Reamer Irrigator Aspirator (RIA) vs Autogenous Iliac Crest Bone Graft (AICBG) for the Treatment of Non-unions

Last updated: November 25, 2019
Sponsor: St. Michael's Hospital, Toronto
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT01382485
RIA2011
  • Ages 18-65
  • All Genders

Study Summary

The specific question the investigators will seek to answer is: can the Reamer Irrigator Aspirator (RIA) provide a bone graft source for the treatment of nonunions that is equally effective to Autogenous Iliac Crest Bone Graft (AICBG) while resulting in a decreased amount of post-operative pain and a lower rate of complications?

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Subjects male or female, aged 18-65

  • Subjects with a nonunion of a long bone requiring bone grafting in the -opinion oftheir orthopaedic surgeon (nonunion will be defined as "9 months duration of thenonunited fracture with no evidence of progressive healing over the previous 3months")

  • Subjects must have an uninjured, healthy iliac crest and a femur that has notpreviously been operated on

  • Subjects must provide informed consent

Exclusion

Exclusion Criteria:

  • Subjects requiring a structural bone graft

  • Subjects presenting with an active systemic or local infection

  • Subjects with a nonunion due to pathologic fracture

  • Patients with severely compromised soft-tissue coverage at the nonunion site,sufficient to impair bone healing

  • Patients receiving radiation, chemotherapy, immunosuppression, or chronic steroids

  • Subjects with whom there are likely to be problems, in the judgment of theInvestigator or Research Coordinator, with maintaining follow-up (such as no fixedaddress, plans to move out of town in the next year, etc.).

Study Design

Total Participants: 104
Study Start date:
August 01, 2012
Estimated Completion Date:
August 31, 2021

Study Description

All subjects will be pre-screened by the treating physician. Subjects who present with a nonunion of a long bone will be invited to speak to the research coordinator regarding the study. An internet based randomization system will be used to allocate subjects to treatment groups. Participating sites will be given a unique ID and password to log into the secure website and register their subject.

Treating physicians will use 1 of 2 bone graft harvesting methods in patients with a nonunion of a long bone requiring grafting. The first method involves harvesting bone graft from the iliac crest area. The second method involves using the RIA to harvest bone graft from the femoral canal. Clinical assessments will occur at the time of hospital admission (baseline), at post-op day 1, and then at 2 weeks, 6 weeks, 3 months, 6 month, 12 months and 24 months post-surgery.

Surgical procedure at the nonunion site will not be standardized as this will vary greatly. Surgeons may use bone graft substitutes at the recipient site at their discretion. We will however, standardize surgical techniques for harvesting of the graft from the donor site.

Connect with a study center

  • St.Michael's Hospital

    Toronto, Ontario M5C 1R6
    Canada

    Active - Recruiting

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