 3 times upper limit of normal

  • Total bilirubin ≤ normal

  • Creatinine clearance > 30 mL/min

  • Not pregnant or nursing

  • Able to take oral or enteral medication

  • No history of seizure disorder

  • No diagnosis of ethanol addiction or dependence within the past 10 years

  • No history of narrow-angle glaucoma

  • None of the following:

  • History of suicidal thoughts

  • Symptoms of or history of schizophrenia, bipolar disease, or a major depression

  • Serious eating disorder such as bulimia or anorexia where electrolyte imbalance is likely

PRIOR CONCURRENT THERAPY:

  • At least 3 months since prior and no concurrent taxane or platinum agent

  • At least 14 days since prior and no concurrent monoamine oxidase inhibitors or other antidepressants

  • No other prior or concurrent neurotoxic drugs (e.g., vincristine, vinblastine, cytarabine, thalidomide, bortezomib, carboplatin, or procarbazine)

  • No concurrent anticonvulsants

  • No concurrent B or E vitamin supplementation in doses greater than the recommended daily allowance (RDA)

  • Centrum (standard formula) and One-A-Day "essential" formula which contain 100% RDA for vitamins B6, E, and B12 allowed

  • Other multivitamins allowed provided they contain no more than 100% RDA of B vitamins and vitamin E

  • No concurrent treatment (pharmacologic) for depression

Study Design

Total Participants: 231
Study Start date:
April 01, 2008
Estimated Completion Date:
March 31, 2013

Study Description

OBJECTIVES:

Primary

  • Determine the efficacy of duloxetine hydrochloride in cancer patients with painful chemotherapy-induced (taxane or platinum agent) peripheral neuropathy.

Secondary

  • Determine the influence of this drug on peripheral neuropathy-related functional status and quality of life of these patients.

  • Describe the differences in duloxetine hydrochloride efficacy when used to treat pain caused by chemotherapy-induced peripheral neuropathy based on the neurotoxic drug and class.

OUTLINE: This is a randomized, double-blind, placebo-controlled, crossover study. Patients are stratified according to prior neurotoxic agent (paclitaxel vs oxaliplatin vs other taxane agents without paclitaxel vs platinum agents [cisplatin] without oxaliplatin) and high risk for developing painful chemotherapy-induced peripheral neuropathy (no vs yes). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients receive oral duloxetine hydrochloride once or twice daily in weeks 1-6. After a 1-week rest period, patients cross over to receive an oral placebo once or twice daily in weeks 8-13.

  • Arm II: Patients receive an oral placebo once or twice daily in weeks 1-6. After a 1-week rest period, patients cross over to receive oral duloxetine hydrochloride once or twice daily in weeks 8-13.

Patients complete pain and quality of life questionnaires, including the BPI-SF once weekly and FACT/GOG-NTX and EORTC QLQ-C30 questionnaires, in weeks 1, 6, 8, and 13.

After completion of study treatment, patients are followed for 2 weeks.

Connect with a study center

  • Kaiser Permanente - Deer Valley

    Antioch, California 94531
    United States

    Site Not Available

  • Alta Bates Summit Comprehensive Cancer Center

    Berkeley, California 94704
    United States

    Site Not Available

  • Peninsula Medical Center

    Burlingame, California 94010
    United States

    Site Not Available

  • East Bay Radiation Oncology Center

    Castro Valley, California 94546
    United States

    Site Not Available

  • Valley Medical Oncology Consultants - Castro Valley

    Castro Valley, California 94546
    United States

    Site Not Available

  • Cancer Care Center at John Muir Health - Concord Campus

    Concord, California 94524-4110
    United States

    Site Not Available

  • Kaiser Permanente - Fremont

    Fremont, California 94538
    United States

    Site Not Available

  • Valley Medical Oncology

    Fremont, California 94538
    United States

    Site Not Available

  • Glendale Memorial Hospital Comprehensive Cancer Center

    Glendale, California 91204
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Hayward

    Hayward, California 94545
    United States

    Site Not Available

  • Rebecca and John Moores UCSD Cancer Center

    La Jolla, California 92093-0658
    United States

    Site Not Available

  • USC/Norris Comprehensive Cancer Center and Hospital

    Los Angeles, California 90089-9181
    United States

    Site Not Available

  • Contra Costa Regional Medical Center

    Martinez, California 94553-3156
    United States

    Site Not Available

  • Camino Medical Group - Treatment Center

    Mountain View, California 94040
    United States

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    Mountain View, California 94040
    United States

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    Oakland, California 94609
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    Oakland, California 94611
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    Oakland, California 94611
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    Oakland, California 94609
    United States

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    Oakland, California 94609
    United States

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    Palo Alto, California 94301
    United States

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    United States

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    Rancho Cardova, California 95670
    United States

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    Redwood City, California 94063
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    Richmond, California 94801
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    Rohnert Park, California 94928
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    Roseville, California 95661
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    Roseville, California 95661
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    Sacramento, California 95825
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    Colorado Springs, Colorado 80933
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    Denver, Colorado 80210
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    Fort Collins, Colorado 80528
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    Greenwich, Connecticut 06830
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    Hartford, Connecticut 06105
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    Newark, Delaware 19713
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    Washington, District of Columbia 20007
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  • Walter Reed Army Medical Center

    Washington, District of Columbia 20307-5001
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    Fort Lauderdale, Florida 33308
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    Hollywood, Florida 33021
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    Jupiter, Florida 33458
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    Lakeland, Florida 33805
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    Miami Beach, Florida 33140
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    Orlando, Florida 32803-1273
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    Weston, Florida 33331
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    Atlanta, Georgia 30342
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    Atlanta, Georgia 30342-1611
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    Atlanta, Georgia 30309
    United States

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    Atlanta, Georgia 30342-1701
    United States

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    Austell, Georgia 30106
    United States

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  • John B. Amos Cancer Center

    Columbus, Georgia 31904
    United States

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  • Charles B. Eberhart Cancer Center at DeKalb Medical Center

    Decatur, Georgia 30033
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  • Northeast Georgia Medical Center

    Gainesville, Georgia 30501
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  • Gwinnett Medical Center

    Lawrenceville, Georgia 30045
    United States

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  • Kennestone Cancer Center at Wellstar Kennestone Hospital

    Marietta, Georgia 30060
    United States

    Site Not Available

  • Southern Regional Medical Center

    Riverdale, Georgia 30274-2600
    United States

    Site Not Available

  • Harbin Clinic Cancer Center - Medical Oncology

    Rome, Georgia 30165
    United States

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  • Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler

    Savannah, Georgia 31405
    United States

    Site Not Available

  • Kaiser Permanente - Moanalua Medical Center and Clinic

    Honolulu, Hawaii 96819
    United States

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  • Saint Anthony's Hospital at Saint Anthony's Health Center

    Alton, Illinois 62002
    United States

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  • Rush-Copley Cancer Care Center

    Aurora, Illinois 60504
    United States

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  • Illinois CancerCare - Bloomington

    Bloomington, Illinois 61701
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    Bloomington, Illinois 61701
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    Bloomington%, Illinois 61701
    United States

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  • Graham Hospital

    Canton, Illinois 61520
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    Canton, Illinois 61520
    United States

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    Carthage, Illinois 62321
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    Carthage, Illinois 62321
    United States

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    Chicago, Illinois 60612-3785
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  • Resurrection Medical Center

    Chicago, Illinois 60631
    United States

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  • University of Chicago Cancer Research Center

    Chicago, Illinois 60637-1470
    United States

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    Decatur, Illinois 62526
    United States

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  • Elmhurst Memorial Hospital

    Elmhurst, Illinois 60126
    United States

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    Eureka, Illinois 61530
    United States

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  • Illinois CancerCare - Eureka

    Eureka, Illinois 61530
    United States

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  • Galesburg Clinic, PC

    Galesburg, Illinois 61401
    United States

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  • Illinois CancerCare - Galesburg

    Galesburg, Illinois 61401
    United States

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  • Illinois CancerCare - Havana

    Havana, Illinois 62644
    United States

    Site Not Available

  • Mason District Hospital

    Havana, Illinois 62644
    United States

    Site Not Available

  • Joliet Oncology-Hematology Associates, Limited - West

    Joliet, Illinois 60435
    United States

    Site Not Available

  • Illinois CancerCare - Kewanee Clinic

    Kewanee, Illinois 61443
    United States

    Site Not Available

  • La Grange Memorial Hospital

    La Grange, Illinois 60525
    United States

    Site Not Available

  • Illinois CancerCare - Macomb

    Macomb, Illinois 61455
    United States

    Site Not Available

  • McDonough District Hospital

    Macomb, Illinois 61455
    United States

    Site Not Available

  • Cardinal Bernardin Cancer Center at Loyola University Medical Center

    Maywood, Illinois 60153
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    Site Not Available

  • Trinity Cancer Center at Trinity Medical Center - 7th Street Campus

    Moline, Illinois 61265
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  • Moline, Illinois 61265
    United States

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  • Illinois CancerCare - Monmouth

    Monmouth, Illinois 61462
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  • OSF Holy Family Medical Center

    Monmouth, Illinois 61462
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  • Good Samaritan Regional Health Center

    Mount Vernon, Illinois 62864
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  • BroMenn Regional Medical Center

    Normal, Illinois 61761
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  • Community Cancer Center

    Normal, Illinois 61761
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  • Illinois CancerCare - Community Cancer Center

    Normal, Illinois 61761
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  • Community Hospital of Ottawa

    Ottawa, Illinois 61350
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  • Oncology Hematology Associates of Central Illinois, PC - Ottawa

    Ottawa, Illinois 61350
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  • Cancer Treatment Center at Pekin Hospital

    Pekin, Illinois 61554
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  • Illinois CancerCare - Pekin

    Pekin, Illinois 61603
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  • CCOP - Illinois Oncology Research Association

    Peoria, Illinois 61615
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  • Methodist Medical Center of Illinois

    Peoria, Illinois 61636
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  • OSF St. Francis Medical Center

    Peoria, Illinois 61637
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  • Oncology Hematology Associates of Central Illinois, PC - Peoria

    Peoria, Illinois 61615
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  • Proctor Hospital

    Peoria, Illinois 61614
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  • Illinois CancerCare - Peru

    Peru, Illinois 61354
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    Peru, Illinois 61354
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    Princeton, Illinois 61356
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    Princeton, Illinois 61356
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    Rockford, Illinois 61104-2315
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    Spring Valley, Illinois 61362
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    Springfield, Illinois 62781-0001
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    Urbana, Illinois 61801
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    Warrenville, Illinois 60555
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    Beech Grove, Indiana 46107
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    Elkhart, Indiana 46514-2098
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    Elkhart, Indiana 46515
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    Elkhart, Indiana 46514
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    Kokomo, Indiana 46904
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    La Porte, Indiana 46350
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    Michigan City, Indiana 46360
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    Mishawaka, Indiana 46545-1470
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    Mishawaka, Indiana 46545-1470
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    Plymouth, Indiana 46563
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    Richmond, Indiana 47374
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    South Bend, Indiana 46601
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    South Bend, Indiana 46601
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    South Bend, Indiana 46617
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    Westville, Indiana 46391
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    Ames, Iowa 50010
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    Cedar Rapids, Iowa 52403
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    Cedar Rapids, Iowa 52402
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    Sioux City, Iowa 51101
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    Chanute, Kansas 66720
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    Salina, Kansas 67401
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    Adrian, Michigan 49221
    United States

    Site Not Available

  • CCOP - Michigan Cancer Research Consortium

    Ann Arbor, Michigan 48106
    United States

    Site Not Available

  • Saint Joseph Mercy Cancer Center

    Ann Arbor, Michigan 48106-0995
    United States

    Site Not Available

  • Oakwood Cancer Center at Oakwood Hospital and Medical Center

    Dearborn, Michigan 48123-2500
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Escanaba

    Escanaba, Michigan 49431
    United States

    Site Not Available

  • Genesys Hurley Cancer Institute

    Flint, Michigan 48503
    United States

    Site Not Available

  • Great Lakes Cancer Institute at McLaren Regional Medical Center

    Flint, Michigan 48532
    United States

    Site Not Available

  • Hurley Medical Center

    Flint, Michigan 48503
    United States

    Site Not Available

  • Van Elslander Cancer Center at St. John Hospital and Medical Center

    Grosse Pointe Woods, Michigan 48236
    United States

    Site Not Available

  • Dickinson County Healthcare System

    Iron Mountain, Michigan 49801
    United States

    Site Not Available

  • Foote Memorial Hospital

    Jackson, Michigan 49201
    United States

    Site Not Available

  • Borgess Medical Center

    Kalamazoo, Michigan 49001
    United States

    Site Not Available

  • Bronson Methodist Hospital

    Kalamazoo, Michigan 49007
    United States

    Site Not Available

  • West Michigan Cancer Center

    Kalamazoo, Michigan 49007-3731
    United States

    Site Not Available

  • Haematology-Oncology Associates of Ohio and Michigan, PC

    Lambertville, Michigan 48144
    United States

    Site Not Available

  • Breslin Cancer Center at Ingham Regional Medical Center

    Lansing, Michigan 48910
    United States

    Site Not Available

  • Sparrow Regional Cancer Center

    Lansing, Michigan 48912-1811
    United States

    Site Not Available

  • St. Mary Mercy Hospital

    Livonia, Michigan 48154
    United States

    Site Not Available

  • Community Cancer Center of Monroe

    Monroe, Michigan 48162
    United States

    Site Not Available

  • Mercy Memorial Hospital - Monroe

    Monroe, Michigan 48162
    United States

    Site Not Available

  • Michiana Hematology Oncology PC - Niles

    Niles, Michigan 49120
    United States

    Site Not Available

  • St. Joseph Mercy Oakland

    Pontiac, Michigan 48341-2985
    United States

    Site Not Available

  • Mercy Regional Cancer Center at Mercy Hospital

    Port Huron, Michigan 48060
    United States

    Site Not Available

  • William Beaumont Hospital - Royal Oak Campus

    Royal Oak, Michigan 48073
    United States

    Site Not Available

  • Seton Cancer Institute at Saint Mary's - Saginaw

    Saginaw, Michigan 48601
    United States

    Site Not Available

  • Lakeside Cancer Specialists, PLLC

    Saint Joseph, Michigan 49085
    United States

    Site Not Available

  • Lakeland Regional Cancer Care Center - St. Joseph

    St. Joseph, Michigan 49085
    United States

    Site Not Available

  • St. John Macomb Hospital

    Warren, Michigan 48093
    United States

    Site Not Available

  • MeritCare Bemidji

    Bemidji, Minnesota 56601
    United States

    Site Not Available

  • Fairview Ridges Hospital

    Burnsville, Minnesota 55337
    United States

    Site Not Available

  • Mercy and Unity Cancer Center at Mercy Hospital

    Coon Rapids, Minnesota 55433
    United States

    Site Not Available

  • CCOP - Duluth

    Duluth, Minnesota 55805
    United States

    Site Not Available

  • Duluth Clinic Cancer Center - Duluth

    Duluth, Minnesota 55805-1983
    United States

    Site Not Available

  • Miller - Dwan Medical Center

    Duluth, Minnesota 55805
    United States

    Site Not Available

  • St. Luke's Hospital Cancer Care Center

    Duluth, Minnesota 55805
    United States

    Site Not Available

  • Fairview Southdale Hospital

    Edina, Minnesota 55435
    United States

    Site Not Available

  • Fergus Falls Medical Group, PA

    Fergus Falls, Minnesota 56537
    United States

    Site Not Available

  • Mercy and Unity Cancer Center at Unity Hospital

    Fridley, Minnesota 55432
    United States

    Site Not Available

  • Hutchinson Area Health Care

    Hutchinson, Minnesota 55350
    United States

    Site Not Available

  • HealthEast Cancer Care at St. John's Hospital

    Maplewood, Minnesota 55109
    United States

    Site Not Available

  • Minnesota Oncology Hematology, PA - Maplewood

    Maplewood, Minnesota 55109
    United States

    Site Not Available

  • Hennepin County Medical Center - Minneapolis

    Minneapolis, Minnesota 55415
    United States

    Site Not Available

  • Virginia Piper Cancer Institute at Abbott - Northwestern Hospital

    Minneapolis, Minnesota 55407
    United States

    Site Not Available

  • Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center

    Robbinsdale, Minnesota 55422-2900
    United States

    Site Not Available

  • CCOP - Metro-Minnesota

    Saint Louis Park, Minnesota 55416
    United States

    Site Not Available

  • Park Nicollet Cancer Center

    Saint Louis Park, Minnesota 55416
    United States

    Site Not Available

  • United Hospital

    Saint Paul, Minnesota 55102
    United States

    Site Not Available

  • St. Francis Cancer Center at St. Francis Medical Center

    Shakopee, Minnesota 55379
    United States

    Site Not Available

  • Regions Hospital Cancer Care Center

    St. Paul, Minnesota 55101
    United States

    Site Not Available

  • Ridgeview Medical Center

    Waconia, Minnesota 55387
    United States

    Site Not Available

  • Willmar Cancer Center at Rice Memorial Hospital

    Willmar, Minnesota 56201
    United States

    Site Not Available

  • Minnesota Oncology Hematology, PA - Woodbury

    Woodbury, Minnesota 55125
    United States

    Site Not Available

  • Saint Francis Medical Center

    Cape Girardeau, Missouri 63703
    United States

    Site Not Available

  • Saint Luke's Hospital

    Chesterfield, Missouri 63017
    United States

    Site Not Available

  • Ellis Fischel Cancer Center at University of Missouri - Columbia

    Columbia, Missouri 65203
    United States

    Site Not Available

  • Arch Medical Services, Incorporated at Center for Cancer Care and Research

    Saint Louis, Missouri 63141
    United States

    Site Not Available

  • CCOP - St. Louis-Cape Girardeau

    Saint Louis, Missouri 63141
    United States

    Site Not Available

  • Comprehensive Cancer Care, PC

    Saint Louis, Missouri 63141
    United States

    Site Not Available

  • David C. Pratt Cancer Center at St. John's Mercy

    Saint Louis, Missouri 63141
    United States

    Site Not Available

  • Midwest Hematology Oncology Group, Incorporated

    Saint Louis, Missouri 63109
    United States

    Site Not Available

  • Missouri Baptist Cancer Center

    Saint Louis, Missouri 63131
    United States

    Site Not Available

  • St. Anthony's Cancer Center

    Saint Louis, Missouri 63128
    United States

    Site Not Available

  • CCOP - Cancer Research for the Ozarks

    Springfield, Missouri 65802
    United States

    Site Not Available

  • Hulston Cancer Center at Cox Medical Center South

    Springfield, Missouri 65807
    United States

    Site Not Available

  • St. John's Regional Health Center

    Springfield, Missouri 65804
    United States

    Site Not Available

  • Billings Clinic - Downtown

    Billings, Montana 59107-7000
    United States

    Site Not Available

  • CCOP - Montana Cancer Consortium

    Billings, Montana 59101
    United States

    Site Not Available

  • Hematology-Oncology Centers of the Northern Rockies - Billings

    Billings, Montana 59102
    United States

    Site Not Available

  • Northern Rockies Radiation Oncology Center

    Billings, Montana 59101
    United States

    Site Not Available

  • St. Vincent Healthcare Cancer Care Services

    Billings, Montana 59101
    United States

    Site Not Available

  • Bozeman Deaconess Cancer Center

    Bozeman, Montana 59715
    United States

    Site Not Available

  • St. James Healthcare Cancer Care

    Butte, Montana 59701
    United States

    Site Not Available

  • Big Sky Oncology

    Great Falls, Montana 59405-5309
    United States

    Site Not Available

  • Great Falls Clinic - Main Facility

    Great Falls, Montana 59405
    United States

    Site Not Available

  • Sletten Cancer Institute at Benefis Healthcare

    Great Falls, Montana 59405
    United States

    Site Not Available

  • Northern Montana Hospital

    Havre, Montana 59501
    United States

    Site Not Available

  • St. Peter's Hospital

    Helena, Montana 59601
    United States

    Site Not Available

  • Glacier Oncology, PLLC

    Kalispell, Montana 59901
    United States

    Site Not Available

  • Kalispell Medical Oncology at KRMC

    Kalispell, Montana 59901
    United States

    Site Not Available

  • Kalispell Regional Medical Center

    Kalispell, Montana 59901
    United States

    Site Not Available

  • Montana Cancer Center at St. Patrick Hospital and Health Sciences Center

    Missoula, Montana 59807
    United States

    Site Not Available

  • Montana Cancer Specialists at Montana Cancer Center

    Missoula, Montana 59807-7877
    United States

    Site Not Available

  • Cancer Resource Center - Lincoln

    Lincoln, Nebraska 68510
    United States

    Site Not Available

  • Alegant Health Cancer Center at Bergan Mercy Medical Center

    Omaha, Nebraska 68124
    United States

    Site Not Available

  • CCOP - Missouri Valley Cancer Consortium

    Omaha, Nebraska 68106
    United States

    Site Not Available

  • Creighton University Medical Center

    Omaha, Nebraska 68131-2197
    United States

    Site Not Available

  • Immanuel Medical Center

    Omaha, Nebraska 68122
    United States

    Site Not Available

  • CCOP - Nevada Cancer Research Foundation

    Las Vegas, Nevada 89106
    United States

    Site Not Available

  • University Medical Center of Southern Nevada

    Las Vegas, Nevada 89102
    United States

    Site Not Available

  • New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care

    Concord, New Hampshire 03301
    United States

    Site Not Available

  • Center for Cancer Care at Exeter Hospital

    Exeter, New Hampshire 03833
    United States

    Site Not Available

  • New Hampshire Oncology - Hematology, PA - Hooksett

    Hooksett, New Hampshire 03106
    United States

    Site Not Available

  • Lakes Region General Hospital

    Laconia, New Hampshire 03246
    United States

    Site Not Available

  • Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center

    Lebanon, New Hampshire 03756-0002
    United States

    Site Not Available

  • Norris Cotton Cancer Center at Catholic Medical Center

    Manchester, New Hampshire 03102
    United States

    Site Not Available

  • Hunterdon Regional Cancer Center at Hunterdon Medical Center

    Flemington, New Jersey 08822
    United States

    Site Not Available

  • Saint Peter's University Hospital

    New Brunswick, New Jersey 08901
    United States

    Site Not Available

  • Somerset Medical Center

    Somerville, New Jersey 08876
    United States

    Site Not Available

  • Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare

    Vineland, New Jersey 08360
    United States

    Site Not Available

  • Cancer Institute of New Jersey at Cooper - Voorhees

    Voorhees, New Jersey 08043
    United States

    Site Not Available

  • New York Oncology Hematology, PC at Albany Medical Center

    Albany, New York 12208
    United States

    Site Not Available

  • New York Oncology Hematology, PC at Albany Regional Cancer Care

    Albany, New York 12206
    United States

    Site Not Available

  • Amsterdam Community Cancer Program

    Amsterdam, New York 12010
    United States

    Site Not Available

  • Veterans Affairs Medical Center - Brooklyn

    Brooklyn, New York 11209
    United States

    Site Not Available

  • CCOP - Hematology-Oncology Associates of Central New York

    East Syracuse, New York 13057
    United States

    Site Not Available

  • Charles R. Wood Cancer Center at Glens Falls Hospital

    Glens Falls, New York 12801
    United States

    Site Not Available

  • New York Oncology Hematology, PC - Hudson

    Hudson, New York 12534
    United States

    Site Not Available

  • Queens Cancer Center of Queens Hospital

    Jamaica, New York 11432
    United States

    Site Not Available

  • New York Oncology Hematology, PC - Latham

    Latham, New York 12110
    United States

    Site Not Available

  • Mount Sinai Medical Center

    New York, New York 10029
    United States

    Site Not Available

  • New York Weill Cornell Cancer Center at Cornell University

    New York, New York 10021
    United States

    Site Not Available

  • Riverview Cancer Care Medical Associates, PC

    Rexford, New York 12148
    United States

    Site Not Available

  • Nalitt Cancer Institute at Staten Island University Hospital

    Staten Island, New York 10305
    United States

    Site Not Available

  • Veterans Affairs Medical Center - Syracuse

    Syracuse, New York 13210
    United States

    Site Not Available

  • Samaritan Hospital at Northeast Health

    Troy, New York 12180
    United States

    Site Not Available

  • Dickstein Cancer Treatment Center at White Plains Hospital Center

    White Plains, New York 10601
    United States

    Site Not Available

  • Waverly Hematology Oncology

    Cary, North Carolina 27511
    United States

    Site Not Available

  • Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill

    Chapel Hill, North Carolina 27599-7295
    United States

    Site Not Available

  • Batte Cancer Center at Northeast Medical Center

    Concord, North Carolina 28025
    United States

    Site Not Available

  • CaroMont Cancer Center at Gaston Memorial Hospital

    Gastonia, North Carolina 28053
    United States

    Site Not Available

  • Wayne Memorial Hospital, Incorporated

    Goldsboro, North Carolina 27534
    United States

    Site Not Available

  • Pardee Memorial Hospital

    Hendersonville, North Carolina 28791
    United States

    Site Not Available

  • Emerywood Hematology/Oncology

    High Point, North Carolina 27262
    United States

    Site Not Available

  • High Point Regional Hospital

    High Point, North Carolina 27261
    United States

    Site Not Available

  • Kinston Medical Specialists

    Kinston, North Carolina 28501
    United States

    Site Not Available

  • Iredell Memorial Hospital

    Statesville, North Carolina 28677
    United States

    Site Not Available

  • Wake Forest University Comprehensive Cancer Center

    Winston-Salem, North Carolina 27157-1096
    United States

    Site Not Available

  • Bismarck Cancer Center

    Bismarck, North Dakota 58501
    United States

    Site Not Available

  • Medcenter One Hospital Cancer Care Center

    Bismarck, North Dakota 58501
    United States

    Site Not Available

  • Mid Dakota Clinic, PC

    Bismarck, North Dakota 58501
    United States

    Site Not Available

  • St. Alexius Medical Center Cancer Center

    Bismarck, North Dakota 58502
    United States

    Site Not Available

  • CCOP - MeritCare Hospital

    Fargo, North Dakota 58122
    United States

    Site Not Available

  • MeritCare Broadway

    Fargo, North Dakota 58122
    United States

    Site Not Available

  • Trinity CancerCare Center

    Minot, North Dakota 58701
    United States

    Site Not Available

  • McDowell Cancer Center at Akron General Medical Center

    Akron, Ohio 44307
    United States

    Site Not Available

  • Summa Center for Cancer Care at Akron City Hospital

    Akron, Ohio 44309-2090
    United States

    Site Not Available

  • Barberton Citizens Hospital

    Barberton, Ohio 44203
    United States

    Site Not Available

  • Mary Rutan Hospital

    Bellefontaine, Ohio 43311
    United States

    Site Not Available

  • Wood County Oncology Center

    Bowling Green, Ohio 43402
    United States

    Site Not Available

  • Aultman Cancer Center at Aultman Hospital

    Canton, Ohio 44710-1799
    United States

    Site Not Available

  • Adena Regional Medical Center

    Chillicothe, Ohio 45601
    United States

    Site Not Available

  • MetroHealth Cancer Care Center at MetroHealth Medical Center

    Cleveland, Ohio 44109
    United States

    Site Not Available

  • North Coast Cancer Care - Clyde

    Clyde, Ohio 43410
    United States

    Site Not Available

  • CCOP - Columbus

    Columbus, Ohio 43215
    United States

    Site Not Available

  • Doctors Hospital at Ohio Health

    Columbus, Ohio 43228
    United States

    Site Not Available

  • Grant Medical Center Cancer Care

    Columbus, Ohio 43215
    United States

    Site Not Available

  • Mount Carmel Health - West Hospital

    Columbus, Ohio 43222
    United States

    Site Not Available

  • Riverside Methodist Hospital Cancer Care

    Columbus, Ohio 43214-3998
    United States

    Site Not Available

  • CCOP - Dayton

    Dayton, Ohio 45420
    United States

    Site Not Available

  • David L. Rike Cancer Center at Miami Valley Hospital

    Dayton, Ohio 45409
    United States

    Site Not Available

  • Good Samaritan Hospital

    Dayton, Ohio 45406
    United States

    Site Not Available

  • Grandview Hospital

    Dayton, Ohio 45405
    United States

    Site Not Available

  • Samaritan North Cancer Care Center

    Dayton, Ohio 45415
    United States

    Site Not Available

  • Grady Memorial Hospital

    Delaware, Ohio 43015
    United States

    Site Not Available

  • Community Cancer Center

    Elyria, Ohio 44035
    United States

    Site Not Available

  • Hematology Oncology Center

    Elyria, Ohio 44035
    United States

    Site Not Available

  • Blanchard Valley Medical Associates

    Findlay, Ohio 45840
    United States

    Site Not Available

  • Middletown Regional Hospital

    Franklin, Ohio 45005-1066
    United States

    Site Not Available

  • Wayne Hospital

    Greenville, Ohio 45331
    United States

    Site Not Available

  • Charles F. Kettering Memorial Hospital

    Kettering, Ohio 45429
    United States

    Site Not Available

  • Fairfield Medical Center

    Lancaster, Ohio 43130
    United States

    Site Not Available

  • Lima Memorial Hospital

    Lima, Ohio 45804
    United States

    Site Not Available

  • St. Rita's Medical Center

    Lima, Ohio 45801
    United States

    Site Not Available

  • Strecker Cancer Center at Marietta Memorial Hospital

    Marietta, Ohio 45750
    United States

    Site Not Available

  • Northwest Ohio Oncology Center

    Maumee, Ohio 43537-1839
    United States

    Site Not Available

  • St. Luke's Hospital

    Maumee, Ohio 43537
    United States

    Site Not Available

  • Knox Community Hospital

    Mount Vernon, Ohio 43050
    United States

    Site Not Available

  • Licking Memorial Cancer Care Program at Licking Memorial Hospital

    Newark, Ohio 43055
    United States

    Site Not Available

  • Fisher-Titus Medical Center

    Norwalk, Ohio 44857
    United States

    Site Not Available

  • St. Charles Mercy Hospital

    Oregon, Ohio 43616
    United States

    Site Not Available

  • Toledo Clinic - Oregon

    Oregon, Ohio 43616
    United States

    Site Not Available

  • North Coast Cancer Care, Incorporated

    Sandusky, Ohio 44870
    United States

    Site Not Available

  • Community Hospital of Springfield and Clark County

    Springfield, Ohio 45505
    United States

    Site Not Available

  • Flower Hospital Cancer Center

    Sylvania, Ohio 43560
    United States

    Site Not Available

  • Mercy Hospital of Tiffin

    Tiffin, Ohio 44883
    United States

    Site Not Available

  • CCOP - Toledo Community Hospital

    Toledo, Ohio 43617
    United States

    Site Not Available

  • Medical University of Ohio Cancer Center

    Toledo, Ohio 43614
    United States

    Site Not Available

  • St. Anne Mercy Hospital

    Toledo, Ohio 43623
    United States

    Site Not Available

  • St. Vincent Mercy Medical Center

    Toledo, Ohio 43608
    United States

    Site Not Available

  • Toledo Clinic, Incorporated - Main Clinic

    Toledo, Ohio 43623
    United States

    Site Not Available

  • Toledo Hospital

    Toledo, Ohio 43606
    United States

    Site Not Available

  • UVMC Cancer Care Center at Upper Valley Medical Center

    Troy, Ohio 45373-1300
    United States

    Site Not Available

  • Fulton County Health Center

    Wauseon, Ohio 43567
    United States

    Site Not Available

  • Mount Carmel St. Ann's Cancer Center

    Westerville, Ohio 43081
    United States

    Site Not Available

  • United States Air Force Medical Center - Wright-Patterson

    Wright-Patterson Afb, Ohio 45433-5529
    United States

    Site Not Available

  • Ruth G. McMillan Cancer Center at Greene Memorial Hospital

    Xenia, Ohio 45385
    United States

    Site Not Available

  • Genesis - Good Samaritan Hospital

    Zanesville, Ohio 43701
    United States

    Site Not Available

  • Bay Area Hospital

    Coos Bay, Oregon 97420
    United States

    Site Not Available

  • Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest

    Allentown, Pennsylvania 18105
    United States

    Site Not Available

  • Bryn Mawr Hospital

    Bryn Mawr, Pennsylvania 19010
    United States

    Site Not Available

  • Geisinger Cancer Institute at Geisinger Health

    Danville, Pennsylvania 17822-0001
    United States

    Site Not Available

  • Doylestown Hospital Cancer Center

    Doylestown, Pennsylvania 18901
    United States

    Site Not Available

  • Delaware County Regional Cancer Center at Delaware County Memorial Hospital

    Drexel Hill, Pennsylvania 19026
    United States

    Site Not Available

  • Geisinger Hazleton Cancer Center

    Hazleton, Pennsylvania 18201
    United States

    Site Not Available

  • Cancer Center of Paoli Memorial Hospital

    Paoli, Pennsylvania 19301-1792
    United States

    Site Not Available

  • Cancer Center at Phoenixville Hospital

    Phoenixville, Pennsylvania 19460
    United States

    Site Not Available

  • Pottstown Memorial Regional Cancer Center

    Pottstown, Pennsylvania 19464
    United States

    Site Not Available

  • Geisinger Medical Group - Scenery Park

    State College, Pennsylvania 16801
    United States

    Site Not Available

  • Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center

    Wilkes-Barre, Pennsylvania 18711
    United States

    Site Not Available

  • CCOP - Main Line Health

    Wynnewood, Pennsylvania 19096
    United States

    Site Not Available

  • Lankenau Cancer Center at Lankenau Hospital

    Wynnewood, Pennsylvania 19096
    United States

    Site Not Available

  • Roper St. Francis Cancer Center at Roper Hospital

    Charleston, South Carolina 29401
    United States

    Site Not Available

  • McLeod Regional Medical Center

    Florence, South Carolina 29501
    United States

    Site Not Available

  • Bon Secours St. Francis Health System

    Greenville, South Carolina 29601
    United States

    Site Not Available

  • CCOP - Greenville

    Greenville, South Carolina 29615
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Faris Road

    Greenville, South Carolina 29605
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Grove Commons

    Greenville, South Carolina 29605
    United States

    Site Not Available

  • Greenville Hospital Cancer Center

    Greenville, South Carolina 29605
    United States

    Site Not Available

  • Self Regional Cancer Center at Self Regional Medical Center

    Greenwood, South Carolina 29646
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Greer Medical Oncology

    Greer, South Carolina 29650
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Seneca

    Seneca, South Carolina 29672
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Spartanburg

    Spartanburg, South Carolina 29307
    United States

    Site Not Available

  • Rapid City Regional Hospital

    Rapid City, South Dakota 57701
    United States

    Site Not Available

  • Brooke Army Medical Center

    Fort Sam Houston, Texas 78234-6200
    United States

    Site Not Available

  • Martha Jefferson Hospital Cancer Care Center

    Charlottesville, Virginia 22901
    United States

    Site Not Available

  • Danville Regional Medical Center

    Danville, Virginia 24541
    United States

    Site Not Available

  • Fredericksburg Oncology, Incorporated

    Fredericksburg, Virginia 22401
    United States

    Site Not Available

  • Ravenel Oncology Center at Memorial Hospital of Martinsville and Henry County

    Martinsville, Virginia 24115
    United States

    Site Not Available

  • Virginia Commonwealth University Massey Cancer Center

    Richmond, Virginia 23298-0037
    United States

    Site Not Available

  • Schiffler Cancer Center at Wheeling Hospital

    Wheeling, West Virginia 26003
    United States

    Site Not Available

  • Aurora Memorial Hospital of Burlington

    Burlington, Wisconsin 53105
    United States

    Site Not Available

  • Marshfield Clinic - Chippewa Center

    Chippewa Falls, Wisconsin 54729
    United States

    Site Not Available

  • Marshfield Clinic Cancer Care at Regional Cancer Center

    Eau Claire, Wisconsin 54701
    United States

    Site Not Available

  • Vince Lombardi Cancer Center at Aurora Lakeland Medical Center - Elkhorn

    Elkhorn, Wisconsin 53121
    United States

    Site Not Available

  • Oncology Alliance - Franklin

    Franklin, Wisconsin 53132
    United States

    Site Not Available

  • Oncology Alliance, SC - Milwaukee - East

    Glendale, Wisconsin 53212-1038
    United States

    Site Not Available

  • Green Bay Oncology, Limited at St. Mary's Hospital

    Green Bay, Wisconsin 54303
    United States

    Site Not Available

  • Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center

    Green Bay, Wisconsin 54301-3526
    United States

    Site Not Available

  • St. Mary's Hospital Medical Center - Green Bay

    Green Bay, Wisconsin 54303
    United States

    Site Not Available

  • St. Vincent Hospital Regional Cancer Center

    Green Bay, Wisconsin 54307-3508
    United States

    Site Not Available

  • Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center

    Green Bay, Wisconsin 54311
    United States

    Site Not Available

  • Mercy Regional Cancer Center

    Janesville, Wisconsin 53547
    United States

    Site Not Available

  • Oncology Alliance - Kenosha South

    Kenosha, Wisconsin 53143
    United States

    Site Not Available

  • Gundersen Lutheran Center for Cancer and Blood

    La Crosse, Wisconsin 54601
    United States

    Site Not Available

  • Dean Medical Center - Madison

    Madison, Wisconsin 53717
    United States

    Site Not Available

  • Holy Family Memorial Medical Center Cancer Care Center

    Manitowoc, Wisconsin 54221-1450
    United States

    Site Not Available

  • Bay Area Cancer Care Center at Bay Area Medical Center

    Marinette, Wisconsin 54143
    United States

    Site Not Available

  • Vince Lombardi Cancer Clinic - Marinette

    Marinette, Wisconsin 54143
    United States

    Site Not Available

  • Marshfield Clinic - Marshfield Center

    Marshfield, Wisconsin 54449
    United States

    Site Not Available

  • Aurora Advanced Healthcare East Mequon Clinic

    Mequon, Wisconsin 53092
    United States

    Site Not Available

  • Aurora Sinai Medical Center

    Milwaukee, Wisconsin 53201-0342
    United States

    Site Not Available

  • Medical Consultants, Limited

    Milwaukee, Wisconsin 53215
    United States

    Site Not Available

  • Oncology Alliance, SC - Milwaukee - South

    Milwaukee, Wisconsin 53215
    United States

    Site Not Available

  • Marshfield Clinic - Lakeland Center

    Minocqua, Wisconsin 54548
    United States

    Site Not Available

  • Regional Cancer Center at Oconomowoc Memorial Hospital

    Oconomowoc, Wisconsin 53066
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Oconto Falls

    Oconto Falls, Wisconsin 54154
    United States

    Site Not Available

  • Vince Lombardi Cancer Clinic - Oshkosh

    Oshkosh, Wisconsin 54904
    United States

    Site Not Available

  • Aurora Health Center - Racine

    Racine, Wisconsin 53406-5661
    United States

    Site Not Available

  • Ministry Medical Group at Saint Mary's Hospital

    Rhinelander, Wisconsin 54501
    United States

    Site Not Available

  • Marshfield Clinic - Indianhead Center

    Rice Lake, Wisconsin 54868
    United States

    Site Not Available

  • Vince Lombardi Cancer Clinic - Sheboygan

    Sheboygan, Wisconsin 53081
    United States

    Site Not Available

  • Marshfield Clinic at Saint Michael's Hospital

    Stevens Point, Wisconsin 54481
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Sturgeon Bay

    Sturgeon Bay, Wisconsin 54235
    United States

    Site Not Available

  • Aurora Medical Center

    Summit, Wisconsin 53066
    United States

    Site Not Available

  • Vince Lombardi Cancer Clinic - Two Rivers

    Two Rivers, Wisconsin 54241
    United States

    Site Not Available

  • Aurora Health Center - Waukesha

    Waukesha, Wisconsin 53188
    United States

    Site Not Available

  • Waukesha Memorial Hospital Regional Cancer Center

    Waukesha, Wisconsin 53188
    United States

    Site Not Available

  • Marshfield Clinic - Wausau Center

    Wausau, Wisconsin 54401
    United States

    Site Not Available

  • Oncology Alliance, SC - Milwaukee - West

    Wauwatosa, Wisconsin 53226
    United States

    Site Not Available

  • Aurora Women's Pavilion of West Allis Memorial Hospital

    West Allis, Wisconsin 53227
    United States

    Site Not Available

  • Marshfield Clinic - Weston Center

    Weston, Wisconsin 54476
    United States

    Site Not Available

  • Marshfield Clinic - Wisconsin Rapids Center

    Wisconsin Rapids, Wisconsin 54494
    United States

    Site Not Available

  • Rocky Mountain Oncology

    Casper, Wyoming 82609
    United States

    Site Not Available

  • Welch Cancer Center at Sheridan Memorial Hospital

    Sheridan, Wyoming 82801
    United States

    Site Not Available

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