Effects of Rosuvastatin on Aortic Stenosis Progression

Inclusion Criteria:

• Mild to moderate AS defined by peak Doppler aortic valve velocity 2.5 to 4 m/sec

• Baseline LDL-C value must be within targeted level for all risk categories accordingto the Canadian Guidelines

• Baseline triglyceride levels must be within target level for the risk categories

Exclusion Criteria:

• Very mild AS defined by peak Doppler AS velocity <2.5m/sec, because the rate ofprogression is not well defined; Females of child bearing potential who do notpractice adequate contraception.

• Severe AS defined by peak Doppler AS velocity > 4m/sec. These patients are excludedbecause they will have a high probability of aortic valve replacement even withoutfurther AS progression.

• Greater than moderate aortic regurgitation, defined as aortic jet width to aorticoutflow tract ratio >0.45; Patients with diabetes or with a fasting blood sugar level > 7.0 mmol/L (must be confirmed with one repeat assay within 14 days).

• Significant concomitant mitral valve disease, defined by > moderate mitralregurgitation (MR) or mitral valve area (MVA)< 1.5 cm2; A very high risk of CAD (10year risk > 30%), according to the Canadian Guidelines.