Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers

Last updated: October 16, 2024
Sponsor: Imperial College London
Overall Status: Active - Recruiting

Phase

N/A

Condition

Cancer

Treatment

Preoperative MRI scan

Clinical Study ID

NCT02222844
DOCUMAS: 23HH8201
  • Ages > 16
  • All Genders

Study Summary

Patients with suspected or proven sigmoid colon adenocarcinoma, eligible for curative treatment whose MRI can be reviewed prior to surgery and has no decision regarding radical treatment are eligible. Patient are randomised to the control arm which the standard care of preoperative CT imaging and subsequent discussion by the Multidisciplinary Team or the interventional arm which has the additional use of MRI imaging and subsequent discussion by the Multidisciplinary Team. Patients are followed up at 1 and 3 years together with QoL questionnaires.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Have a suspected or proven sigmoid colon adenocarcinoma

  2. Is eligible for curative treatment

  3. Has no irresectable metastatic disease

  4. MRI can be reviewed by an MDT prior to surgery

  5. Has no decision regarding radical treatment

  6. Have provided written informed consent to participate in the study

  7. Be aged 16 years or over

Exclusion

Exclusion Criteria:

  1. Have metastatic disease (including resectable liver metastases)

  2. Have a synchronous second malignancy

  3. Are contraindicated for MRI

  4. Are contraindicated for or have allergy to Buscopan (e.g. glaucoma, small or largebowel obstruction, GFR<30)

  5. Have severe co-morbidities or previous medical history that prevent the applicationof eventual chemo/radiotherapy

Study Design

Total Participants: 244
Treatment Group(s): 1
Primary Treatment: Preoperative MRI scan
Phase:
Study Start date:
August 01, 2014
Estimated Completion Date:
December 31, 2031

Study Description

A randomised phase II multicentre trial, IMPRESS will determine whether the use of MRI imaging in staging sigmoid cancers results in a change to the treatment plan by identifying more high risk tumours compared to those patients who were staged using CT imaging. The proposed intervention will be additional radiological and pathological assessment and the reporting of supplementary diagnostic information which would not otherwise have been available. This may affect treatment according to local MDT protocols and also affect the provision of prognostic information to patients in subsequent discussions.

Connect with a study center

  • Hinchingbrooke Hospital

    Huntingdon, Cambridgeshire PE29 6NT
    United Kingdom

    Active - Recruiting

  • Leighton Hospital

    Crewe, Cheshire CW1 4QJ
    United Kingdom

    Active - Recruiting

  • University Hospital of North Tees

    Stockton-on-Tees, County Durham TS19 8PE
    United Kingdom

    Active - Recruiting

  • Croydon University Hospital

    Thornton Heath, Croydon CR7 7YE
    United Kingdom

    Active - Recruiting

  • Chesterfield Royal

    Chesterfield, Derbyshire SS4 5BL
    United Kingdom

    Active - Recruiting

  • Queen Alexandra Hospital

    Portsmouth, Hampshire PO6 3LY
    United Kingdom

    Active - Recruiting

  • St Mark's Hospital

    Middlesex, Harrow HA1 3UJ
    United Kingdom

    Active - Recruiting

  • Hinchingbrooke Hospital

    Hinchingbrooke, Huntingdon PE29 6NT
    United Kingdom

    Site Not Available

  • Maidstone Hospital

    Maidstone, Kent ME16 9QQ
    United Kingdom

    Active - Recruiting

  • Queen Elizabeth the Queen Mother Hospital

    Margate, Kent CT9 4AN
    United Kingdom

    Active - Recruiting

  • North Manchester General Hospital

    Crumpsall, Manchester M8 5RB
    United Kingdom

    Active - Recruiting

  • University Hospital of South Manchester & Manchester Royal Infirmary

    Wythenshawe, Manchester M23 9LT
    United Kingdom

    Active - Recruiting

  • Harrogate District Hospital

    Harrogate, North Yorkshire HG2 7SX
    United Kingdom

    Active - Recruiting

  • Musgrove Park Hospital

    Taunton, Somerset TA1 5DA
    United Kingdom

    Active - Recruiting

  • Yeovil District Hospital

    Yeovil, Somerset BA21 4AT
    United Kingdom

    Site Not Available

  • Royal Marsden Hospital NHS Foundation Trust

    London/Surrey, Surrey SM2 5PT
    United Kingdom

    Site Not Available

  • Royal Marsden Hospital

    Sutton, Surrey SM2 5PT
    United Kingdom

    Active - Recruiting

  • Salisbury District Hospital

    Salisbury, Whiltshire SP2 8BJ
    United Kingdom

    Active - Recruiting

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