Ketamine Patient-Controlled Analgesia for Acute Pain

Last updated: August 21, 2017
Sponsor: University of Cincinnati
Overall Status: Terminated

Phase

3

Condition

Pain

Acute Pain

Treatment

N/A

Clinical Study ID

NCT02062879
Mueller2014
  • Ages > 18
  • All Genders

Study Summary

This study will compare ketamine and hydromorphone as alternative patient-controlled interventions for trauma-related pain. Patients receiving ketamine PCA are expected to require less total and breakthrough opioid and to have similar or improved objective pain scores. Patients receiving ketamine are also expected to have shorter duration of supplemental oxygen requirement, fewer episodes of oxygen desaturation, improved pulmonary toilet, lower use of antiemetics, and shorter times to first bowel movement. Ketamine is further expected to be associated with decreased intensive care unit and hospital lengths of stay, faster time to maximum allowable ambulation, decreased opioid dosage at discharge, and lower report of chronic pain syndromes.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age greater than or equal to 18 years

  • Total Injury Severity Score greater than 9

  • Functioning intravenous catheter present per standard of care

  • Patient planned to receive PCA for acute pain per standard of care

  • Patient ability to effectively use a PCA device as assessed by the primary attendingtrauma service

  • Negative pregnancy test for women of childbearing age

Exclusion

Exclusion Criteria:

  • Body mass index greater than 35

  • History of active psychiatric disease

  • Acute or chronic liver or renal failure

  • History of heart failure or coronary artery disease

  • Patients with documented chronic pain syndrome who use opioids as maintenancemedication in outpatient therapy

  • Patients who abuse alcohol and are at high risk for alcohol withdrawal

  • Intubated patients

  • Glasgow Coma Scale score less than 13, or motor subscore less than 6

  • Documented allergy to ketamine, hydromorphone, or lorazepam

  • Pregnancy

  • Incarceration

Study Design

Total Participants: 20
Study Start date:
April 01, 2014
Estimated Completion Date:
June 30, 2016

Connect with a study center

  • University of Cincinnati Medical Center

    Cincinnati, Ohio 45229
    United States

    Site Not Available

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