Dose-comparison Study of Prednisone in Heart Failure

Last updated: August 27, 2013
Sponsor: Hebei Medical University
Overall Status: Completed

Phase

3

Condition

Heart Failure

Chest Pain

Congestive Heart Failure

Treatment

N/A

Clinical Study ID

NCT01559727
GL-2011-29
  • Ages 18-75
  • All Genders

Study Summary

The purpose of this study is to examine the efficacy of three doses of prednisone, a glucocorticoid, in treatment of patients with symptomatic heart failure.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • hospitalized for symptomatic heart failure

  • dyspnea at rest or with minimal activity

  • NT-proBNP > 1000pg/ml

  • LVEF ≤ 40%

Exclusion

Exclusion Criteria:

  • any condition (other than CHF) that could limit the use of prednisone;

  • acute decompensated heart failure

  • active myocarditis

  • obstructive or restrictive cardiomyopathy

  • cardiac surgery within previous 3 months

  • acute coronary syndrome

Study Design

Total Participants: 40
Study Start date:
March 01, 2012
Estimated Completion Date:
March 31, 2013

Study Description

Heart failure is a leading cause of cardiovascular morbidity and mortality in the world. Most patients with acute symptomatic heart failure are admitted with fluid overload. Intravenous loop diuretics are an essential component of current treatment in such patients. Newly emerging evidence showed that glucocorticoids could potentiate natriuretic peptides' action by upregulating the expression natriuretic peptide receptor A (NPR-A) in the kidney, and produce a potent diuresis. Therefore, the investigators designed this nonblinded, randomized dose comparison study to compare the efficacy of prednisone at 15, 30 and 60 mg/day in patients with in symptomatic heart failure.

Connect with a study center

  • The First Hospital of Hebei Medical University

    Shijiazhuang, Hebei 050031
    China

    Site Not Available

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