Study Comparing Daratumumab, Lenalidomide, and Dexamethasone With Lenalidomide and Dexamethasone in Participants With Previously Untreated Multiple Myeloma

Last updated: March 29, 2025
Sponsor: Janssen Research & Development, LLC
Overall Status: Completed

Phase

3

Condition

Multiple Myeloma

Bone Diseases

Lymphoproliferative Disorders

Treatment

Lenalidomide

Daratumumab IV

Dexamethasone

Clinical Study ID

NCT02252172
CR104762
2014-002273-11
54767414MMY3008
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to compare the efficacy of daratumumab in combination with lenalidomide and dexamethasone to that of lenalidomide and dexamethasone in terms of progression-free survival (PFS) in participants with newly diagnosed multiple myeloma (a blood cancer of plasma cells) who are not candidates for high dose chemotherapy (treatment of disease, usually cancer, by chemical agents) and autologous stem cell transplant (ASCT).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Participant must have documented multiple myeloma satisfying the CRAB (calciumelevation, renal insufficiency, anemia and bone abnormalities) criteria, monoclonalplasma cells in the bone marrow greater than or equal to (>=) 10 percent (%) orpresence of a biopsy proven plasmacytoma and measurable disease as defined by any ofthe following: (a) immunoglobulin (Ig) G myeloma (serum monoclonal paraprotein [M-protein] level >=1.0 gram/deciliter [g/dL] or urine M-protein level >=200milligram[mg]/24 hours[hrs]; or (b) IgA, IgM, IgD, or IgE multiple myeloma (serumM-protein level >=0.5 g/dL or urine M-protein level >=200 mg/24 hrs); or (c) lightchain multiple myeloma without measurable disease in serum or urine (serumimmunoglobulin free light chain >=10 mg/dL and abnormal serum immunoglobulin kappalambda free light chain ratio)

  • Participant must have an Eastern Cooperative Oncology Group (ECOG) performancestatus score of 0, 1, or 2

  • Participants who are newly diagnosed and not considered for high-dose chemotherapydue to: being age >=65 years; or participants less than (<) 65 years with presenceof important comorbid condition(s) likely to have a negative impact on tolerabilityof high dose chemotherapy with stem cell transplantation. Sponsor review andapproval of participants below 65 years of age is required before randomization

  • Women of childbearing potential must commit to either abstain continuously fromsexual intercourse or to use 2 methods of reliable birth control simultaneously asdeemed appropriate by the Investigator. Contraception must begin 4 weeks prior todosing and must continue for 3 months after the last dose of daratumumab

  • Man, who is sexually active with a woman of child-bearing potential must agree touse a latex or synthetic condom, even if he had a successful vasectomy, must agreeto use an adequate contraception method as deemed appropriate by the Investigator,and must also agree to not donate sperm during the study and for 4 weeks after lastdose of lenalidomide and 4 months after last dose of daratumumab

Exclusion

Exclusion Criteria:

  • Participant has a diagnosis of primary amyloidosis, monoclonal gammopathy ofundetermined significance (presence of serum M-protein <3 g/dL; absence of lyticbone lesions, anemia, hypercalcemia, and renal insufficiency related to theM-protein), or smoldering multiple myeloma (asymptomatic multiple myeloma withabsence of related organ or tissue impairment end organ damage)

  • Participant has a diagnosis of Waldenström's disease, or other conditions in whichIgM M protein is present in the absence of a clonal plasma cell infiltration withlytic bone lesions

  • Participant has a history of malignancy (other than multiple myeloma) within 5 yearsbefore the date of randomization (exceptions are squamous and basal cell carcinomasof the skin and carcinoma in situ of the cervix, or malignancy that in the opinionof the Investigator, with concurrence with the Sponsor's medical monitor, isconsidered cured with minimal risk of recurrence within 5 years)

  • Participant has prior or current systemic therapy or SCT for multiple myeloma, withthe exception of an emergency use of a short course (equivalent of dexamethasone 40mg/day for 4 days) of corticosteroids before treatment

  • Participant has had radiation therapy within 14 days of randomization

  • Participant has known chronic obstructive pulmonary disease (COPD) (defined as aforced expiratory volume in 1 second [FEV1] <50% of predicted normal), persistentasthma, or a history of asthma within the last 2 years (controlled intermittentasthma or controlled mild persistent asthma is allowed)

  • Participants with known or suspected COPD must have a FEV1 test during Screening

  • Participant is known to be seropositive for human immunodeficiency virus (HIV) orhepatitis B (defined by a positive test for hepatitis B surface antigen [HBsAg] orantibodies to hepatitis B surface and core antigens [anti-HBs and anti-HBc,respectively]) or hepatitis C (anti-HCV antibody positive or HCV-ribonucleic acid [RNA] quantitation positive)

Study Design

Total Participants: 737
Treatment Group(s): 4
Primary Treatment: Lenalidomide
Phase: 3
Study Start date:
February 16, 2015
Estimated Completion Date:
October 02, 2024

Study Description

This is a Phase 3, randomized (study drug assigned by chance), open-label (participants and researchers are aware about the treatment, participants are receiving), active-controlled (study in which the experimental treatment or procedure is compared to a standard treatment or procedure), parallel-group (each group of participants will be treated at the same time), and multicenter (when more than one hospital or medical school team work on a medical research study) study in participants with newly diagnosed multiple myeloma and who are not candidates for high dose chemotherapy and ASCT. All the eligible participants will be randomly assigned to receive either lenalidomide and dexamethasone (Rd) (Arm A) or daratumumab in combination with lenalidomide and dexamethasone (DRd) (Arm B). Daratumumab (16 milligram per kilogram [mg/kg]) will be administered weekly for first 8 weeks (Cycles 1 to 2) of treatment and then every other week for 16 weeks (Cycles 3 to 6), then every 4 weeks (from Cycle 7 and beyond) until progression of disease or unacceptable toxicity. Lenalidomide will be administered at a dose of 25 mg orally on Days 1 through 21 of each 28-day cycle, and dexamethasone will be administered at a dose of 40 mg once a week for both treatment arms. Participants in both treatment arms will continue lenalidomide and dexamethasone until disease progression or unacceptable toxicity. All participants randomized to Treatment Arm B (DRd) in this study initially received daratumumab IV formulation; however, following implementation of protocol amendment 8, participants still receiving treatment with daratumumab IV will have the option to switch to daratumumab SC on Day 1 of any cycle, at the discretion of the investigator. Daratumumab subcutaneous (SC) will be administered by SC injection at a fixed dose of 1800 mg once every 4 weeks until documented progression, unacceptable toxicity, or study completion. Participants in Arm A who have sponsor-confirmed disease progression may have the option to receive daratumumab provided by the sponsor (in any subsequent line of therapy) in the Follow-up phase. The study consists of 3 phases: Screening Phase (within 21 days prior to the first dose administration on Day 1), Treatment Phase (Day 1 up to discontinuation of all study treatment), and Follow-up Phase (from discontinuation of all study treatment up to death, lost to follow up, consent withdrawal, or study end, whichever occurs first). The maximum duration of study will be 7 years after last participant is randomized. Efficacy will primarily be evaluated by PFS. Participants' safety will be monitored throughout the study.

Connect with a study center

  • Box Hill Hospital

    Box Hill, 3128
    Australia

    Site Not Available

  • Box Hill,
    Australia

    Site Not Available

  • St. Vincent's Hospital Melbourne

    Fitzroy, 3065
    Australia

    Site Not Available

  • Fitzroy,
    Australia

    Site Not Available

  • Western Hospital

    Footscray, 3011
    Australia

    Site Not Available

  • Footscray,
    Australia

    Site Not Available

  • Austin Hospital

    Heidelberg, 3084
    Australia

    Site Not Available

  • St George Hospital

    Kogarah, 2217
    Australia

    Site Not Available

  • Kogarah,
    Australia

    Site Not Available

  • Ashford Cancer Centre

    Kurralta Park, 5037
    Australia

    Site Not Available

  • Kurralta Park,
    Australia

    Site Not Available

  • Nedlands,
    Australia

    Site Not Available

  • Calvary Mater Newcastle Hospital - Oncology Medical Centre

    New South Wales, 2298
    Australia

    Site Not Available

  • New South Wales,
    Australia

    Site Not Available

  • Perth Blood Institute

    Perth, 6009
    Australia

    Site Not Available

  • Queen Elizabeth Hospital

    Woodville, 5011
    Australia

    Site Not Available

  • Woodville,
    Australia

    Site Not Available

  • Princess Alexandra Hospital - Department of Haematology

    Woolloongabba N/A, 4102
    Australia

    Site Not Available

  • Woolloongabba N/a,
    Australia

    Site Not Available

  • Medizinische Universitatsklinik Innsbruck

    Innsbruck,
    Austria

    Site Not Available

  • Innsbruck,
    Austria

    Site Not Available

  • Krankenhaus der Elisabethinen Linz

    Linz, 4020
    Austria

    Site Not Available

  • Linz,
    Austria

    Site Not Available

  • Universitätsklinik für Innere Medizin - Austria

    Salzburg, 5020
    Austria

    Site Not Available

  • Salzburg,
    Austria

    Site Not Available

  • Hanusch Krankenhaus

    Wien N/A, 1140
    Austria

    Site Not Available

  • Wien N/a,
    Austria

    Site Not Available

  • AKH Wien, Klinik Für Innere Medizin I

    Wien Wien, 1090
    Austria

    Site Not Available

  • Wien Wien,
    Austria

    Site Not Available

  • AZ Sint-Jan Brugge-Oostende AV

    Brugge, 8000
    Belgium

    Site Not Available

  • Brugge,
    Belgium

    Site Not Available

  • Cliniques Universitaires St-Luc

    Brussel, 1200
    Belgium

    Site Not Available

  • Brussel,
    Belgium

    Site Not Available

  • Universitair Ziekenhuis Brussel

    Brussels, 1090
    Belgium

    Site Not Available

  • Brussels,
    Belgium

    Site Not Available

  • Haine Saint Paul La Louviere,
    Belgium

    Site Not Available

  • Hopital de Jolimont

    Haine-Saint-Paul, La Louviere, 7100
    Belgium

    Site Not Available

  • Haine-saint-paul, LA Louviere,
    Belgium

    Site Not Available

  • Universitaire Ziekenhuizen Leuven

    Leuven, 3000
    Belgium

    Site Not Available

  • Leuven,
    Belgium

    Site Not Available

  • Centre Hospitalier Universitaire de Liege Domaine Universitaire du Sart Tilman

    Liege, B-4000
    Belgium

    Site Not Available

  • Liege,
    Belgium

    Site Not Available

  • Foothills Hospital

    Calgary, Alberta T2N 2T9
    Canada

    Site Not Available

  • Calgary, Alberta
    Canada

    Site Not Available

  • Princess Margaret Hospital

    Toronto, Ontario M5G 2M9
    Canada

    Site Not Available

  • Toronto, Ontario
    Canada

    Site Not Available

  • Greenfield Park, Quebec
    Canada

    Site Not Available

  • Royal Victoria Hospital

    Montreal, Quebec H3A 1A1
    Canada

    Site Not Available

  • Montreal, Quebec
    Canada

    Site Not Available

  • Montréal, Quebec
    Canada

    Site Not Available

  • empty

    Montreal N/A,
    Canada

    Site Not Available

  • Cross Cancer Institute

    N/a N/a, T6G 1Z2
    Canada

    Site Not Available

  • N/a N/a,
    Canada

    Site Not Available

  • Capital Health

    Nova Scotia, B3H 2Y9
    Canada

    Site Not Available

  • Nova Scotia,
    Canada

    Site Not Available

  • Hopital Enfant-Jesus

    Quebec, G1J 1Z4
    Canada

    Site Not Available

  • Quebec,
    Canada

    Site Not Available

  • University of British Columbia (UBC)

    Vancouver, V5Z 1M9
    Canada

    Site Not Available

  • Aarhus University Hospital

    Aarhus C, 8000
    Denmark

    Site Not Available

  • Aarhus C,
    Denmark

    Site Not Available

  • Odense Universitetshospital

    Odense, 5000
    Denmark

    Site Not Available

  • Odense,
    Denmark

    Site Not Available

  • Vejle Sygehus

    Vejle, 7100
    Denmark

    Site Not Available

  • Vejle,
    Denmark

    Site Not Available

  • Chu Amiens Nord

    Amiens N/A Picardie, 80054
    France

    Site Not Available

  • Amiens N/a Picardie,
    France

    Site Not Available

  • CHU d'Angers

    Angers, 49933
    France

    Site Not Available

  • Angers,
    France

    Site Not Available

  • Centre Hospitalier de la Cote Basque

    Bayonne Cedex, 64109
    France

    Site Not Available

  • Bayonne Cedex,
    France

    Site Not Available

  • Ch Bretagne Atlantique De Vannes

    Bretagne, 56017
    France

    Site Not Available

  • Bretagne,
    France

    Site Not Available

  • Centre Hospitalier Universitaire (CHU) de Caen

    Caen, 14033
    France

    Site Not Available

  • Caen,
    France

    Site Not Available

  • CH René Dubos

    Cergy Pontoise, 95303
    France

    Site Not Available

  • Cergy Pontoise,
    France

    Site Not Available

  • Centre Hospitalier William Morey

    Chalons Sur Saone, 71100
    France

    Site Not Available

  • Chalons Sur Saone,
    France

    Site Not Available

  • CHU Estaing

    Clermont-Ferrand, 63003
    France

    Site Not Available

  • Clermont-Ferrand,
    France

    Site Not Available

  • HOPITAL HENRI MONDOR - Hematology

    Creteil, 94010
    France

    Site Not Available

  • Creteil,
    France

    Site Not Available

  • empty

    Creteil N/A,
    France

    Site Not Available

  • CHU Dijon - Hôpital Du Bocage

    Dijon, 21079
    France

    Site Not Available

  • Dijon,
    France

    Site Not Available

  • Centre Hospitalier de Dunkerque

    Dunkerque Cedex 1, 59385
    France

    Site Not Available

  • Dunkerque Cedex 1,
    France

    Site Not Available

  • C.H.U de Grenoble

    Grenoble Cedex 9, 38043
    France

    Site Not Available

  • Grenoble Cedex 9,
    France

    Site Not Available

  • Centre Hospitalier Départmental La Roche sur Yon

    La Roche Sur Yon Cedex 9, 85925
    France

    Site Not Available

  • La Roche sur Yon Cedex 9,
    France

    Site Not Available

  • Hopital Andre Mignot

    Le Chesnay Cedex, 78157
    France

    Site Not Available

  • Le Chesnay Cedex,
    France

    Site Not Available

  • CH de Chartres - Hôpital Louis Pasteur

    Le Coudray, 26630
    France

    Site Not Available

  • Centre Jean Bernard - Clinique Victor Hugo

    Le Mans, 72000
    France

    Site Not Available

  • Le Mans,
    France

    Site Not Available

  • GH de l'Institut Catholique Saint Vincent

    Lille, 59000
    France

    Site Not Available

  • Lille,
    France

    Site Not Available

  • Centre Hospitalier Régional Universitaire de Lille, Hôpital Claude Huriez

    Lille Cedex, 59000
    France

    Site Not Available

  • Lille Cedex,
    France

    Site Not Available

  • Chu Dupuytren

    Limoges, 87042
    France

    Site Not Available

  • Limoges,
    France

    Site Not Available

  • Centre Hospitalier de Bretagne

    Lorient, 56322
    France

    Site Not Available

  • Lyon,
    France

    Site Not Available

  • Centre Hospitalier Lyon-Sud Hematologie (HCL)

    Lyon, Pierre-Benite, 69495
    France

    Site Not Available

  • Lyon, Pierre-Benite,
    France

    Site Not Available

  • Institut Paoli Calmettes

    Marseille Cedex 9,
    France

    Site Not Available

  • Marseille Cedex 9,
    France

    Site Not Available

  • Centre Hospitalier Annecy Genevois

    Metz-Tessy, 74374
    France

    Site Not Available

  • Metz-Tessy,
    France

    Site Not Available

  • Centre Hospitalier du Havre

    Montivilliers, 76290
    France

    Site Not Available

  • Montivilliers,
    France

    Site Not Available

  • CHU de Montpellier - Hopital Saint-Eloi

    Montpellier, 34295
    France

    Site Not Available

  • Montpellier,
    France

    Site Not Available

  • Centre hospitalier de Mulhouse

    Mulhouse, 68070
    France

    Site Not Available

  • Mulhouse,
    France

    Site Not Available

  • Centre Catherine de Sienne

    Nantes, 44202
    France

    Site Not Available

  • Nantes,
    France

    Site Not Available

  • CHU HOPITAL DE L'ARCHET - Hematology

    Nice N/A, 06202
    France

    Site Not Available

  • Nice N/a,
    France

    Site Not Available

  • PERIGUEUX cedex,
    France

    Site Not Available

  • Groupe Hospitalier Pitie

    Paris, 75651
    France

    Site Not Available

  • Paris,
    France

    Site Not Available

  • Hopital Saint-Antoine

    Paris Cedex 12, 75571
    France

    Site Not Available

  • Paris Cedex 12,
    France

    Site Not Available

  • Hopital Cochin APHP

    Paris, 75, 75674
    France

    Site Not Available

  • Paris, 75,
    France

    Site Not Available

  • Centre Hospitalier de Perigueux

    Perigueux Cedex, 24019
    France

    Site Not Available

  • Centre Hospitalier De Perpignan - Hopital Marechal Joffre

    Perpignan, 66046
    France

    Site Not Available

  • Perpignan,
    France

    Site Not Available

  • CHU de Boreaux

    Pessac, 33604
    France

    Site Not Available

  • Pessac,
    France

    Site Not Available

  • CHU Poitiers - Hôpital la Milétrie

    Poitiers, 86021
    France

    Site Not Available

  • Poitiers,
    France

    Site Not Available

  • CHU Reims - Hôpital Robert Debré

    Reims, 51092
    France

    Site Not Available

  • Reims,
    France

    Site Not Available

  • empty

    Reims N/A,
    France

    Site Not Available

  • CHRU Hopital Sud

    Rennes, 35203
    France

    Site Not Available

  • Rennes,
    France

    Site Not Available

  • CLCC - Centre Henri Becquerel

    Rouen Cedex, 76038
    France

    Site Not Available

  • Rouen Cedex,
    France

    Site Not Available

  • Hôpital Yves Le Foll

    Saint Brieuc Cedex 1, 22027
    France

    Site Not Available

  • Saint Brieuc Cedex 1,
    France

    Site Not Available

  • Institut de Cancerologie Lucien Neuwirth

    Saint Priest En Jarez, 42271
    France

    Site Not Available

  • Saint Priest en Jarez,
    France

    Site Not Available

  • Hopital Broussais

    St Malo Cedex, 35403
    France

    Site Not Available

  • St Malo Cedex,
    France

    Site Not Available

  • Ch De St Quentin

    St Quentin Cedex, 02321
    France

    Site Not Available

  • St Quentin Cedex,
    France

    Site Not Available

  • Strasbourg,
    France

    Site Not Available

  • Hopital Hautepierre

    Strasbourg Cedex, 67098
    France

    Site Not Available

  • TOURS Cedex 9,
    France

    Site Not Available

  • Institut Universitaire du cancer de Toulouse-Oncopole

    Toulouse Cedex 9, 31059
    France

    Site Not Available

  • Toulouse Cedex 9,
    France

    Site Not Available

  • CHU de Tours - Hôpital de Bretonneau

    Tours Cedex 9, 37044
    France

    Site Not Available

  • CHU Nancy Brabois

    Vandoeuvre Les Nancy, 54511
    France

    Site Not Available

  • Vandoeuvre Les Nancy,
    France

    Site Not Available

  • Studienzentrale Hämatologie/Onkolgie/Diabetologie Aschaffenburg

    Aschaffenburg, 63739
    Germany

    Site Not Available

  • Aschaffenburg,
    Germany

    Site Not Available

  • Zentralklinik Bad Berka / Pneumologie - Germany

    Bad Berka, 99437
    Germany

    Site Not Available

  • Bad Berka,
    Germany

    Site Not Available

  • Klinikum Bamberg

    Bamberg, By, 96049
    Germany

    Site Not Available

  • Universitatskinikum Bonn Medizinische Klinik und Poliklinik III

    Bonn, 53105
    Germany

    Site Not Available

  • Bonn,
    Germany

    Site Not Available

  • Städtisches Krankenhaus Braunschweig - Abtlg. f. Hämatologie / Onkologie

    Braunschweig, 38114
    Germany

    Site Not Available

  • Braunschweig,
    Germany

    Site Not Available

  • Universitätsklinik Carl Gustav Carus, Med. Klinik u. Poliklinik I

    Dresden, 01307
    Germany

    Site Not Available

  • Dresden,
    Germany

    Site Not Available

  • Med. Universitätsklinik Essen

    Essen, 45147
    Germany

    Site Not Available

  • Essen,
    Germany

    Site Not Available

  • Universitaetsklinikum Frankfurt,

    Frankfurt, 60590
    Germany

    Site Not Available

  • Frankfurt,
    Germany

    Site Not Available

  • Klinikum Siloah - Oststadt-Heidehaus

    Hannover, 30459
    Germany

    Site Not Available

  • Hannover,
    Germany

    Site Not Available

  • Heidelberg,
    Germany

    Site Not Available

  • Universitaetskilinihum Giessen

    Hessen, 35392
    Germany

    Site Not Available

  • Hessen,
    Germany

    Site Not Available

  • Universitaetsklinikum Schleswig-Holstein Campus Kiel

    Kiel, 24105
    Germany

    Site Not Available

  • Kiel,
    Germany

    Site Not Available

  • Praxisklinik für Haematologie und Onkologie Koblenz

    Koblenz, 56068
    Germany

    Site Not Available

  • Koblenz,
    Germany

    Site Not Available

  • Universitaets-Medizin der Johann-Gutenberg-Unversitaet - III. Medizinische Klinik und Poliklinik

    Mainz, 55101
    Germany

    Site Not Available

  • Mainz,
    Germany

    Site Not Available

  • Mannheimer Onkologie Praxis

    Mannheim, 68161
    Germany

    Site Not Available

  • Mannheim,
    Germany

    Site Not Available

  • Universitätsklinik Rostock - Klinik u. Poliklinik f. Innere Medizin - Abtl. Hämatologie / Onkologi

    Rostock, 18057
    Germany

    Site Not Available

  • Rostock,
    Germany

    Site Not Available

  • Helios Kliniken Schwerin - Onkologie

    Schwerin, 19049
    Germany

    Site Not Available

  • Schwerin,
    Germany

    Site Not Available

  • Robert-Bosch-Krankenhaus - Hämatologie / Onkologie

    Stuttgart, 70376
    Germany

    Site Not Available

  • Stuttgart,
    Germany

    Site Not Available

  • Universitaetsklinikum Tuebingen

    Tuebingen, 72076
    Germany

    Site Not Available

  • Tuebingen,
    Germany

    Site Not Available

  • Universitaetsklinikum Ulm

    Ulm, 89081
    Germany

    Site Not Available

  • Ulm,
    Germany

    Site Not Available

  • Schwarzwald-Baar Klinikum, Klinik f. Hämatologie/Onkologie

    Villingen-Schwenningen, 78052
    Germany

    Site Not Available

  • Villingen-Schwenningen,
    Germany

    Site Not Available

  • Mater Misericordial Hospital - Haematology

    Dublin,
    Ireland

    Site Not Available

  • Dublin,
    Ireland

    Site Not Available

  • University Hospital Galway - Ireland

    Galway, H91 YR71
    Ireland

    Site Not Available

  • Galway,
    Ireland

    Site Not Available

  • empty

    Galway N/A,
    Ireland

    Site Not Available

  • Hematology

    Afula,
    Israel

    Site Not Available

  • The Barzilai Medical Center

    Ashkelon, 78306
    Israel

    Site Not Available

  • Hillel Yaffe Medical Center - Oncology

    Hadera, 38100
    Israel

    Site Not Available

  • Hadera,
    Israel

    Site Not Available

  • Rambam Medical Center

    Haifa, 31096
    Israel

    Site Not Available

  • Haifa,
    Israel

    Site Not Available

  • Hadassah Medical Organization

    Jerusalem,
    Israel

    Site Not Available

  • Jerusalem,
    Israel

    Site Not Available

  • Institute of Hematology

    Nahariya, 22100
    Israel

    Site Not Available

  • Nahariya,
    Israel

    Site Not Available

  • Rabin Medical Center, Beilinson Campus

    Petah Tikva, 49100
    Israel

    Site Not Available

  • Petah Tikva,
    Israel

    Site Not Available

  • Chaim Sheba Medical Center - Dept.of Oncology

    Ramat Gan, 52621
    Israel

    Site Not Available

  • Kaplan Medical Center

    Rehovot, 76100
    Israel

    Site Not Available

  • Tel-Aviv Sourasky Medical Center

    Tel-Aviv, 64239
    Israel

    Site Not Available

  • Tel-Aviv,
    Israel

    Site Not Available

  • Ziekenhuis Hilversum

    Hilversum, 1213XZ
    Netherlands

    Site Not Available

  • Hilversum,
    Netherlands

    Site Not Available

  • Spaarne Ziekenhuis

    Hoofddorp,
    Netherlands

    Site Not Available

  • Hoofddorp,
    Netherlands

    Site Not Available

  • Erasmus MC, Lok Daniel - Afd.Hematologie - HEM

    Rotterdam, 3075 EA
    Netherlands

    Site Not Available

  • Rotterdam,
    Netherlands

    Site Not Available

  • Tweestedenziekenhuis

    Tilburg, 5042 AD
    Netherlands

    Site Not Available

  • Tilburg,
    Netherlands

    Site Not Available

  • empty

    Auckland,
    New Zealand

    Site Not Available

  • empty

    Palmerston North,
    New Zealand

    Site Not Available

  • empty

    Wellington,
    New Zealand

    Site Not Available

  • Falu Lasarett, Medicinkliniken, Falun

    Falun, 791 82
    Sweden

    Site Not Available

  • Falun,
    Sweden

    Site Not Available

  • Sahlgrenska University Hospital

    Göteborg, 413 45
    Sweden

    Site Not Available

  • Göteborg,
    Sweden

    Site Not Available

  • Hallands Sjukhus

    Halmstad, 301 85
    Sweden

    Site Not Available

  • Halmstad,
    Sweden

    Site Not Available

  • Helsingborg Lasarett - Hematologi

    Helsingborg, 25187
    Sweden

    Site Not Available

  • Helsingborg,
    Sweden

    Site Not Available

  • Karolinska Universitetssjukhuset Huddinge, Hematologiska Kliniken, M54, Huddinge

    Huddinge, 141 86
    Sweden

    Site Not Available

  • Huddinge,
    Sweden

    Site Not Available

  • Sunderby Sjukhus, Medicinkliniken, 971 80 Luleå

    Lulea, 971 80
    Sweden

    Site Not Available

  • Lulea,
    Sweden

    Site Not Available

  • Lund University Hospital/Skåne

    Lund, 221 85
    Sweden

    Site Not Available

  • Lund,
    Sweden

    Site Not Available

  • Karolinska Universitetssjukhuset Solna, Centrum för Hematologi, Stockholm

    Stockholm, 171 76
    Sweden

    Site Not Available

  • Stockholm,
    Sweden

    Site Not Available

  • Universitetssjukhuset Örebro, Onkologiska Kliniken, Örebro

    Örebro, 701 85
    Sweden

    Site Not Available

  • Örebro,
    Sweden

    Site Not Available

  • Aberdeen Royal Infirmary

    Aberdeen, AB25 2ZB
    United Kingdom

    Site Not Available

  • Aberdeen,
    United Kingdom

    Site Not Available

  • Kent and Canterbury Hospital

    Canterbury, CT1 3NG
    United Kingdom

    Site Not Available

  • Canterbury,
    United Kingdom

    Site Not Available

  • Ninewells Hospital

    Dundee, DD5 9SY
    United Kingdom

    Site Not Available

  • Dundee,
    United Kingdom

    Site Not Available

  • St James Hospital

    Leeds, LS9 7TF
    United Kingdom

    Site Not Available

  • Leeds,
    United Kingdom

    Site Not Available

  • Barts and the London NHS Trust

    London, EC1A 7BE
    United Kingdom

    Site Not Available

  • London,
    United Kingdom

    Site Not Available

  • Christie Hospital

    Manchester, M20 4BX
    United Kingdom

    Site Not Available

  • Manchester,
    United Kingdom

    Site Not Available

  • Nottingham City Hospital

    Nottingham, NG5 1PB
    United Kingdom

    Site Not Available

  • Nottingham,
    United Kingdom

    Site Not Available

  • Oxford Cancer Centre Medical Oncology Unit, Churchill Hospital

    Oxford, OX3 7LJ
    United Kingdom

    Site Not Available

  • Oxford,
    United Kingdom

    Site Not Available

  • Plymouth,
    United Kingdom

    Site Not Available

  • Plymouth Hospitals NHS Trust - Hematology

    Plymouth, Devon,
    United Kingdom

    Site Not Available

  • Plymouth, Devon,
    United Kingdom

    Site Not Available

  • Southampton University Hospital

    Southampton, SO16 6YD
    United Kingdom

    Site Not Available

  • Southampton,
    United Kingdom

    Site Not Available

  • Royal Cornwall Hospital

    Truro, TR1 3LJ
    United Kingdom

    Site Not Available

  • Truro,
    United Kingdom

    Site Not Available

  • Pinderfields General Hospital - Dept. of Neurology

    Wf,
    United Kingdom

    Site Not Available

  • New Cross Hospital

    Wolverhampton,
    United Kingdom

    Site Not Available

  • Wolverhampton,
    United Kingdom

    Site Not Available

  • University of Alabama at Birmingham

    Birmingham, Alabama 35294
    United States

    Site Not Available

  • Birmingham, Alabama
    United States

    Site Not Available

  • Mitchell Cancer Institute

    Mobile, Alabama 36604
    United States

    Site Not Available

  • Mobile, Alabama
    United States

    Site Not Available

  • Palo Verde Hematology Oncology

    Glendale, Arizona 85304
    United States

    Site Not Available

  • Glendale, Arizona
    United States

    Site Not Available

  • Alta Bates Medical Center Cancer Center

    Berkeley, California 94704
    United States

    Site Not Available

  • Berkeley, California
    United States

    Site Not Available

  • Beverly Hills Cancer Center (BHCC)

    Beverly Hills, California 90211
    United States

    Site Not Available

  • Beverly Hills, California
    United States

    Site Not Available

  • TriWest Research Associates, LLC

    El Cajon, California 92020
    United States

    Site Not Available

  • El Cajon, California
    United States

    Site Not Available

  • California Cancer Care

    Greenbrae, California 94904
    United States

    Site Not Available

  • Greenbrae, California
    United States

    Site Not Available

  • Cedars-Sinai Medical Center

    Los Angeles, California 90048
    United States

    Site Not Available

  • Los Angeles, California
    United States

    Site Not Available

  • North County Oncology

    Oceanside, California 92056
    United States

    Site Not Available

  • Oceanside, California
    United States

    Site Not Available

  • Oncology Associates of San Diego

    San Diego, California 92123
    United States

    Site Not Available

  • San Diego, California
    United States

    Site Not Available

  • Coastal Integrative Cancer Care

    San Luis Obispo, California 93401
    United States

    Site Not Available

  • Wellness Hematology & Oncology

    West Hills, California 91307
    United States

    Site Not Available

  • West Hills, California
    United States

    Site Not Available

  • American Institute of Research (AIR)

    Whittier, California 90603
    United States

    Site Not Available

  • Whittier, California
    United States

    Site Not Available

  • Colorado Blood Cancer Institute

    Denver, Colorado 80218
    United States

    Site Not Available

  • Denver, Colorado
    United States

    Site Not Available

  • University of Colorado Health

    Fort Collins, Colorado 80528
    United States

    Site Not Available

  • Fort Collins, Colorado
    United States

    Site Not Available

  • Valley View Hospital-oncology

    Glenwood Springs, Colorado 81601
    United States

    Site Not Available

  • Glenwood Springs, Colorado
    United States

    Site Not Available

  • Yale University School of Medicine - Oncology

    New Haven, Connecticut 06520
    United States

    Site Not Available

  • New Haven, Connecticut
    United States

    Site Not Available

  • Norwalk Hospital-oncology

    Norwalk, Connecticut 06850
    United States

    Site Not Available

  • Norwalk, Connecticut
    United States

    Site Not Available

  • MedStar Georgetown University Hospital

    Washington, District of Columbia 20007
    United States

    Site Not Available

  • Washington, District of Columbia
    United States

    Site Not Available

  • empty

    Washington, D.C., District of Columbia
    United States

    Site Not Available

  • Boca Raton Regional Hospital

    Boca Raton, Florida 33486
    United States

    Site Not Available

  • Boca Raton, Florida
    United States

    Site Not Available

  • University Cancer Institute (UCI)

    Boynton Beach, Florida 33426
    United States

    Site Not Available

  • Boynton Beach, Florida
    United States

    Site Not Available

  • Michael and Dianne Bienes Cancer Center

    Fort Lauderdale, Florida 33308
    United States

    Site Not Available

  • Fort Lauderdale, Florida
    United States

    Site Not Available

  • Florida Cancer Specialists & Research Center

    Fort Myers, Florida 33916
    United States

    Site Not Available

  • Fort Myers, Florida
    United States

    Site Not Available

  • Memorial Regional Cancer Center

    Hollywood, Florida 33021
    United States

    Site Not Available

  • Hollywood, Florida
    United States

    Site Not Available

  • Baptist Cancer Institute (BCI)

    Jacksonville, Florida 32207
    United States

    Site Not Available

  • Jacksonville, Florida
    United States

    Site Not Available

  • Cancer Care of North Florida

    Lake City, Florida 32024
    United States

    Site Not Available

  • Lake City, Florida
    United States

    Site Not Available

  • Florida Cancer Specialists - Oncology

    Saint Petersburg, Florida 33705
    United States

    Site Not Available

  • Saint Petersburg, Florida
    United States

    Site Not Available

  • Cleveland Clinic Florida - Oncology

    Weston, Florida 33331
    United States

    Site Not Available

  • Weston, Florida
    United States

    Site Not Available

  • Emory University - Winship Cancer Institute

    Atlanta, Georgia 30322
    United States

    Site Not Available

  • Atlanta, Georgia
    United States

    Site Not Available

  • Georgia Regents University

    Augusta, Georgia 30912
    United States

    Site Not Available

  • Augusta, Georgia
    United States

    Site Not Available

  • Central Georgina Cancer Care

    Macon, Georgia 31201
    United States

    Site Not Available

  • Macon, Georgia
    United States

    Site Not Available

  • Northwest Georgia Oncology Centers PC

    Marietta, Georgia 30060
    United States

    Site Not Available

  • Marietta, Georgia
    United States

    Site Not Available

  • Harbin Clinic - Tony E Warren, MD Cancer Center

    Rome, Georgia 30165
    United States

    Site Not Available

  • Moanalua Medical Center

    Honolulu, Hawaii 96819
    United States

    Site Not Available

  • Rush University Medical Center

    Chicago, Illinois 60612
    United States

    Site Not Available

  • Chicago, Illinois
    United States

    Site Not Available

  • Loyola University Medical Center

    Maywood, Illinois 60153
    United States

    Site Not Available

  • Cancer Care & Hematology Specialists

    Niles, Illinois 60714
    United States

    Site Not Available

  • Niles, Illinois
    United States

    Site Not Available

  • Fort Wayne Medical Oncology and Hematology

    Fort Wayne, Indiana 46845
    United States

    Site Not Available

  • Fort Wayne, Indiana
    United States

    Site Not Available

  • University Of Iowa Hospitals-oncology

    Iowa City, Iowa 52242
    United States

    Site Not Available

  • Iowa City, Iowa
    United States

    Site Not Available

  • Norton Cancer Institute

    Louisville, Kentucky 40202
    United States

    Site Not Available

  • Louisville, Kentucky
    United States

    Site Not Available

  • Lafayette General Medical-hematology/oncology

    Lafayette, Louisiana 70503
    United States

    Site Not Available

  • Lafayette, Louisiana
    United States

    Site Not Available

  • Crescent City Research Consortium, LLC

    Marrero, Louisiana 70072
    United States

    Site Not Available

  • Marrero, Louisiana
    United States

    Site Not Available

  • Willis Knighton Cancer Center

    Shreveport, Louisiana 71103
    United States

    Site Not Available

  • Shreveport, Louisiana
    United States

    Site Not Available

  • Anne Arundel Medical Center-oncology

    Annapolis, Maryland 21401
    United States

    Site Not Available

  • Annapolis, Maryland
    United States

    Site Not Available

  • University of Maryland - Oncology

    Baltimore, Maryland 21201
    United States

    Site Not Available

  • Baltimore, Maryland
    United States

    Site Not Available

  • Oncology Care Consultants

    Frederick, Maryland 21701
    United States

    Site Not Available

  • Frederick, Maryland
    United States

    Site Not Available

  • Dana-Farber Cancer Institute - Satellite site

    Boston, Massachusetts 02215
    United States

    Site Not Available

  • Boston, Massachusetts
    United States

    Site Not Available

  • University Of Michigan Hospital - Oncology

    Ann Arbor, Michigan 48109
    United States

    Site Not Available

  • Henry Ford Hospital - Hematology/oncology

    Detroit, Michigan 48202
    United States

    Site Not Available

  • Detroit, Michigan
    United States

    Site Not Available

  • Sparrow Regional Cancer center

    Lansing, Michigan 48912
    United States

    Site Not Available

  • St Lukes Hospital-hematology/oncology

    Duluth, Minnesota 55805
    United States

    Site Not Available

  • Duluth, Minnesota
    United States

    Site Not Available

  • Rochester, Minnesota
    United States

    Site Not Available

  • Ellis Fischel Cancer Center Univers

    Columbia, Missouri 65212
    United States

    Site Not Available

  • Research Medical Center

    Kansas City, Missouri 64132
    United States

    Site Not Available

  • Kansas City, Missouri
    United States

    Site Not Available

  • Saint Louis, Missouri
    United States

    Site Not Available

  • Washington Univ School of Meds - Div of Oncology

    St Louis, Missouri 63110
    United States

    Site Not Available

  • University Of Nebraska Medical Center - Section Of Oncology-hematology

    Omaha, Nebraska 68198
    United States

    Site Not Available

  • Omaha, Nebraska
    United States

    Site Not Available

  • VA Southern Nevada Healthcare

    Las Vegas, Nevada 89135
    United States

    Site Not Available

  • New Hampshire Oncology Hematology, PA

    Hooksett, New Hampshire 03106
    United States

    Site Not Available

  • Hooksett, New Hampshire
    United States

    Site Not Available

  • New Jersey Hematology Oncology Ass.

    Brick, New Jersey 08724
    United States

    Site Not Available

  • Brick, New Jersey
    United States

    Site Not Available

  • empty

    Bricktown, New Jersey
    United States

    Site Not Available

  • Regional Cancer Care Associates

    Cherry Hill, New Jersey 08003
    United States

    Site Not Available

  • John Theurer Cancer Center at Hackensack Medical Center

    Hackensack, New Jersey 07601
    United States

    Site Not Available

  • Hackensack, New Jersey
    United States

    Site Not Available

  • St Barnabas Medical Ctr-hematology/oncology

    Livingston, New Jersey 07039
    United States

    Site Not Available

  • Livingston, New Jersey
    United States

    Site Not Available

  • Hematology Oncology Associates Pa

    Plainfield, New Jersey 07060
    United States

    Site Not Available

  • Plainfield, New Jersey
    United States

    Site Not Available

  • Regional Cancer Care Associates LLC

    Somerville, New Jersey 08876
    United States

    Site Not Available

  • Somerville, New Jersey
    United States

    Site Not Available

  • Overlook Hospital - Carol G Simon

    Summit, New Jersey 07901
    United States

    Site Not Available

  • Summit, New Jersey
    United States

    Site Not Available

  • Winthrop University Medical Center

    Mineola, New York 11501
    United States

    Site Not Available

  • Mineola, New York
    United States

    Site Not Available

  • Icahn School of Medicine at Mount Sinai

    New York, New York 10029
    United States

    Site Not Available

  • New York, New York
    United States

    Site Not Available

  • Icahn School of Medicine at Mount Sinai

    Ny, New York 10029
    United States

    Site Not Available

  • Randolph Hospital-hematology/oncology

    Asheboro, North Carolina 27203
    United States

    Site Not Available

  • Asheboro, North Carolina
    United States

    Site Not Available

  • Levine Cancer Institute

    Charlotte, North Carolina 28204
    United States

    Site Not Available

  • Charlotte, North Carolina
    United States

    Site Not Available

  • FirstHealth of the Carolinas - FirstHealth Outpatient Cancer Center

    Pinehurst, North Carolina 28374
    United States

    Site Not Available

  • Pinehurst, North Carolina
    United States

    Site Not Available

  • Novant Health Forsyth Medical Center

    Winston Salem, North Carolina 27103
    United States

    Site Not Available

  • Winston-Salem, North Carolina
    United States

    Site Not Available

  • Gabrail Cancer Center

    Canton, Ohio 44718
    United States

    Site Not Available

  • Canton, Ohio
    United States

    Site Not Available

  • Metrohealth Medical Center

    Cleveland, Ohio 44109
    United States

    Site Not Available

  • Cleveland, Ohio
    United States

    Site Not Available

  • University Hospital East-ohio State Univ Hospital-hematology/oncology

    Columbus, Ohio 43210
    United States

    Site Not Available

  • Columbus, Ohio
    United States

    Site Not Available

  • Signal Point Hematology Oncology

    Middletown, Ohio 45042
    United States

    Site Not Available

  • Bend Memorial Clinic

    Bend, Oregon 97701
    United States

    Site Not Available

  • Bend, Oregon
    United States

    Site Not Available

  • Lehigh Valley Health network (Oncology)

    Bethlehem, Pennsylvania 18017
    United States

    Site Not Available

  • Bethlehem, Pennsylvania
    United States

    Site Not Available

  • VA Pittsburgh Healthcare System

    Pittsburgh, Pennsylvania 15240
    United States

    Site Not Available

  • Pittsburgh, Pennsylvania
    United States

    Site Not Available

  • Spartanburg, South Carolina
    United States

    Site Not Available

  • Spartanburg Regional Health Services

    Spartenburg, South Carolina 29303
    United States

    Site Not Available

  • Avera Medical Group - Oncology & Hematology

    Sioux Falls, South Dakota 57105
    United States

    Site Not Available

  • Sioux Falls, South Dakota
    United States

    Site Not Available

  • Tennessee Oncology, PLLC

    Chattanooga, Tennessee 37404
    United States

    Site Not Available

  • Chattanooga, Tennessee
    United States

    Site Not Available

  • Sarah Cannon Research Institute - Oncology

    Nashville, Tennessee 37203
    United States

    Site Not Available

  • Nashville, Tennessee
    United States

    Site Not Available

  • Arlington Cancer Center

    Arlington, Texas 76012
    United States

    Site Not Available

  • Arlington, Texas
    United States

    Site Not Available

  • Cancer Center at Doctor's Hospital at Renaissance

    Edinburg, Texas 78539
    United States

    Site Not Available

  • Edinburg, Texas
    United States

    Site Not Available

  • San Antonio Miliary Medical Center

    Fort Sam Houston, Texas 78234
    United States

    Site Not Available

  • Fort Sam Houston, Texas
    United States

    Site Not Available

  • The Center for Cancer and Blood Disorders

    Fort Worth, Texas 76104
    United States

    Site Not Available

  • Fort Worth, Texas
    United States

    Site Not Available

  • Millennium Oncology

    Houston, Texas 77090
    United States

    Site Not Available

  • Houston, Texas
    United States

    Site Not Available

  • Plano, Texas
    United States

    Site Not Available

  • University of Texas Health Science Center

    San Antonio, Texas 78229
    United States

    Site Not Available

  • San Antonio, Texas
    United States

    Site Not Available

  • Texas Health Physicians Group - Oncology

    Texas, Texas 75093
    United States

    Site Not Available

  • Northern Utah Associates

    Ogden, Utah 84403
    United States

    Site Not Available

  • Ogden, Utah
    United States

    Site Not Available

  • Seattle Cancer Alliance

    Seattle, Washington 98109
    United States

    Site Not Available

  • Seattle, Washington
    United States

    Site Not Available

  • Medical Oncology Associates, P.S.

    Spokane, Washington 99208
    United States

    Site Not Available

  • Spokane, Washington
    United States

    Site Not Available

  • Northwest Medical Specialists

    Tacoma, Washington 98405
    United States

    Site Not Available

  • Tacoma, Washington
    United States

    Site Not Available

  • Froedtert Memorial

    Milwaukee, Wisconsin 53226
    United States

    Site Not Available

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